Results 41 to 50 of about 8,158 (226)
Viruses Challenge Selectivity Barrier of Nuclear Pores
Viruses, 2013 Exchange between the nucleus and the cytoplasm occurs through nuclear pore complexes (NPCs) embedded in the double membrane of the nuclear envelope. NPC permeability barrier restricts the entry of inert molecules larger than 5 nm in diameter but allows ...
Ariberto Fassati, Aksana A. Labokha
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Nuclear distributions of NUP62 and NUP214 suggest architectural diversity and spatial patterning among nuclear pore complexes. [PDF]
PLoS ONE, 2012 The shape of nuclei in many adherent cultured cells approximates an oblate ellipsoid, with contralateral flattened surfaces facing the culture plate or the medium.
Yayoi Kinoshita +3 more
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Gene Regulation by Nucleoporins and Links to Cancer [PDF]
Molecular Cell, 2010 Nuclear pore complexes (NPCs) composed of approximately 30 individual nucleoporins form huge macromolecular assemblies in the nuclear envelope, through which bidirectional cargo movement between the nucleus and cytoplasm occurs. Beyond their transport function, NPCs can serve as docking sites for chromatin and thereby contribute to the organization of ...
Ed Hurt, Alwin Köhler
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Rae1: A new clue for nucleoporin leukemias [PDF]
Cell Cycle, 2011 N/A ; © 2011 Landes Bioscience.
Stuwe, Tobias, Hoelz, André
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Disease Models & Mechanisms, 2022 Nucleoporin 98KD (Nup98) is a promiscuous translocation partner in hematological malignancies. Most disease models of Nup98 translocations involve ectopic expression of the fusion protein under study, leaving the endogenous Nup98 loci unperturbed ...
Ajai J. Pulianmackal +6 more
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NUP98 (nucleoporin 98 kDa) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2010 Review on NUP98 (nucleoporin 98 kDa), with data on DNA, on the protein encoded, and where the gene is implicated.
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In Pursuit of Distinctiveness: Transmembrane Nucleoporins and Their Disease Associations [PDF]
Frontiers in Oncology, 2021 The bi-directional nucleocytoplasmic shuttling of macromolecules like molecular signals, transcription factors, regulatory proteins, and RNAs occurs exclusively through Nuclear Pore Complex (NPC) residing in the nuclear membrane. This magnanimous complex is essentially a congregation of ~32 conserved proteins termed Nucleoporins (Nups) present in ...
Divya Bindra, Ram Kumar Mishra
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Importins/Karyopherins Meet Nucleoporins [PDF]
Cell, 1996 I thank Gunter Blobel, Valerie Doye, Dirk Gorlich, Iain Mattaj, Ulf Nehrbass, and Uli Scheer for helpful comments on the manuscript.
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Linking Nucleoporins, Mitosis, and Colon Cancer [PDF]
Cell Chemical Biology, 2016 Suppression of a nuclear pore protein Nup358/RanBP2 is linked to mitotic cell death, but the clinical relevance of this link is unknown. In a recent issue of Cell, Vecchione et al. (2016) show that in approximately 10% of BRAF-like colorectal cancer (CC) patients, Nup358/RanBP2 is critical for survival.
Maximiliano A. D'Angelo, Richard W. Wong
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eLife, 2019 We previously demonstrated that CRM1, a major nuclear export factor, accumulates at Hox cluster regions to recruit nucleoporin-fusion protein Nup98HoxA9, resulting in robust activation of Hox genes (Oka et al., 2016).
Masahiro Oka +9 more
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