Results 111 to 120 of about 15,740 (146)

SUMO and Nucleocytoplasmic Transport

2009
The transport of proteins between the nucleus and cytoplasm occurs through nuclear pore complexes and is facilitated by numerous transport factors. These transport processes are often regulated by post-translational modification or, reciprocally, transport can function to control post-translational modifications through regulated transport of key ...
Christopher, Ptak, Richard W, Wozniak
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Nucleocytoplasmic mRNA Transport

2001
How do messenger RNA molecules (mRNAs) migrate from the nucleus to the cytoplasm? Messenger RNA precursors (pre-mRNAs) are synthesized in the nucleus by RNA polymerase II and are then subjected to a series of processing reactions which include the addition of a 7-methylguanosine cap at the 5’ end, the removal of introns by splicing, and the generation ...
Y, Huang, G G, Carmichael
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Control of nucleocytoplasmic transport

Current Opinion in Cell Biology, 1992
The movement of macromolecules between the nucleus and cytoplasm is tightly controlled. In the past few years it has become increasingly apparent that nuclear traffic is regulated not only by recognition of specific signals on proteins and RNAs, but also by cellular factors that modulate the efficacy with which these signals are recognized.
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RNA nucleocytoplasmic transport

Seminars in Cell Biology, 1992
The transport of RNAs from the nucleus to the cytoplasm is an obligatory step in gene expression and may also be a target for regulation. The cellular machinery has the capacity to export a myriad of RNA transcripts, which differ significantly in sequence and structure. Recent work is providing the first glimpses into how RNA export occurs.
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Nucleocytoplasmic RNA Transport

1984
During the past decade, it has become evident that, in eukaryotes, RNA molecules undergo a complex series of chemical modifications after transcription and before translation and that some of these modifications coincide with alterations in subcellular distribution.
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Karyopherin flexibility in nucleocytoplasmic transport

Current Opinion in Structural Biology, 2006
Recent structural work on nuclear transport factors of the importin-beta superfamily of karyopherins has shown that these proteins are superhelices of HEAT repeats that are able to assume different conformations in different functional states. The inherent flexibility of these helicoids facilitates the accommodation of different binding partners by an ...
Elena, Conti, Christoph W, Müller, Murray, Stewart   +2 more
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Nucleocytoplasmic Transport

Annual Review of Biochemistry
Compartmentalization of the genome within the nucleus of eukaryotic cells emerged alongside a two-component molecular machinery for selective transport of macromolecules: a static yet conformationally flexible channel formed by the ∼120-MDa nuclear pore complex (NPC), which generates a size-selective diffusion barrier, and a mobile machinery of ...
George W. Mobbs, Stefan Petrovic, André Hoelz   +2 more
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Nucleocytoplasmic transport

Neurology, 2019
There is a bidirectional communication between the nucleus and the cytoplasm through highly regulated nucleocytoplasmic transport. This process allows the transport of proteins, RNAs, and ribonucleoproteins across the nuclear envelope via the nuclear pore complexes.
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Intracellular Structure and Nucleocytoplasmic Transport

1996
Intracellular movement of any solute or particle accords with one of two general schemes: either it takes place predominantly in the solution phase or it occurs by dynamic interactions with solid-state structures. If nucleocytoplasmic exchanges of macromolecules and complexes are predominantly solution-phase processes, i.e., if the former ...
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Ran in Nucleocytoplasmic Transport

2014
The Ran GTPase is a crucial component of all nucleocytoplasmic transport pathways except those that mediate the nuclear export of mRNAs and ribosome subunits. The nucleotide state of Ran provides a means by which the cytoplasmic and nucleoplasmic compartments are recognized as a consequence of RCC1, the Ran guanine nucleotide exchange factor (RanGEF ...
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