Results 11 to 20 of about 23,876 (290)
The new nucleoporin: Regulator of transcriptional repression and beyond [PDF]
Nucleus, 2012 Transcriptional regulation is a complex process that requires the integrated action of many multi-protein complexes. The way in which a living cell coordinates the action of these complexes in time and space is still poorly understood.
Sarma, Nayan J, Willis, Kristine
core +6 more sources
Nucleoporin-mediated regulation of cell identity genes [PDF]
Genes & Development, 2016 Here, Ibarra et al. investigate the contribution of nuclear envelope components to the regulation of cell type-specific gene expression and show a role for NPC components in the regulation of cell type-specific gene expression The authors found that ...
Arkaitz Ibarra +4 more
semanticscholar +5 more sources
Nucleoporins facilitate ORC loading onto chromatin
Cell Reports, 2022 SUMMARYThe origin recognition complex (ORC) binds throughout the genome to initiate DNA replication. In metazoans, it is still unclear how ORC is targeted to specific loci to facilitate helicase loading and replication initiation. Here, we performed immunoprecipitations coupled with mass spectrometry for ORC2 in Drosophila embryos.
Logan Richards +4 more
openalex +3 more sources
Population diversity validation for Alzheimer's disease "unifying" models. [PDF]
Alzheimers DementAlzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Rudroff T.
europepmc +2 more sources
Nuclear Pores Assemble from Nucleoporin Condensates During Oogenesis [PDF]
Cell, 2019 Bernhard Hampoelz +8 more
semanticscholar +2 more sources
Correct dosage of X chromosome transcription is controlled by a nuclear pore component
Cell Reports, 2021 Summary: Dosage compensation in Drosophila melanogaster involves a 2-fold transcriptional upregulation of the male X chromosome, which relies on the X-chromosome-binding males-specific lethal (MSL) complex.
Jennifer R. Aleman +7 more
doaj +1 more source
Nucleoporin foci are stress‐sensitive condensates dispensable for C. elegans nuclear pore assembly
EMBO Journal, 2023 Nucleoporins (Nups) assemble nuclear pores that form the permeability barrier between nucleoplasm and cytoplasm. Nucleoporins also localize in cytoplasmic foci proposed to function as pore pre‐assembly intermediates. Here, we characterize the composition
Laura L Thomas +3 more
semanticscholar +1 more source
New Activities of the Nuclear Pore Complexes
Cells, 2021 Nuclear pore complexes (NPCs) at the surface of nuclear membranes play a critical role in regulating the transport of both small molecules and macromolecules between the cell nucleus and cytoplasm via their multilayered spiderweb-like central channel ...
Richard W. Wong
doaj +1 more source
Autophagy, 2022 Macroautophagy/autophagy is an essential process for cellular survival and is implicated in many diseases. A critical step in autophagy is the transport of the transcription factor TFEB from the cytosol into the nucleus, through the nuclear pore (NP) by ...
Shao-Ming Wang +7 more
semanticscholar +1 more source
Nucleoporin Nsp1 surveils the phase state of FG-Nups
bioRxiv, 2023 Transport through the NPC relies on intrinsically disordered FG-Nups forming a selective barrier. Away from the NPC, FG-Nups readily form condensates and aggregates, and we address how this behavior is surveilled in cells.
Tegan A. Otto +8 more
semanticscholar +1 more source