Results 151 to 160 of about 2,216,606 (233)

Single molecule studies of nucleocytoplasmic transport

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
Molecular traffic between the cytoplasm and the nucleoplasm of eukaryotic cells is mediated by nuclear pore complexes (NPCs). Hundreds, if not thousands, of molecules interact with and transit through each NPC every second. The pore is blocked by a permeability barrier, which consists of a network of intrinsically unfolded polypeptides containing ...
Tu, Li-Chun, Musser, Siegfried M.
openaire   +2 more sources

Tooth–bone attachment tissue is produced by cells with a mixture of odontoblastic and osteoblastic features in reptiles

Journal of Anatomy, Volume 248, Issue 2, Page 251-268, February 2026.
Tooth attachment in vertebrates ranges from ligament‐based anchorage in mammals to direct fusion in many reptiles. In the veiled chameleon, we identified a transient cell population—termed ankyloblasts—at the tooth‐bone interface. These cells exhibit both odontoblast‐ and osteoblast‐like features.
M. Šulcová, J. Dumková, B. Hutečková, M. Kavková, V. Parobková, O. Zahradníček, J. Křivánek, I. Adameyko, J. Kaiser, T. Zikmund, A. S. Tucker, M. Buchtová   +11 more
wiley   +1 more source

Mislocalization of nucleic acids is a convergent and targetable mechanism in Alzheimer's disease and frontotemporal dementia

Cell Reports
Summary: Nucleocytoplasmic transport defects are observed in Alzheimer's disease (AD) and frontotemporal dementia (FTD). Here, we assess mRNA nucleocytoplasmic localization by performing transcriptome-wide profiling on nuclear and cytoplasmic fractions ...
Christy Hung, Miriam Llorian, Koustav Pal, Frederick J. Livesey, Jyoti Choudhary, Theodoros I. Roumeliotis, Rickie Patani   +6 more
doaj   +1 more source

The nucleocytoplasmic transport of viral proteins

Virologica Sinica, 2010
Molecules can enter the nucleus by passive diffusion or active transport mechanisms, depending on their size. Small molecules up to size of 50-60 kDa or less than 10 nm in diameter can diffuse passively through the nuclear pore complex (NPC), while most proteins are transported by energy driven transport mechanisms.
Qiong, Ding, Lei, Zhao, Hong, Guo, Alan C, Zheng   +3 more
openaire   +3 more sources

Compartmentalised Function of TaHRC‐R Orchestrates ROS Production and Nuclear Condensate Dynamics

Molecular Plant Pathology, Volume 27, Issue 2, February 2026.
TaHRC‐R exerts dual functions by promoting ROS accumulation in the cytoplasm and modulating condensate formation of TaHRC‐S in the nucleus. The N‐terminal 21 amino acids and central region of TaHRC‐R are important for its nuclear export, heterodimerisation and ROS induction.
Yang Yang, Qingwen Li, Xin Ou, Tianyi Xue, Cong Jiang, Guanghui Wang, Ming Xu, Jie Liang   +7 more
wiley   +1 more source

Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses

Frontiers in Microbiology, 2015
Most viruses with non-segmented single stranded RNA genomes complete their life cycle in the cytoplasm of infected cells. However, despite undergoing replication in the cytoplasm, the structural proteins of some of these RNA viruses localize to the ...
Wahyu eWulan, Wahyu eWulan, Deborah eHeydet, Erin Joanne Walker, Michelle Elizabeth Gahan, Reena eGhildyal, Reena eGhildyal   +6 more
doaj   +1 more source

Acrolein Promotes Retinal Inflammation Through Macrophage Chemotaxis by Inducing CCL2 Production From Müller Cells

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Patients with proliferative diabetic retinopathy show elevated vitreous levels of the acrolein adduct FDP‐lys and CCL2. In rat Müller glial cells (TR‐MUL5), acrolein increases Ccl2 gene expression and CCL2 secretion and promotes macrophage migration.
Kanae Fukutsu, Miyuki Murata, Kasumi Kikuchi, Kousuke Noda, Susumu Ishida   +4 more
wiley   +1 more source

Perturbations in Traffic: Aberrant Nucleocytoplasmic Transport at the Heart of Neurodegeneration

Cells, 2018
Neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Huntington’s disease (HD), are characterized by intracellular aggregation of proteins.
B. Fahrenkrog, Amnon Harel
semanticscholar   +1 more source

From the trap to the basket: getting to the bottom of the nuclear pore complex [PDF]

, 2018
Nuclear pore complexes (NPCs) are large supramolecular assemblies that perforate the double-membraned nuclear envelope and serve as the sole gateways of molecular exchange between the cytoplasm and the nucleus in interphase cells.
Aebi, Ueli, Lim, Roderick, Stoffler, Daniel   +2 more
core  

Strategies for the Viral Exploitation of Nuclear Pore Transport Pathways

Viruses
Viruses frequently exploit the host’s nucleocytoplasmic trafficking machinery to facilitate their replication and evade immune defenses. By encoding specialized proteins and other components, they strategically target host nuclear transport receptors ...
Xin Zhang, Keesiang Lim, Yujia Qiu, Masaharu Hazawa, Richard W. Wong   +4 more
doaj   +1 more source