Role of pore dilation in molecular transport through the nuclear pore complex: Insights from polymer scaling theory. [PDF]
PLoS Comput Biol, 2023 Recent studies have suggested that the Nuclear Pore Complex (NPC) plays a significant role in mechanotransduction. When a force is exerted, the NPC's diameter widens, leading to an increased molecular flux into the nucleus. In this study, we sought to further explore this phenomenon and quantitativelly assess the impact of pore dilation on molecular ...
Matsuda A, Mofrad MRK.
europepmc +2 more sources
Nuclear warfare: pathogen manipulation of the nuclear pore complex and nuclear functions [PDF]
mBioViruses and bacteria exploit the nuclear pore complex (NPC) and host nuclear functions to bypass cellular barriers and manipulate essential processes. Viruses frequently engage directly with NPC components, such as nucleoporins, to enable genome import ...
Brianna Steiert, Mary M. Weber
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Uip4p modulates nuclear pore complex function in Saccharomyces cerevisiae [PDF]
Nucleus, 2022 A double membrane bilayer perforated by nuclear pore complexes (NPCs) governs the shape of the nucleus, the prominent distinguishing organelle of a eukaryotic cell.
Pallavi Deolal +2 more
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Caspase-mediated nuclear pore complex trimming in cell differentiation and endoplasmic reticulum stress [PDF]
eLife, 2023 During apoptosis, caspases degrade 8 out of ~30 nucleoporins to irreversibly demolish the nuclear pore complex. However, for poorly understood reasons, caspases are also activated during cell differentiation.
Ukrae H Cho, Martin W Hetzer
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Higher nucleoporin-Importinβ affinity at the nuclear basket increases nucleocytoplasmic import. [PDF]
PLoS ONE, 2013 Several in vitro studies have shown the presence of an affinity gradient in nuclear pore complex proteins for the import receptor Importinβ, at least partially contributing to nucleocytoplasmic transport, while others have historically argued against the
Mohammad Azimi, Mohammad R K Mofrad
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Diffusion of Macromolecules across the Nuclear Pore Complex [PDF]
, 2007 Nuclear pore complexes (NPCs) are very selective filters that monitor the transport between the cytoplasm and the nucleoplasm. Two models have been suggested for the plug of the NPC. They are (i) it is a reversible hydrogel or (ii) it is a polymer brush.
Alber +71 more
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An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae [PDF]
eLife, 2022 The nuclear pore complex (NPC) is the central portal for macromolecular exchange between the nucleus and cytoplasm. In all eukaryotes, NPCs assemble into an intact nuclear envelope (NE) during interphase, but the process of NPC biogenesis remains poorly ...
Annemarie Kralt +12 more
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Redox-Sensitive Cysteines Confer Proximal Control of the Molecular Crowding Barrier in the Nuclear Pore [PDF]
Cell Reports, 2020 Summary: The nuclear pore complex forms a highly crowded selective barrier with intrinsically disordered regions at the nuclear membrane to coordinate nucleocytoplasmic molecular communications.
Wanzhen Zhang +5 more
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RNA export through the nuclear pore complex is directional [PDF]
Nature Communications, 2022 There is little information on export directionality of RNA passing through the nuclear pore complex in human cells. Here, the authors examine single RNA molecules in transit, to demonstrate 5’-first directionality for the export of mRNA and lncRNA.
Asaf Ashkenazy-Titelman +4 more
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Components of coated vesicles and nuclear pore complexes share a common molecular architecture. [PDF]
PLoS Biology, 2004 Numerous features distinguish prokaryotes from eukaryotes, chief among which are the distinctive internal membrane systems of eukaryotic cells. These membrane systems form elaborate compartments and vesicular trafficking pathways, and sequester the ...
Damien Devos +6 more
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