Results 81 to 90 of about 23,876 (290)

Misregulation of Nucleoporins 98 and 96 leads to defects in protein synthesis that promote hallmarks of tumorigenesis

Disease Models & Mechanisms, 2022
Nucleoporin 98KD (Nup98) is a promiscuous translocation partner in hematological malignancies. Most disease models of Nup98 translocations involve ectopic expression of the fusion protein under study, leaving the endogenous Nup98 loci unperturbed ...
Ajai J. Pulianmackal, Kiriaki Kanakousaki, Kerry Flegel, Olga G. Grushko, Ella Gourley, Emily Rozich, Laura A. Buttitta   +6 more
doaj   +1 more source

Homeobox genes in normal and abnormal vasculogenesis [PDF]

, 2008
Homeobox containing genes are a family of transcription factors regulating normal development and controlling primary cellular processes (cell identity, cell division and differentiation) recently enriched by the discovery of their interaction with ...
Cantile M, CILLO, CLEMENTE, Schiavo G, Terracciano L   +3 more
core   +1 more source

Agrobacterium-delivered VirE2 interacts with host nucleoporin CG1 to facilitate the nuclear import of VirE2-coated T complex

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Molecular trafficking into nuclei is essential for eukaryotic cells. However, it is not clear how a large linear protein complex enters the nucleus in a natural setting.
Xiaoyang Li, Qinghua Yang, Ling-Tao Peng, Haitao Tu, Lan-Ying Lee, S. Gelvin, S. Pan   +6 more
semanticscholar   +1 more source

Shaping the p53 Response with Nucleoporins [PDF]

Molecular Cell, 2012
In this issue, Singer et al. (2012) reveal that the nucleoporin Nup98 supports adaptation to genotoxic stress by protecting specific p53-induced mRNAs from exosome-dependent degradation, suggesting that wild-type Nup98 may possess tumor suppressor function.
Yarbrough, Melanie L., White, Michael A., Fontoura, Beatriz M.A.   +2 more
openaire   +2 more sources

Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through NUP62, inhibiting host nucleocytoplasmic transport pathways [PDF]

, 2012
The herpes simplex virus ICP27 protein is important for the expression and nuclear export of viral mRNAs. Although several binding sites have been mapped along the ICP27 sequence for various RNA and protein partners including the transport receptor TAP ...
Arnold, Aubert, Bachi, Bonifaci, Braun, Bryant, Chen, Chen, Copeland, Cullen, Darshan, Ellison, Ellison, Escudero-Paunetto, Faria, Fischer, Flach, Fontaine-Rodriguez, Fontoura, Fornerod, Fridell, Gerace, Gruffat, Grüter, Gustin, Gustin, Gustin, Han, Hardwicke, Hernandez, Hiriart, Hofemeister, Hutten, Johnson, Kambach, Koffa, Larralde, Lengyel, Lengyel, Li, Lilley, Long, Macaulay, Malik, Malik, McCarthy, Mears, Mears, Mears, Meyer, Michael, Nelson, Park, Pasdeloup, Pasquinelli, Pearson, Pellet, Petersen, Phelan, Piñol-Roma, Pollard, Pritchard, Rice, Rice, Rice, Rice, Rojas, Saavedra, Sandri-Goldin, Satterly, Schmitt, Sekulovich, Siomi, Smith, Soliman, Soliman, Souki, Strambio-De-Castillia, Strässer, Tsuji, Wagstaff, Wente, Zhi, Zhi   +83 more
core   +3 more sources

NUP98 (nucleoporin 98 kDa) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2010
Review on NUP98 (nucleoporin 98 kDa), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +3 more sources

Nuclear Import of Hepatitis B Virus Capsids and Genome

Viruses, 2017
Hepatitis B virus (HBV) is an enveloped pararetrovirus with a DNA genome, which is found in an up to 36 nm-measuring capsid. Replication of the genome occurs via an RNA intermediate, which is synthesized in the nucleus.
Lara Gallucci, Michael Kann
doaj   +1 more source

SCARB1 downregulation in adrenal insufficiency with Allgrove syndrome

Orphanet Journal of Rare Diseases, 2023
Background Allgrove disease is a rare genetic syndrome characterized by adrenal insufficiency, alacrimia, achalasia and complex neurological involvement.
Giacomo Bitetto, Gianluca Lopez, Dario Ronchi, Alessandra Pittaro, Valentina Melzi, Erika Peverelli, Fulvia Milena Cribiù, Giacomo P. Comi, Giovanna Mantovani, Alessio Di Fonzo   +9 more
doaj   +1 more source

Gene gating at nuclear pores prevents the formation of R loops [PDF]

, 2017
Transcription is an important source of genetic variability. A large amount of transcription-associated genome variation arises from the unscheduled formation of R loops.
Aguilera López, Andrés, Gaillard, Hélène, García Benítez, Francisco   +2 more
core   +1 more source

Nuclear Pore Proteins in Regulation of Chromatin State

Cells, 2019
Nuclear pore complexes (NPCs) are canonically known to regulate nucleocytoplasmic transport. However, research efforts over the last decade have demonstrated that NPCs and their constituent nucleoporins (Nups) also interact with the genome and perform ...
Terra M. Kuhn, Maya Capelson
doaj   +1 more source