Results 91 to 100 of about 14,540 (195)

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, EarlyView.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source

A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control.

PLoS Genetics, 2017
How cells control the overall size and growth of membrane-bound organelles is an important unanswered question of cell biology. Fission yeast cells maintain a nuclear size proportional to cellular size, resulting in a constant ratio between nuclear and ...
Kazunori Kume, Helena Cantwell, Frank R Neumann, Andrew W Jones, Ambrosius P Snijders, Paul Nurse   +5 more
doaj   +1 more source

Comprehensive Quantification of Oligoasthenozoospermia Induced by Obesity, Reproductive Toxicants, and Their Combination in Rat Models

Andrology, Volume 14, Issue 6, Page 1535-1551, September 2026.
ABSTRACT Background Oligoasthenozoospermia is a leading cause of male infertility and has been increasingly associated with the global surge in obesity and exposure to reproductive toxicants. Despite extensive research on each factor individually, their combined pathological effects remain poorly understood.
Yunlong Yao, Xi Zhang, Lingru Li, Yunzhi Zhang, Shuo Huang, Yulin Zong, Mingrui Li, Fufangyu Zhao, Linghui Zhu, Tianxing Li, Wenlong Sun, Mingyan Shao, Yanfei Zheng   +12 more
wiley   +1 more source

Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology

Neurobiology of Disease
Alterations in transactivating response region DNA-binding protein 43 (TDP-43) are prevalent in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurological disorders.
Constance Zhou, Evelyn J. Hardin, Till S. Zimmer, Stephanie Jackvony, Daniel Barnett, Noopur Khobrekar, Elisa Giacomelli, Lorenz Studer, Adam L. Orr, Anna G. Orr   +9 more
doaj   +1 more source

Dnajb5 From Antarctic Fish Reveals a Redox‐Sensitive Mechanism Coordinating Muscle Regeneration via mTORC1 and HDAC4

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Dnajb5, a member of the heat shock protein family, has not been previously reported to play a role in muscle differentiation. We identify Dnajb5 as a negative regulator of myogenesis via mammalian target of rapamycin (mTOR) and histone deacetylase 4 (HDAC4) signalling, functioning as a central controller of muscle growth and ...
Sun‐Hee Cho, Min‐Kyung Choi, Mi‐Ock Baek, Hyeon‐Hee Son, Binh Thanh Nguyen, Min‐Jung Kang, Il‐Chan Kim, Jin‐Hyoung Kim, Mee‐Sup Yoon   +8 more
wiley   +1 more source

Structural Basis of Targeting the Exportin CRM1 in Cancer

Cells, 2015
Recent studies have demonstrated the interference of nucleocytoplasmic trafficking with the establishment and maintenance of various cancers. Nucleocytoplasmic transport is highly regulated and coordinated, involving different nuclear transport factors ...
Achim Dickmanns, Thomas Monecke, Ralf Ficner   +2 more
doaj   +1 more source

Proteomic and Phosphoproteomic Characteristics of Multiple Brain Regions in Rhesus Macaques After SARS‐CoV‐2 Infection

MedComm, Volume 7, Issue 8, August 2026.
The study found that SARS‐CoV‐2 Omicron infection causes region‐specific inflammatory, immune, synaptic, and signaling disorders in the brain, and the predicted kinases and differentially expressed proteins may serve as potential targets for COVID‐19‐related drug discovery.
Qiaochu Wang, Yanan Zhou, Tao Ding, Yan Sun, Yehong Yang, Yue Wu, Jiangfeng Liu, Shuaiyao Lu, Juntao Yang   +8 more
wiley   +1 more source

Omics Insights Into the Effects of Highbush Blueberry and Cranberry Crop Agroecosystems on Honey Bee Health and Physiology

PROTEOMICS, Volume 26, Issue 8, Page 41-57, August 2026.
ABSTRACT Honey bees (Apis mellifera) are vital pollinators in fruit‐producing agroecosystems like highbush blueberry (HBB) and cranberry (CRA). However, their health is threatened by multiple interacting stressors, including pesticides, pathogens, and nutritional changes.
Huan Zhong, Yuming Shi, Aleksandra Kozlova, Renata Moravcova, Jason C. Rogalski, Aidan Jamieson, Lance Lansing, Kyung‐Mee Moon, Xiaojing Yuan, Amanda S. Gregoris, Heather Higo, Julia Common, Ida M. Conflitti, Mateus Pepinelli, Lan Tran, Morgan Cunningham, Hosna Jabbari, Syed Abbas Bukhari, Sarah K. French, Rodrigo Ortega Polo, Shelley E. Hoover, Stephen F. Pernal, Pierre Giovenazzo, M. Marta Guarna, Amro Zayed, Leonard J. Foster   +25 more
wiley   +1 more source

Mislocalization of nucleic acids is a convergent and targetable mechanism in Alzheimer's disease and frontotemporal dementia

Cell Reports
Summary: Nucleocytoplasmic transport defects are observed in Alzheimer's disease (AD) and frontotemporal dementia (FTD). Here, we assess mRNA nucleocytoplasmic localization by performing transcriptome-wide profiling on nuclear and cytoplasmic fractions ...
Christy Hung, Miriam Llorian, Koustav Pal, Frederick J. Livesey, Jyoti Choudhary, Theodoros I. Roumeliotis, Rickie Patani   +6 more
doaj   +1 more source

Nuclear Envelope Permeability Barrier as a Fast‐Response Intracellular Mechanostat

Advanced Science, 2019
The nuclear envelope is an undisputed component of the intracellular mechanotransduction cascades which collect, process, and respond to mechanical stimuli from the environment.
Victor Shahin, Ivan U. Kouzel, Gonzalo Rosso, Ivan Liashkovich   +3 more
doaj   +1 more source