Results 101 to 110 of about 27,476 (204)

Karyopherins regulate nuclear pore complex barrier and transport function [PDF]

, 2017
Nucleocytoplasmic transport is sustained by karyopherins (Kaps) and a Ran guanosine triphosphate (RanGTP) gradient that imports nuclear localization signal (NLS)–specific cargoes (NLS-cargoes) into the nucleus.
Adam, Allen, Bayliss, Bednenko, Ben-Efraim, Binlu Huang, Bischoff, Catimel, Chaillan-Huntington, Chantal Rencurel, Chook, Christie, Cingolani, Cingolani, Conti, Delphin, Eibauer, Eisele, Falces, Floer, Forwood, Forwood, Frey, Fukuhara, Grünwald, Görlich, Görlich, Görlich, Görlich, Hahn, Halder, Hough, Isgro, Kapinos, Kau, Kimura, Kopito, Kubitscheck, Kutay, Kutay, Larisa E. Kapinos, Lee, Lee, Lim, Lim, Lolodi, Lonhienne, Lowe, Lyman, Makise, Milles, Moroianu, Moroianu, Nigg, Ogawa, Paradise, Popken, Pumroy, Pyhtila, Rexach, Ribbeck, Riddick, Roderick Y.H. Lim, Rout, Sakiyama, Schoch, Stewart, Strawn, Sun, Tauchert, Timney, Tokunaga, Tu, von Appen, Vovk, Wagner, Weis, Yamada, Yang, Yang, Yoshimura, Zachariae   +81 more
core   +1 more source

Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling

Cell Proliferation, EarlyView.
We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo, Xiaona Yin, Hongxin He, Yaning Wang, Hongbo Zhang   +4 more
wiley   +1 more source

The effect of cell morphology on the permeability of the nuclear envelope to diffusive factors [PDF]

, 2018
A recent advance in understanding stem cell differentiation is that the cell is able to translate its morphology, i.e., roundish or spread, into a fate decision.
García González, Alberto, Jacchetti, Emanuela, Marotta, Roberto   +2 more
core   +2 more sources

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Ceramide regulation of nuclear protein imports⃞

Journal of Lipid Research, 2008
Nucleocytoplasmic trafficking is an essential and responsive cellular mechanism that directly affects cell growth and proliferation, and its potential to address metabolic challenge is incompletely defined.
Randolph S. Faustino, Paul Cheung, Melanie N. Richard, Elena Dibrov, Annette L. Kneesch, Justin F. Deniset, Mirna N. Chahine, Kaitlin Lee, David Blackwood, Grant N. Pierce   +9 more
doaj   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity

Nature Communications, 2018
The endosomal sorting complex required for transport-III (ESCRT-III) has been implicated in the packaging of HIV and HSV-1 viruses in the cytoplasm. Here the authors show that ESCRT-III proteins are required for the transport of HSV-1 nucleocapsids from ...
Jun Arii, Mizuki Watanabe, Fumio Maeda, Noriko Tokai-Nishizumi, Takahiro Chihara, Masayuki Miura, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi   +9 more
doaj   +1 more source

Nucleocytoplasmic transport [PDF]

Biochemical Journal, 1994
P S, Agutter, D, Prochnow
openaire   +2 more sources

Diversity in Nucleocytoplasmic Transport Pathways.

Cell Structure and Function, 2000
Significant progress has been made toward our understanding of the basic principle of nucleocytoplasmic transport, and the structure of transport factors, as well as the diversity of nucleocytoplasmic transport pathways. This review outlines the current knowledge of transport, and discusses the problems that remain as to how eukaryotic cells acquire ...
openaire   +3 more sources

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, EarlyView.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source