Results 31 to 40 of about 23,876 (290)
Altered localization of nucleoporin 98 in primary tauopathies
Brain Communications, 2022 Nucleoporin 98 is a nuclear pore complex component that is mislocalized in Alzheimer’s disease and the alteration in nucleoporin 98 has been attributed to tau.
J. Dickson, M. Frosch, B. Hyman
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Multifunctionality of F-rich nucleoporins [PDF]
Biochemical Society Transactions, 2020 Nucleoporins (Nups) represent a range of proteins most known for composing the macromolecular assembly of the nuclear pore complex (NPC). Among them, the family of intrinsically disordered proteins (IDPs) phenylalanine-glycine (FG) rich Nups, form the permeability barrier and coordinate the high-speed nucleocytoplasmic transport in a selective way ...
Nike Heinß +3 more
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Phosphorylation but Not Oligomerization Drives the Accumulation of Tau with Nucleoporin Nup98
International Journal of Molecular Sciences, 2022 Tau is a neuronal protein that stabilizes axonal microtubules (MTs) in the central nervous system. In Alzheimer’s disease (AD) and other tauopathies, phosphorylated Tau accumulates in intracellular aggregates, a pathological hallmark of these diseases ...
Lisa Diez +9 more
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Autoproteolysis in nucleoporin biogenesis [PDF]
Proceedings of the National Academy of Sciences, 1999 We have molecularly characterized a proteolytic cleavage in conserved nuclear pore complex proteins. This cleavage, previously demonstrated to be essential for the biogenesis of two nuclear pore complex proteins in mammals (Nup98 and Nup96) and yeast (Nup145-N and Nup145-C), occurs between Phe and Ser residues within a highly conserved ...
J S, Rosenblum, G, Blobel
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Nucleoporin genes in human diseases [PDF]
European Journal of Human Genetics, 2016 Nuclear pore complexes (NPCs) are large channels spanning the nuclear envelope that mediate nucleocytoplasmic transport. They are composed of multiple copies of ~30 proteins termed nucleoporins (NUPs). Alterations in NUP genes are linked to several human neoplastic and non-neoplastic diseases.
Valeria Nofrini +2 more
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Regulation of autophagy by nucleoporin Tpr [PDF]
Scientific Reports, 2012 The nuclear pore complex (NPC) consists of a conserved set of ~30 different proteins, termed nucleoporins, and serves as a gateway for the exchange of materials between the cytoplasm and nucleus. Tpr (translocated promoter region) is a component of NPC that presumably localizes at intranuclear filaments. Here, we show that Tpr knockdown caused a severe
Tatsuyoshi Funasaka +2 more
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SuperResNET: Model-Free Single-Molecule Network Analysis Software Achieves Molecular Resolution of Nup96. [PDF]
Adv Intell SystSuperResNET is a powerful integrated software that reconstructs network architecture and molecular distribution of subcellular structures from single molecule localization microscopy datasets. SuperResNET segments the nuclear pore complex and corners, extracts size, shape, and network features of all segmented nuclear pores and uses modularity analysis
Li YL +6 more
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eLife, 2023 The nucleoporin (NUP) ELYS, encoded by AHCTF1, is a large multifunctional protein with essential roles in nuclear pore assembly and mitosis. Using both larval and adult zebrafish models of hepatocellular carcinoma (HCC), in which the expression of an ...
Kimberly J Morgan +15 more
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Nucleoporin Nup62 maintains centrosome homeostasis [PDF]
Cell Cycle, 2013 Centrosomes are comprised of 2 orthogonally arranged centrioles surrounded by the pericentriolar material (PCM), which serves as the main microtubule organizing center of the animal cell. More importantly, centrosomes also control spindle polarity and orientation during mitosis.
Hashizume, Chieko +5 more
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NUP214 (nucleoporin 214kDa) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on NUP214 (nucleoporin 214kDa), with data on DNA, on the protein encoded, and where the gene is implicated.
Sabine Strehl
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