Results 41 to 50 of about 881,535 (329)
Nuclear receptors: a bridge linking the gut microbiome and the host
Molecular Medicine, 2021 Background The gut microbiome is the totality of microorganisms, bacteria, viruses, protozoa, and fungi within the gastrointestinal tract. The gut microbiome plays key roles in various physiological and pathological processes through regulating varieties
Zixuan Wang +2 more
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Glucocorticoids for human skin: New aspects of the mechanism of action [PDF]
, 2005 Topical glucocorticoids have always been considered first-line drugs for inflammatory diseases of the skin and bronchial system. Applied systemically, glucocorticoids are used for severe inflammatory and immunological diseases and the inhibition of ...
Ahmed, M. +4 more
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Nuclear receptors of NR1 and NR4 subfamilies in the regulation of microglial functions and pathology
Pharmacology Research & Perspectives, 2021 This review provides an overview of researches on the NR1 and NR4 nuclear receptors involved in the regulation of microglial functions. Nuclear receptors are attractive candidates for drug targets in the therapies of the central nervous system disorders,
Hiroshi Katsuki
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Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation [PDF]
, 2017 RXRA regulates transcription as part of a heterodimer with 14 other nuclear receptors, including the peroxisome proliferator-activated receptors (PPARs).
Arora, Vivek K +7 more
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Effect of antiandrogen flutamide on measures of hepatic regeneration in rats [PDF]
, 1989 Male rat liver undergoes a process of demasculinization during hepatic regeneration following partial hepatectomy. The possibility that antiandrogens might potentiate this demasculinization process and in so doing augment the hepatic regenerative ...
A Francavilla +36 more
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Nuclear Hormone Receptors and Their Ligands: Metabolites in Control of Transcription
Cells, 2020 Nuclear hormone receptors are a family of transcription factors regulated by small molecules derived from the endogenous metabolism or diet. There are forty-eight nuclear hormone receptors in the human genome, twenty of which are still orphans.
Lian Jing Tao +4 more
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Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]
, 2010 Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
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The NAE Pathway : autobahn to the nucleus for cell surface receptors [PDF]
, 2019 Various growth factors and full-length cell surface receptors such as EGFR are translocated from the cell surface to the nucleoplasm, baffling cell biologists to the mechanisms and functions of this process. Elevated levels of nuclear EGFR correlate with
Bard, Frederic A. +3 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez +13 more
wiley +1 more source
CellsAndrogen receptor (AR) transcriptional activity significantly influences prostate cancer (PCa) progression. In addition to ligand stimulation, AR transcriptional activity is also influenced by a variety of post-translational modifications (PTMs).
Lance Edward V. Lumahan +3 more
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