Results 1 to 10 of about 23,876 (290)

Lipid Droplets Are a Physiological Nucleoporin Reservoir [PDF]

Cells, 2021
Lipid Droplets (LD) are dynamic organelles that originate in the Endoplasmic Reticulum and mostly bud off toward the cytoplasm, where they store neutral lipids for energy and protection purposes.
Sylvain Kumanski, Benjamin T. Viart, Sofia Kossida, María Moriel-Carretero   +3 more
doaj   +4 more sources

The human nucleoporin Tpr protects cells from RNA-mediated replication stress

Nature Communications, 2021
Tpr nucleoporin is known to be essential for nuclear transport and mitosis processes. Here the authors explore the link between Tpr and genome instability providing insights into the role of Tpr in safeguarding cells from RNA-mediated replication stress.
Martin Kosar, Michele Giannattasio, Daniele Piccini, Apolinar Maya-Mendoza, Francisco García-Benítez, Jirina Bartkova, Sonia I. Barroso, Hélène Gaillard, Emanuele Martini, Umberto Restuccia, Miguel Angel Ramirez-Otero, Massimiliano Garre, Eleonora Verga, Miguel Andújar-Sánchez, Scott Maynard, Zdenek Hodny, Vincenzo Costanzo, Amit Kumar, Angela Bachi, Andrés Aguilera, Jiri Bartek, Marco Foiani   +21 more
doaj   +2 more sources

Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding

Nature Communications, 2020
The nuclear pore complex components, nucleoporins, have been proposed to mediate spatial and temporal organization of chromatin. Here, the authors show that Nucleoporin 153 interacts with CTCF and cohesin, and mediates their binding across cis-regulatory
Shinichi Kadota, Jianhong Ou, Yuming Shi, Jeannie T. Lee, Jiayu Sun, Eda Yildirim   +5 more
doaj   +3 more sources

The Human NUP58 Nucleoporin Can Form Amyloids In Vitro and In Vivo

Biomedicines, 2021
Amyloids are fibrillar protein aggregates with a cross-β structure and unusual features, including high resistance to detergent or protease treatment.
Lavrentii G. Danilov, Svetlana E. Moskalenko, Andrew G. Matveenko, Xenia V. Sukhanova, Mikhail V. Belousov, Galina A. Zhouravleva, Stanislav A. Bondarev   +6 more
doaj   +2 more sources

Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence [PDF]

PLoS Genetics, 2018
Nucleoporins build the nuclear pore complex (NPC), which, as sole gate for nuclear-cytoplasmic exchange, is of outmost importance for normal cell function.
Bonnin, Edith, Cabochette, Pauline, Dickmanns, Achim, Fahrenkrog, Birthe, Ficner, Ralf, Filosa, Alessandro, Hezwani, Mohammed, Hoffmann, Katrin, Janssens, Sandra, Jühlen, Ramona, Kehlenbach, Ralph H, Komatsuzaki, Shoko, Laing, Nigel G, Lammens, Martin, Lombard, Marcus, Martinelli, Valérie, Martins, Nuno, Pirenne, Laurence, Port, Sarah, Ravenscroft, Gianina, Roets, Ellen, Spillner, Christiane, Supply, Lynn, Van Dorpe, Jo, Vanhollebeke, Benoit, Vermeersch, Marjorie   +25 more
core   +4 more sources

An Arabidopsis Nucleoporin NUP85 modulates plant responses to ABA and salt stress. [PDF]

PLoS Genetics, 2017
Several nucleoporins in the nuclear pore complex (NPC) have been reported to be involved in abiotic stress responses in plants. However, the molecular mechanism of how NPC regulates abiotic stress responses, especially the expression of stress responsive
Yingfang Zhu, Bangshing Wang, Kai Tang, Chuan-Chih Hsu, Shaojun Xie, Hai Du, Yuting Yang, Weiguo Andy Tao, Jian-Kang Zhu   +8 more
doaj   +2 more sources

A physical model describing the interaction of nuclear transport receptors with FG nucleoporin domain assemblies

eLife, 2016
The permeability barrier of nuclear pore complexes (NPCs) controls bulk nucleocytoplasmic exchange. It consists of nucleoporin domains rich in phenylalanine-glycine motifs (FG domains). As a bottom-up nanoscale model for the permeability barrier, we have
R. Zahn, D. Osmanović, S. Ehret, Carolina Araya Callis, Steffen Frey, M. Stewart, C. You, D. Görlich, B. Hoogenboom, R. Richter   +9 more
semanticscholar   +2 more sources

Control of yeast retrotransposons mediated through nucleoporin evolution. [PDF]

PLoS Genetics, 2018
Yeasts serve as hosts to several types of genetic parasites. Few studies have addressed the evolutionary trajectory of yeast genes that control the stable co-existence of these parasites with their host cell.
Paul A Rowley, Kurt Patterson, Suzanne B Sandmeyer, Sara L Sawyer   +3 more
doaj   +2 more sources

The value of nucleoporin 188 in diagnosis, prognosis and immunoregulation: from pan-cancer analysis to gastric cancer verification. [PDF]

Front Immunol
Zhu Z, Peng R, Cai H.
europepmc   +2 more sources

Targeting Nucleoporin POM121-Importin β Axis in Prostate Cancer. [PDF]

Cell Chemical Biology, 2018
Keesiang Lim, R. Wong
semanticscholar   +2 more sources