Results 81 to 90 of about 2,127,287 (180)
The role of nucleocytoplasmic transport in mechanotransduction
, 2019 Cells integrate mechanical and biochemical signals via a process called mechanotransduction to generate essential gene expression patterns in space and time.
Lim, Roderick Y. H. +2 more
core +1 more source
Assessing Nucleocytoplasmic transport in Spinocerebellar Ataxia type 7
, 2021 SCA7 is an autosomal dominant CAG/polyglutamine trinucleotide repeat expansion disease that accounts for ~4% of all spinocerebellar ataxias in the USA.
Macopson Jones, Joshua
core +1 more source
RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging
Biological Reviews, EarlyView.ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad +5 more
wiley +1 more source
Ubiquitin-related modifier SUMO1 and nucleocytoplasmic transport
, 2002 Small ubiquitin related modifier SUMO-1 and its homologs can be conjugated to a large number of cellular proteins. This involves an enzymatic cascade that resembles ubiquitination, and the modification can be reverted by isopeptidases.
Pichler, A. +3 more
core +1 more source
Transport outlook 2010: The potential for innovation [PDF]
, 2010 This paper provides evidence on and discussion of recent developments in global transport markets and analyzes what policies look most promising for stabilizing CO2-emissions from light-duty vehicles.
International Transport Forum, OECD
core +1 more source
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
Cells sense and respond to mechanical forces through mechanotransduction, which regulates processes in health and disease. In single adhesive cells, mechanotransduction involves the transmission of force from the extracellular matrix to the cell nucleus,
Granero Moya, Ignasi +12 more
core +1 more source
Kap-Centric control of nuclear pores based on promiscuous binding to FG nucleoporins [PDF]
, 2014 Nuclear pore complexes (NPCs) are remarkable molecular machines that perforate the nuclear envelope (NE) in eukaryotic cells and mediate the rapid bidirectional traffic of hundreds of proteins, ribonucleoproteins, and metabolites across the nuclear ...
Wagner, Raphael S.
core +1 more source
GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction
Interdisciplinary Medicine, EarlyView.Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao +10 more
wiley +1 more source
Nuclear Pore Complexes and Nucleocytoplasmic Transport: From Structure to Function to Disease.
, 2015 Nucleocytoplasmic transport is an essential cellular activity and occurs via nuclear pore complexes (NPCs) that reside in the double membrane of the nuclear envelope.
Fahrenkrog, Birthe +5 more
core +1 more source