Results 81 to 90 of about 8,158 (226)
Nucleoporins facilitate ORC loading onto chromatin
Cell Reports, 2022 SUMMARYThe origin recognition complex (ORC) binds throughout the genome to initiate DNA replication. In metazoans, it is still unclear how ORC is targeted to specific loci to facilitate helicase loading and replication initiation. Here, we performed immunoprecipitations coupled with mass spectrometry for ORC2 in Drosophila embryos.
Logan Richards +4 more
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Phase Separation Regulates Metabolism, Mitochondria, and Diseases
MedComm, Volume 6, Issue 7, July 2025.Mitochondrion‐related liquid–liquid phase separation. (1) Phase separation mediates the self‐assembly of mitochondrial nucleoids (mt‐nucleoids). (2) Phase segregation mediates the formation of mitochondrial RNA granules (MRGs). (3) Phase separation mediates the formation of mitochondrial degradosomes.
Chuan Gao +3 more
wiley +1 more source
Cytoplasmic nucleoporin assemblage: the cellular artwork in physiology and disease
NucleusNucleoporins, essential proteins building the nuclear pore, are pivotal for ensuring nucleocytoplasmic transport. While traditionally confined to the nuclear envelope, emerging evidence indicates their presence in various cytoplasmic structures ...
Junyan Lin, Izabela Sumara
doaj +1 more source
Nucleoporin-mediated regulation of cell identity genes [PDF]
Genes & Development, 2016 The organization of the genome in the three-dimensional space of the nucleus is coupled with cell type-specific gene expression. However, how nuclear architecture influences transcription that governs cell identity remains unknown. Here, we show that nuclear pore complex (NPC) components Nup93 and Nup153 bind superenhancers (SE), regulatory structures ...
Ibarra, Arkaitz +4 more
openaire +5 more sources
The FEBS Journal, Volume 292, Issue 11, Page 2715-2736, June 2025.The silencing of transposable elements is mediated by piRNAs through post‐transcriptional and transcriptional regulation. In Drosophila, piRNAs are processed within unique non‐membrane structures: nuage in germline cells and Yb bodies in somatic gonadal cells.
Ritsuko Suyama, Toshie Kai
wiley +1 more source
Importin 7 and Nup358 promote nuclear import of the protein component of human telomerase.
PLoS ONE, 2014 In actively dividing eukaryotic cells, chromosome ends (telomeres) are subject to progressive shortening, unless they are maintained by the action of telomerase, a dedicated enzyme that adds DNA sequence repeats to chromosomal 3'end.
Cornelia Frohnert +4 more
doaj +1 more source
MINFLUX Nanoscopy: A “Brilliant” Technique Promising Major Breakthrough
Microscopy Research and Technique, Volume 88, Issue 5, Page 1264-1272, May 2025.Minflux localization microscopy technique allows for both nm‐scale resolution in imaging and up to 10 kHz speed in tracking of single molecules. ABSTRACT MINFLUX nanoscopy relies on the localization of single fluorophores with expected ~ 2 nm precision in 3D mapping, roughly one order of magnitude better than standard stimulated emission depletion ...
Marco Salerno +6 more
wiley +1 more source
Nucleoporin Gene Fusions and Hematopoietic Malignancies [PDF]
New Journal of Science, 2014 Nuclear pore complexes (NPCs) are the sole gateways between the nucleus and the cytoplasm of eukaryotic cells and they mediate all macromolecular trafficking between these cellular compartments. Nucleocytoplasmic transport is highly selective and precisely regulated and as such an important aspect of normal cellular function. Defects in this process or
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A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits
Nature Communications, 2018 The nuclear pore complex is crucial for mediating nucleocytoplasmic exchanges. Here the authors use budding yeast to reveal a mechanism responsible of maintaining nucleoporin homeostasis by sensing changes in the complex integrity and further altering ...
Jérôme O. Rouvière +5 more
doaj +1 more source
NUP98 (nucleoporin 98 kDa) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on NUP98 (nucleoporin 98 kDa), with data on DNA, on the protein encoded, and where the gene is implicated.
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