Results 101 to 110 of about 14,540 (195)

Proteomic Changes in Cancer Cell Lines as a Result of Bacterial Infection

PROTEOMICS, Volume 26, Issue 8, Page 58-68, August 2026.
ABSTRACT Bacterial infections have been implicated in shaping the tumor microenvironment (TME), but their effects on cancer cell proteomes remain unexplored. In this study, we analyzed proteomic changes in melanoma (A375) and ovarian cancer (OVCAR3) cell line models following infection with Staphylococcus aureus strain USA300 or Salmonella enterica ...
Bo Ren, Kenneth Weke, Darryl Hardie, Mariya I. Goncheva, Ted Hupp, Javier Antonio Alfaro, Helena Pětrošová, David R. Goodlett   +7 more
wiley   +1 more source

Non‐Contact Transspatial Regulatory Function of the Extracellular Matrix

Smart Medicine, Volume 5, Issue 4, August 2026.
Non‐contact transspatial regulation of the extracellular matrix (ECM), whereby the ECM remotely modulates cellular behavior without direct physical contact, is proposed and systematically investigated for the first time. This process involves multiple pathways and components, with actin‐dependent macropinocytosis playing a predominant role potentially.
Ting Cao, Chen Yang, Zhengyang Wang, Changmin Shao, Ziye Xu, Baode Chen, Jiayu Zhang, Yongcheng Wang, Fangfu Ye   +8 more
wiley   +1 more source

The ELAVL1‐PLAUR‐suPAR Axis Exacerbates Diabetic Nephropathy by Promoting Podocyte Injury and Inflammation

Journal of Diabetes, Volume 18, Issue 8, August 2026.
This study identifies a novel pathogenic pathway in DN wherein hyperglycemia‐induced ELAVL1 upregulates PLAUR expression and promotes suPAR release from podocytes, leading to renal inflammation and injury. ABSTRACT Background Diabetic nephropathy (DN) is a leading cause of end‐stage renal disease.
DanDan Xu, Liang Xu, LinLin Li
wiley   +1 more source

Strategies for the Viral Exploitation of Nuclear Pore Transport Pathways

Viruses
Viruses frequently exploit the host’s nucleocytoplasmic trafficking machinery to facilitate their replication and evade immune defenses. By encoding specialized proteins and other components, they strategically target host nuclear transport receptors ...
Xin Zhang, Keesiang Lim, Yujia Qiu, Masaharu Hazawa, Richard W. Wong   +4 more
doaj   +1 more source

Endothelial AGGF1 Deficiency Causes Mitochondrial Dysfunction and Contributes to Age‐Elevated Blood Pressure

Aging Cell, Volume 25, Issue 8, August 2026.
Endothelial AGGF1 deficiency contributes to early vascular aging and age‐elevated blood pressure via inhibiting the SESN2/p‐eNOS pathway. Age‐dependent AGGF1 attenuation reduces its binding to the SESN2 promoter. SESN2 downregulation induces mitochondrial respiratory dysfunction and elevated mitochondrial ROS, thereby reducing eNOS phosphorylation ...
Weixin Lv, Xiaojuan Zhong, Qiang Yuan, Xueting Gong, Ya Zhao, Shilin Zhang, Andong Wu, Ming Wan, Xueer Li, Yangyi Zheng, Jiankun Liu, Bingbing Zhou, Yuanzheng Zhu, Limin Zhao, Qiquan Wang, Yang Xiang, Xiao‐Li Tian   +16 more
wiley   +1 more source

Jiuwei Xiaozhi Decoction Alleviates High‐Fat Diet‐Induced MASLD by Suppressing Hepatic SREBP2‐Driven Cholesterogenesis and Restoring PPARα‐Mediated Fatty Acid Oxidation

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Studies have found that Jiuwei Xiaozhi Decoction can improve high‐fat diet‐induced fatty liver disease, mainly by regulating the SREBP2 and PPARα pathways to balance hepatic lipid metabolism while reducing inflammatory responses. ABSTRACT Jiuwei Xiaozhi Decoction (JWXZ) is a nine‐herb traditional Chinese medicine formula clinically used for hepatic ...
Youcheng Ma, Xinrui Gao, Ji Wang, Lingru Li, Zhen Huang, Fangli Li   +5 more
wiley   +1 more source

Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism

Cell Proliferation, Volume 59, Issue 8, August 2026.
Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang, Yuan‐Tao Qiu, Jing‐Yue Cao, Yi‐Feng Huang, Ye‐Lin Lan, Yu‐Li Zhao, Fu Wu, Chen‐Long Wang, Guo‐Run Tang, Jing‐Yun Ji, Zhang Zhang, Guan‐Zheng Luo   +11 more
wiley   +1 more source

14‐3‐3 proteins: Central hubs in plant development and stress adaptation

Journal of Integrative Plant Biology, Volume 68, Issue 8, Page 3107-3132, August 2026.
This review highlights recent advances elucidating the important roles of 14‐3‐3 proteins in regulating phytohormone networks, biotic and abiotic stress tolerance, growth‐defense trade‐offs, and evolutionary adaptations. Furthermore, it provides a forward‐looking perspective on 14‐3‐3 biology and the development of climate‐resilient smart crops under ...
Jiale Yuan, Qizhang Wang, Jing Cao, Furong Wang, Hua Zhou, Jigang Li, Fang Lin   +6 more
wiley   +1 more source

The GSK3/SHAGGY‐like OsGSK3 phosphorylates and inhibits phase separation of OsFCA at Ser‐43 and Ser‐45 to regulate brassinosteroid signaling and rice architecture

New Phytologist, Volume 251, Issue 4, Page 1909-1929, August 2026.
A working model for GLYCOGEN SYNTHASE KINASE 3‐mediated phosphorylation of FLOWERING CONTROL LOCUS A in the regulation of brassinosteroid signaling and rice growth and development. Summary Brassinosteroid (BR) signaling plays a critical role in rice (Oryza sativa L.) grain development.
Jiaqi Zhang, Fan Wang, Sijia Zhang, Qian Yu, Qimiao Dong, Jianbo Li, Xianglei Wei, Huaying Du, Ye Shen, Rong Mu, Yanxiao Jia, Jinping Cheng, Hongsheng Zhang, Ji Huang, Xiuying Gao   +14 more
wiley   +1 more source

Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant‐Pathogen Interface

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4799-4822, August 2026.
ABSTRACT The endoplasmic reticulum (ER) stress response, a conserved proteostasis network, has emerged as a central hub that reprograms plant immunity during pathogen attack. This review synthesises how plants harness ER‐stress signalling to mount multilayered defences and how pathogens have evolved counterstrategies to subvert these pathways.
Zhe Meng, Shuqin Zheng, Federica Brandizzi, Yiran Liu, Chunlei Li, Congcong Ai, Yujiao Wang, Jiadong Qi, Xiuguo Zhang   +8 more
wiley   +1 more source