Results 101 to 110 of about 2,127,287 (180)

A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control.

PLoS Genetics, 2017
How cells control the overall size and growth of membrane-bound organelles is an important unanswered question of cell biology. Fission yeast cells maintain a nuclear size proportional to cellular size, resulting in a constant ratio between nuclear and ...
Kazunori Kume, Helena Cantwell, Frank R Neumann, Andrew W Jones, Ambrosius P Snijders, Paul Nurse   +5 more
doaj   +1 more source

Photoperiodism‐Specific QTLs Support Switch‐Like Genetic Control of Obligate Long‐Day Photoperiodism in Mimulus guttatus

Plant Species Biology, Volume 41, Issue 6, November 2026.
Photoperiodic flowering is well studied in facultative photoperiodism plants, but the genetic basis of obligate photoperiodism remains poorly understood. Using QTL mapping and RNA‐seq in Mimulus guttatus, we identified photoperiodism‐specific QTLs that are distinct from flowering‐time QTLs, supporting switch‐like genetic control of obligate long‐day ...
Po‐Kai Huang, Daniel E. Runcie
wiley   +1 more source

Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology

Neurobiology of Disease
Alterations in transactivating response region DNA-binding protein 43 (TDP-43) are prevalent in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurological disorders.
Constance Zhou, Evelyn J. Hardin, Till S. Zimmer, Stephanie Jackvony, Daniel Barnett, Noopur Khobrekar, Elisa Giacomelli, Lorenz Studer, Adam L. Orr, Anna G. Orr   +9 more
doaj   +1 more source

Structural Basis of Targeting the Exportin CRM1 in Cancer

Cells, 2015
Recent studies have demonstrated the interference of nucleocytoplasmic trafficking with the establishment and maintenance of various cancers. Nucleocytoplasmic transport is highly regulated and coordinated, involving different nuclear transport factors ...
Achim Dickmanns, Thomas Monecke, Ralf Ficner   +2 more
doaj   +1 more source

Capturing Hu Antigen R Domain Closure Through Supervised Molecular Dynamics Simulations

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
HuR is a therapeutically relevant RNA‐binding protein that switches from an open apo form to a closed RNA‐bound one. Its atomistic detail is unknown. Here, Supervised Molecular Dynamics is applied for the first time to an intramolecular event: a multistep supervision of interdomain distances reproduces a plausible closure pathway and reveals transient ...
Chiara Cavastracci Strascia, Andrea Dodaro, Gianluca Novello, Silvia Menin, Mattia Sturlese, Veronica Salmaso, Stefano Moro   +6 more
wiley   +1 more source

Modern tools to study nuclear pore complexes and nucleocytoplasmic transport in Caenorhabditis elegans. [PDF]

, 2014
The nematode Caenorhabditis elegans is characterized by many features that make it highly attractive to study nuclear pore complexes (NPCs) and nucleocytoplasmic transport.
Peter Askjaer, Peter Meister, Askjaer, Peter, Meister, Peter, Galy, Vincent, Vincent Galy   +5 more
core   +1 more source

Nucleocytoplasmic transport in human astrocytes: decreased nuclear uptake of the HIV Rev shuttle protein [PDF]

, 2001
Astrocytes are cellular targets for the human immunodeficiency virus (HIV) that limit virus production, owing, at least in part, to the diminished functionality of the viral post-transcriptional stimulatory factor Rev.
Schlicht, S, Neumann, M., Ceccherini-Silberstein, F., Afonina, E., Brack-Werner, R., Neumann, M, Erfle, V, Brack-Werner, R, Pavlakis, G.N., Brack Werner, R., Afonina, E, Schlicht, S., Erfle, V., Pavlakis, G, CECCHERINI SILBERSTEIN, FRANCESCA, Ceccherini-Silberstein, F   +15 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, Volume 20, Issue 10, Page 2466-2489, October 2026.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Ciliary Ift20 and Wwtr1 Coordinate Transforming Growth Factor‐β Receptor II Signaling to Maintain Bone–Fat Balance in Skeletal Homeostasis

MedComm, Volume 7, Issue 10, October 2026.
Deletion of Ift20 and Wwtr1 in osteoprecursors promoted adipogenic differentiation while suppressing osteogenesis and bone remodeling through dysregulation of TGF‐β signaling. Mechanistically, Ift20 stabilized TβRII by inhibiting c‐Cbl‐mediated ubiquitination and proteasomal degradation. In parallel, Wwtr1 functioned as a transcriptional regulator that
Yang Li, Yang Yang, Shuting Yang, Huijuan Chang, Yi‐Ping Li, Shuying Yang   +5 more
wiley   +1 more source

Mislocalization of nucleic acids is a convergent and targetable mechanism in Alzheimer's disease and frontotemporal dementia

Cell Reports
Summary: Nucleocytoplasmic transport defects are observed in Alzheimer's disease (AD) and frontotemporal dementia (FTD). Here, we assess mRNA nucleocytoplasmic localization by performing transcriptome-wide profiling on nuclear and cytoplasmic fractions ...
Christy Hung, Miriam Llorian, Koustav Pal, Frederick J. Livesey, Jyoti Choudhary, Theodoros I. Roumeliotis, Rickie Patani   +6 more
doaj   +1 more source