Results 111 to 120 of about 27,476 (204)

OsbHLH064, an IVb bHLH Transcription Factor, Regulates Iron Homeostasis and Enhances Grain Fe Accumulation in Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT Iron (Fe) is an essential micronutrient for plant growth and development. The maintenance of Fe homeostasis relies on sophisticated regulatory networks where bHLH transcription factors play a key role. However, how these factors coordinate to regulate this vital process is not fully understood.
Fei Gao, Zhikai Zhu, Kaixin Xue, Zijing Fu, Jitong Yue, Na Zhang, Hongli Zhou, Yaqin Deng, Jing Zhou, Liuhui Kuang, Tao Yan, Lin Li, Christian Dubos, Dezhi Wu   +13 more
wiley   +1 more source

Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant‐Pathogen Interface

Plant Biotechnology Journal, EarlyView.
ABSTRACT The endoplasmic reticulum (ER) stress response, a conserved proteostasis network, has emerged as a central hub that reprograms plant immunity during pathogen attack. This review synthesises how plants harness ER‐stress signalling to mount multilayered defences and how pathogens have evolved counterstrategies to subvert these pathways.
Zhe Meng, Shuqin Zheng, Federica Brandizzi, Yiran Liu, Chunlei Li, Congcong Ai, Yujiao Wang, Jiadong Qi, Xiuguo Zhang   +8 more
wiley   +1 more source

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, EarlyView.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source

Sus1 Modulates Chromatin Remodeling and Gene Expression via the Cell Wall Integrity Pathway in Saccharomyces cerevisiae

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Cell wall stress in yeast triggers transcriptional reprogramming through the CWI pathway. This study identifies Sus1, a subunit of SAGA and TREX‐2, as a key regulator in this process. Sus1 associates with stress‐responsive genes, promoting pre‐initiation complex assembly, chromatin remodeling, and RNA Pol II progression independently of H2B ...
Mónica Pavón‐Vergés, Raúl García, José M. Rodríguez‐Peña, Ana Belén Sanz, Javier Arroyo   +4 more
wiley   +1 more source

Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology

Neurobiology of Disease
Alterations in transactivating response region DNA-binding protein 43 (TDP-43) are prevalent in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurological disorders.
Constance Zhou, Evelyn J. Hardin, Till S. Zimmer, Stephanie Jackvony, Daniel Barnett, Noopur Khobrekar, Elisa Giacomelli, Lorenz Studer, Adam L. Orr, Anna G. Orr   +9 more
doaj   +1 more source

A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nuclear size control.

PLoS Genetics, 2017
How cells control the overall size and growth of membrane-bound organelles is an important unanswered question of cell biology. Fission yeast cells maintain a nuclear size proportional to cellular size, resulting in a constant ratio between nuclear and ...
Kazunori Kume, Helena Cantwell, Frank R Neumann, Andrew W Jones, Ambrosius P Snijders, Paul Nurse   +5 more
doaj   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, Volume 16, Issue 5, Page 837-856, May 2026.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Nucleocytoplasmic transport blockage by SV40 peptide-modified gold nanoparticles induces cellular autophagy

International Journal of Nanomedicine, 2012
Tsung-Lin Tsai,1,5 Chia-Cheng Hou,1,5 Hao-Chen Wang,1,5 Zih-Syuan Yang,2 Chen-Sheng Yeh,4 Dar-Bin Shieh,2,3 Wu-Chou Su1,51Institute of Basic Medical Sciences, 2Institute of Oral Medicine and Department of Stomatology, 3Center for Micro/Nano Science and ...
Tsai TL, Hou CC, Wang HC, Yang ZS, Yeh CS, Shieh DB, Su WC   +6 more
doaj  

Structural Basis of Targeting the Exportin CRM1 in Cancer

Cells, 2015
Recent studies have demonstrated the interference of nucleocytoplasmic trafficking with the establishment and maintenance of various cancers. Nucleocytoplasmic transport is highly regulated and coordinated, involving different nuclear transport factors ...
Achim Dickmanns, Thomas Monecke, Ralf Ficner   +2 more
doaj   +1 more source

ARHI (DIRAS 3), an Imprinted Tumor Suppressor Gene, Binds to Importins, and Blocks Nuclear Translocation of Stat3 [PDF]

, 2008
ARHI (DIRAS3) is an imprinted tumor suppressor gene whose expression is lost in the majority of breast and ovarian cancers. Unlike its homologs Ras and Rap, ARHI functions as a tumor suppressor.
In Soon Chang, Ke Zhang, Robert Bast, Jr., Robert Luo, Shaoyi Huang, Tao Tao, Warren Liao, Wenbo Lin, Xiaomin Chen, Yiling Lu, Yinhua Yu, Zhen Lu   +11 more
core   +1 more source