Results 121 to 130 of about 27,476 (204)
Single molecule studies of nucleocytoplasmic transport
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011 Molecular traffic between the cytoplasm and the nucleoplasm of eukaryotic cells is mediated by nuclear pore complexes (NPCs). Hundreds, if not thousands, of molecules interact with and transit through each NPC every second. The pore is blocked by a permeability barrier, which consists of a network of intrinsically unfolded polypeptides containing ...
Tu, Li-Chun, Musser, Siegfried M.
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Advanced Science, Volume 13, Issue 25, 4 May 2026.Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song +4 more
wiley +1 more source
Frontiers in Genetics, 2019 Glioma is a common malignancy with poor prognosis. Recent evidence suggests that the pathogenesis and progression of glioma involve long noncoding RNAs (lncRNAs).
Rong Zheng +5 more
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The nucleocytoplasmic transport of viral proteins
Virologica Sinica, 2010 Molecules can enter the nucleus by passive diffusion or active transport mechanisms, depending on their size. Small molecules up to size of 50-60 kDa or less than 10 nm in diameter can diffuse passively through the nuclear pore complex (NPC), while most proteins are transported by energy driven transport mechanisms.
Qiong, Ding +3 more
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Brain and Behavior, Volume 16, Issue 5, May 2026.Hallmarks of brain aging regulated by microRNAs (miRNAs). This graphical abstract illustrates the central role of miRNAs in coordinating key biological processes associated with brain aging. miRNAs regulate multiple interconnected hallmarks, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis and impaired ...
Mustafa T. Ardah +7 more
wiley +1 more source
Nuclear Envelope Permeability Barrier as a Fast‐Response Intracellular Mechanostat
Advanced Science, 2019 The nuclear envelope is an undisputed component of the intracellular mechanotransduction cascades which collect, process, and respond to mechanical stimuli from the environment.
Victor Shahin +3 more
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Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.• XPO1 hyperactivation promotes leukaemogenesis by altering nucleocytoplasmic transport and transcriptional control in acute myeloid leukaemia (AML). • Selinexor and eltanexor show preferential activity in NPM1‐mutated, DEK::NUP214‐positive and SF3B1‐mutated myeloid neoplasms.
Yifan Liu +4 more
wiley +1 more source
Cell ReportsSummary: Nucleocytoplasmic transport defects are observed in Alzheimer's disease (AD) and frontotemporal dementia (FTD). Here, we assess mRNA nucleocytoplasmic localization by performing transcriptome-wide profiling on nuclear and cytoplasmic fractions ...
Christy Hung +6 more
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Subcellular partitioning of MRP RNA assessed by ultrastructural and biochemical analysis. [PDF]
, 1994 A small RNA encoded within the nucleus is an essential subunit of a RNA processing endonuclease (RNase MRP) hypothesized to generate primers for mitochondrial DNA replication from the heavy strand origin of replication.
Gonzalez, M +6 more
core
Protein Science, Volume 35, Issue 5, May 2026.Abstract The histone fold is one of the most ancient and versatile structural motifs in protein biology, best known for its role in chromatin organization. A remarkable variation of this motif is the double histone fold (DHF), in which two histone folds are encoded within a single polypeptide chain and assemble intramolecularly into a histone‐like ...
Anna Ranaudo +3 more
wiley +1 more source