Results 91 to 100 of about 23,876 (290)

Involvement in surface antigen expression by a moonlighting FG-repeat nucleoporin in trypanosomes [PDF]

, 2018
Components of the nuclear periphery coordinate a multitude of activities, including macromolecular transport, cell-cycle progression, and chromatin organization.
Acosta-Serrano A, Ahmed S, Akiyoshi B, Alexander V. Ratushny, Alsford S, Alsford S, Anne Spang, Bapteste E, Barth S, Bastin P, Brian T. Chait, Brun R, Budhraja V, Capelson M, Capitanio JS, Casolari JM, Chikne V, Clayton CE, Cronshaw JM, Daniels JP, Das A, deGrasse JA, Dieppois G, Dilworth DJ, duBois KN, Engstler M, Finn RD, Galy V, Galy V, Gravely BR, Guindon S, Gupta SK, Hirumi H, Ibarra A, Iouk T, Ishii K, Ismaïli N, Ismaïli N, Jean-Mathieu Bart, Jennifer M. Holden, John D. Aitchison, Kalverda B, Kasper LH, Katoh K, Kelly S, Kolev NG, Kramer S, Krull S, Kurshakova MM, Landeira D, Li H, Liang XH, Liang Y, Light WH, Ludek Koreny, Manger ID, Mark C. Field, Menon BB, Michael P. Rout, Miguel Navarro, Morchoisne-Bolhy S, Navarro M, Neumann N, Obado S, Oberholzer M, Ouellette M, Palenchar JB, Park JH, Rasband WS, Rout MP, Samson Obado, Schindelin J, Schwede A, Schwede A, Stanne TM, Tous C, Trapnell C, Utter CJ, Vaquerizas JM, Vassella E, Wei-Ming Chen, Wirtz E, Xu H, Yang X   +83 more
core   +2 more sources

The nucleoporin ELYS regulates nuclear size by controlling NPC number and nuclear import capacity

bioRxiv, 2019
How intracellular organelles acquire their characteristic sizes is a fundamental cell biological question. Given the stereotypical changes in nuclear size in cancer, it is particularly important to understand the mechanisms that control nuclear size in ...
P. Jevtić, Andria C. Schibler, Chase C Wesley, Gianluca Pegoraro, T. Misteli, D. Levy   +5 more
semanticscholar   +1 more source

Nucleoporin 210 Serves a Key Scaffold for SMARCB1 in Liver Cancer

Cancer Research, 2020
This study reveals a novel protumorigenic role for SMARCB1 and describes valuable links between nucleoporins and chromatin remodelers in cancer by identifying NUP210 as a critical coregulator of SMARCB1 chromatin remodeling activity.
S. Hong, K. Son, S. Ha, Tae In Wee, Sung Kyung Choi, Ji Eun Won, H. Han, Youngtae Ro, Yeong-Min Park, J. Eun, S. Nam, Jeung-Whan Han, Keunsoo Kang, J. You   +13 more
semanticscholar   +1 more source

Importins/Karyopherins Meet Nucleoporins [PDF]

Cell, 1996
I thank Gunter Blobel, Valerie Doye, Dirk Gorlich, Iain Mattaj, Ulf Nehrbass, and Uli Scheer for helpful comments on the manuscript.
openaire   +1 more source

Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity

eLife, 2015
Nuclear pore complexes (NPCs) conduct massive transport mediated by shuttling nuclear transport receptors (NTRs), while keeping nuclear and cytoplasmic contents separated.
Hermann Broder Schmidt, Dirk Görlich
doaj   +1 more source

Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast. [PDF]

, 2019
Production of healthy gametes in meiosis relies on the quality control and proper distribution of both nuclear and cytoplasmic contents. Meiotic differentiation naturally eliminates age-induced cellular damage by an unknown mechanism.
Chetlapalli, Keerthana, Goodman, Jay S, Jorgens, Danielle M, King, Grant A, McDonald, Kent L, Schick, Jennifer G, Ünal, Elçin   +6 more
core   +1 more source

Evidence for an evolutionary relationship between the large adaptor nucleoporin Nup192 and karyopherins [PDF]

, 2014
Nucleocytoplasmic transport is facilitated by nuclear pore complexes (NPCs), which are massive proteinaceous transport channels embedded in the nuclear envelope.
Collins, Leslie N., Hoelz, André, Hurt, Ed, Lin, Daniel H., Stuwe, Tobias   +4 more
core   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Cell type‐specific nuclear pores: a case in point for context‐dependent stoichiometry of molecular machines

Molecular Systems Biology, 2013
To understand the structure and function of large molecular machines, accurate knowledge of their stoichiometry is essential. In this study, we developed an integrated targeted proteomics and super‐resolution microscopy approach to determine the absolute
Alessandro Ori, Niccolò Banterle, Murat Iskar, Amparo Andrés‐Pons, Claudia Escher, Huy Khanh Bui, Lenore Sparks, Victor Solis‐Mezarino, Oliver Rinner, Peer Bork, Edward A Lemke, Martin Beck   +11 more
doaj   +1 more source

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

eLife, 2018
HIV-1 accesses the nuclear DNA of interphase cells via a poorly defined process involving functional interactions between the capsid protein (CA) and nucleoporins (Nups).
Melissa Kane, Stephanie V Rebensburg, Matthew A Takata, Trinity M Zang, Masahiro Yamashita, Mamuka Kvaratskhelia, Paul D Bieniasz   +6 more
doaj   +1 more source