Results 31 to 40 of about 294,484 (344)
Nuclear Envelope: Nuclear Pore Complexity [PDF]
Current Biology, 2005 A new study shows that the filamentous fungus, Aspergillus nidulans, which has a closed mitosis, does not maintain a continuous permeability barrier during mitosis. This work challenges current views of the differences between closed and open mitosis and has implications for understanding mitotic specific changes in the nuclear pore complex and Ran ...
openaire +2 more sources
Structure of the Cytoplasmic Ring of the Xenopus laevis Nuclear Pore Complex
bioRxiv, 2020 Nuclear pore complex (NPC) exhibits structural plasticity and has only been characterized at local resolutions of up to 15 Å for the cytoplasmic ring (CR).
Gaoxingyu Huang +10 more
semanticscholar +1 more source
The Structure of the Nuclear Pore Complex (An Update).
Annual Review of Biochemistry, 2019 The nuclear pore complex (NPC) serves as the sole bidirectional gateway of macromolecules in and out of the nucleus. Owing to its size and complexity (∼1,000 protein subunits, ∼110 MDa in humans), the NPC has remained one of the foremost challenges for ...
D. H. Lin, A. Hoelz
semanticscholar +1 more source
Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex
Cell Research, 2020 The nuclear pore complex (NPC) mediates the flow of substances between the nucleus and cytoplasm in eukaryotic cells. Here we report the cryo-electron tomography (cryo-ET) structure of the luminal ring (LR) of the NPC from Xenopus laevis oocyte.
Yanqing Zhang +14 more
semanticscholar +1 more source
Viral Subversion of the Nuclear Pore Complex
Viruses, 2013 The nuclear pore complex (NPC) acts as a selective barrier between the nucleus and the cytoplasm and is responsible for mediating communication by regulating the transport of RNA and proteins. Numerous viral pathogens have evolved different mechanisms to
Valerie Le Sage, Andrew J. Mouland
doaj +1 more source
Dissecting the Structural Dynamics of the Nuclear Pore Complex.
Molecules and Cells, 2020 Cellular processes are largely carried out by macromolecular assemblies, most of which are dynamic, having components that are in constant flux. One such assembly is the nuclear pore complex (NPC), an ∼50 MDa assembly comprised of ∼30 different proteins ...
Zhanna Hakhverdyan +11 more
semanticscholar +1 more source
Cell Reports, 2020 Summary: The nuclear pore complex forms a highly crowded selective barrier with intrinsically disordered regions at the nuclear membrane to coordinate nucleocytoplasmic molecular communications.
Wanzhen Zhang +5 more
doaj +1 more source
Nup133 Is Required for Proper Nuclear Pore Basket Assembly and Dynamics in Embryonic Stem Cells
Cell Reports, 2018 Summary: Nup133 belongs to the Y-complex, a key component of the nuclear pore complex (NPC) scaffold. Studies on a null mutation in mice previously revealed that Nup133 is essential for embryonic development but not for mouse embryonic stem cell (mESC ...
Benoit Souquet +7 more
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Structure and Assembly of the Nuclear Pore Complex.
Annual Review of Biophysics, 2019 Nuclear pore complexes (NPCs) mediate nucleocytoplasmic exchange. They are exceptionally large protein complexes that fuse the inner and outer nuclear membranes to form channels across the nuclear envelope.
Bernhard Hampoelz +3 more
semanticscholar +1 more source
The Nuclear Pore Complex and mRNA Export in Cancer
Cancers, 2020 Simple Summary There are multiple processes that can go awry to drive cancer. One of these arises from a dysregulation of trafficking of cellular materials between the two major compartments of the cell—the nucleus and the cytoplasm.
K. Borden
semanticscholar +1 more source