Results 111 to 120 of about 14,540 (195)

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, Volume 49, Issue 8, Page 5849-5865, August 2026.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source

Targeting the nuclear export receptor exportin‐1 in acute myeloid leukaemia: From biology to clinical translation

Clinical and Translational Medicine
Background Exportin‐1 (XPO1), a key regulator of nucleocytoplasmic transport, is frequently dysregulated in acute myeloid leukemia (AML) and contributes to leukemogenesis, disease progression and therapeutic resistance.
Yifan Liu, Xiaoya Yun, Weidong Ding, Suxiao Li, Hui Liu   +4 more
doaj   +1 more source

Adherens junction protein expression is associated with poor response to neoadjuvant FLOT chemotherapy and pro‐inflammatory tumor microenvironment in esophageal adenocarcinoma

International Journal of Cancer, Volume 159, Issue 2, Page 501-515, 15 July 2026.
What's new? Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor survival and variable response to perioperative chemotherapy. Although histopathological features correlate with outcomes, the relationship specifically between adherens junction (AJ) protein expression and treatment response in EAC remains uncertain.
Bastian Grothey, Heike Löser, Tillmann Bedau, Wolfgang Schröder, Christiane J. Bruns, Thomas Zander, Max Krämer, Reinhard Büttner, Alexander Quaas   +8 more
wiley   +1 more source

Nuclear pore complex and nucleocytoplasmic transport disruption in neurodegeneration. [PDF]

FEBS Lett, 2023
Cristi AC, Rapuri S, Coyne AN.
europepmc   +1 more source

Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer’s disease

eLife
The emergence of Aβ pathology is one of the hallmarks of Alzheimer’s disease (AD), but the mechanisms and impact of Aβ in progression of the disease is unclear.
Vibhavari Aysha Bansal, Jia Min Tan, Hui Rong Soon, Norliyana Zainolabidin, Takaomi Saido, Toh Hean Ch'ng   +5 more
doaj   +1 more source

Exportin-mediated nucleocytoplasmic transport maintains Pch2 homeostasis during meiosis. [PDF]

PLoS Genet, 2023
Herruzo E, Sánchez-Díaz E, González-Arranz S, Santos B, Carballo JA, San-Segundo PA.   +5 more
europepmc   +1 more source

Evolutionary, structural and functional insights in nuclear organisation and nucleocytoplasmic transport in trypanosomes. [PDF]

FEBS Lett, 2023
Padilla-Mejia NE, Field MC.
europepmc   +1 more source

Experience-dependent Tip60 nucleocytoplasmic transport is regulated by its NLS/NES sequences for neuroplasticity gene control. [PDF]

Mol Cell Neurosci, 2023
Armour EM, Thomas CM, Greco G, Bhatnagar A, Elefant F.   +4 more
europepmc   +1 more source

Mechanical force application to the nucleus regulates nucleocytoplasmic transport. [PDF]

Nat Cell Biol, 2022
Andreu I, Granero-Moya I, Chahare NR, Clein K, Molina-Jordán M, Beedle AEM, Elosegui-Artola A, Abenza JF, Rossetti L, Trepat X, Raveh B, Roca-Cusachs P.   +11 more
europepmc   +1 more source

The local mechanostructural properties of protein cargoes regulate nucleocytoplasmic transport. [PDF]

Nat Phys
Tapia-Rojo R, Milmoe N, Paracuellos P, Lally B, Escalona-López C, Masino L, Gehlen J, Walker J, Garcia-Manyes S.   +8 more
europepmc   +1 more source