Results 11 to 20 of about 294,484 (344)

In situ architecture of the algal nuclear pore complex

Nature Communications, 2018
While the architecture of vertebrate nuclear pore complexes (NPCs) is well understood, the extent of its evolutionary conservation is still unclear.
Shyamal Mosalaganti, Jan Kosinski, Sahradha Albert, Miroslava Schaffer, Daniela Strenkert, Patrice A. Salomé, Sabeeha S. Merchant, Jürgen M. Plitzko, Wolfgang Baumeister, Benjamin D. Engel, Martin Beck   +10 more
doaj   +2 more sources

Mechanosensing at the Nuclear Envelope by Nuclear Pore Complex Stretch Activation and Its Effect in Physiology and Pathology

Frontiers in Physiology, 2019
Cell fate is correlated to mechanotransduction, in which forces transmitted by the cytoskeleton filaments alter the nuclear shape, affecting transcription factor import/export, cells transcription activity and chromatin distribution.
F. Donnaloja, E. Jacchetti, M. Soncini, M. T. Raimondi   +3 more
doaj   +2 more sources

The Nuclear Pore Complex: A Target for NS3 Protease of Dengue and Zika Viruses

Viruses, 2020
During flavivirus infection, some viral proteins move to the nucleus and cellular components are relocated from the nucleus to the cytoplasm. Thus, the integrity of the main regulator of the nuclear-cytoplasmic transport, the nuclear pore complex (NPC ...
Luis Adrián De Jesús-González, Margot Cervantes-Salazar, José Manuel Reyes-Ruiz, Juan Fidel Osuna-Ramos, Carlos Noe Farfán-Morales, Selvin Noé Palacios-Rápalo, José Humberto Pérez-Olais, Carlos Daniel Cordero-Rivera, Arianna M. Hurtado-Monzón, Fernando Ruíz-Jiménez, Ana Lorena Gutiérrez-Escolano, Rosa María del Ángel   +11 more
doaj   +2 more sources

Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer's disease. [PDF]

Elife
Bansal VA, Tan JM, Soon HR, Zainolabidin N, Saido T, Ch'ng TH.   +5 more
europepmc   +2 more sources

The nuclear pore complex [PDF]

The Journal of cell biology, 1993
Over the past years, significant progress has been made both in the analysis of the structural and molecular organization of the nuclear pore complex (NPC) and the mechanism of nuclear transport. In this minireview, I will focus on some of the recent developments in this field.
N, Panté, U, Aebi
openaire   +5 more sources

A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis

Open Biology, 2021
The integral membrane protein Apq12 is an important nuclear envelope (NE)/endoplasmic reticulum (ER) modulator that cooperates with the nuclear pore complex (NPC) biogenesis factors Brl1 and Brr6. How Apq12 executes these functions is unknown.
Wanlu Zhang, Azqa Khan, Jlenia Vitale, Annett Neuner, Kerstin Rink, Christian Lüchtenborg, Britta Brügger, Thomas H. Söllner, Elmar Schiebel   +8 more
doaj   +1 more source

The cellular environment shapes the nuclear pore complex architecture

Nature, 2021
Nuclear pore complexes (NPCs) create large conduits for cargo transport between the nucleus and cytoplasm across the nuclear envelope (NE)1–3. These multi-megadalton structures are composed of about thirty different nucleoporins that are distributed in ...
A. Schuller, M. Wojtynek, D. Mankus, M. Tatli, R. Kronenberg-Tenga, S. Regmi, P. Dip, Abigail K. R. Lytton-Jean, E. Brignole, M. Dasso, K. Weis, O. Medalia, T. Schwartz   +12 more
semanticscholar   +1 more source

Comprehensive structure and functional adaptations of the yeast nuclear pore complex

Cell, 2021
Nuclear Pore Complexes (NPCs) mediate the nucleocytoplasmic transport of macromolecules. Here we provide a structure of the yeast NPC in which the inner ring is resolved by cryo-EM at - helical resolution to show how flexible connectors tie together ...
C. Akey, Digvijay Singh, Christna Ouch, Ignacia Echeverria, I. Nudelman, Joseph M. Varberg, Zulin Yu, Fei Fang, Yi Shi, Junjie Wang, Daniel Salzberg, Kangkang Song, Chen Xu, J. Gumbart, S. Suslov, J. Unruh, Sue L. Jaspersen, B. Chait, A. Sali, Javier Fernandez-Martinez, S. Ludtke, E. Villa, M. Rout   +22 more
semanticscholar   +1 more source

Nuclear pore complex and stem cell homeostasis

生物医学转化, 2021
As a channel for mediating exchange between the nucleus and cytoplasm, the nuclear pore complex (NPC) is a macromolecular complex composed of about 30 nucleoporins.
Li Lanzhu, Ji Zhejun, Zhang Weiqi, Qu Jing, Liu Guanghui   +4 more
doaj   +1 more source

Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS

Science Translational Medicine, 2021
Nuclear accumulation of CHMP7 leads to multiple cellular pathologies that can be mitigated via CHMP7 ASOs in familial and sporadic ALS iPSNs. Repairing the nuclear pore in ALS The majority of amyotrophic lateral sclerosis (ALS) cases are of unknown ...
Alyssa N. Coyne, Victoria Baskerville, Benjamin L. Zaepfel, D. Dickson, F. Rigo, F. Bennett, C. Lusk, J. Rothstein   +7 more
semanticscholar   +1 more source