Results 11 to 20 of about 13,747 (162)
Quantitative Nucleocytoplasmic Transport Assays in Cellular Models of Neurodegeneration
Bio-Protocol, 2020 Nucleocytoplasmic transport deficits are suggested to play a role in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Given the importance and complexity of this process, understanding when these aberrations occur and which ...
Joni Vanneste +4 more
doaj +1 more source
Role of Nucleoporins and Transport Receptors in Cell Differentiation
Frontiers in Physiology, 2020 Bidirectional molecular movements between the nucleus and cytoplasm take place through nuclear pore complexes (NPCs) embedded in the nuclear membrane.
Asmat Ullah Khan +3 more
doaj +1 more source
Molecular profiling of nucleocytoplasmic transport factor genes in breast cancer
Heliyon, 2021 Transport of functional molecules across the nuclear membrane of a eukaryotic cell is regulated by a dedicated set of transporter proteins that carry molecules into the nucleus or out of the nucleus to the cytoplasm for homeostasis of the cell.
Rashid Mehmood +3 more
doaj +1 more source
Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy
Nature Communications, 2022 Missense variants in RNA-binding proteins underlie many diseases. Here the authors report an oculopharyngeal muscular dystrophy caused by heterozygous frameshift mutations in HNRNPA2B1 that alter its nucleocytoplasmic transport dynamics and result in ...
Hong Joo Kim +57 more
doaj +1 more source
Physical motif clustering within intrinsically disordered nucleoporin sequences reveals universal functional features. [PDF]
PLoS ONE, 2013 Bioinformatics of disordered proteins is especially challenging given high mutation rates for homologous proteins and that functionality may not be strongly related to sequence.
David Ando +3 more
doaj +1 more source
Frontiers in Microbiology, 2015 The respiratory diseases caused by Rhinovirus, Respiratory Syncytial Virus and Influenza virus represent a large social and financial burden on healthcare worldwide.
Leon eCaly +2 more
doaj +1 more source
Cells, 2021 Cancer remains a major public health concern, mainly because of the incompletely understood dynamics of molecular mechanisms for progression and resistance to treatments.
Mourad Zerfaoui +5 more
doaj +1 more source
Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses
Frontiers in Microbiology, 2015 Most viruses with non-segmented single stranded RNA genomes complete their life cycle in the cytoplasm of infected cells. However, despite undergoing replication in the cytoplasm, the structural proteins of some of these RNA viruses localize to the ...
Wahyu eWulan +6 more
doaj +1 more source
The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses
Cells, 2020 The transport of host proteins into and out of the nucleus is key to host function. However, nuclear transport is restricted by nuclear pores that perforate the nuclear envelope.
Jacinta M. Wubben +2 more
doaj +1 more source
Asian Journal of Andrology, 2015 Importin proteins were originally characterized for their central role in protein transport through the nuclear pores, the only intracellular entry to the nucleus.
Kate L. Loveland +5 more
doaj +1 more source