Results 121 to 130 of about 61,031 (268)

Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009

mSphere, 2018
Influenza A viruses (IAVs) can cause zoonotic infections with pandemic potential when most of the human population is immunologically naive. After a pandemic, IAVs evolve to become seasonal in the human host by acquiring adaptive mutations.
Isabel Pagani, Andrea Di Pietro, Alexandra Oteiza, Michela Ghitti, Nadir Mechti, Nadia Naffakh, Elisa Vicenzi   +6 more
doaj   +1 more source

Nucleoprotein Autoantibodies in Lupus Erythematosus

Journal of Investigative Dermatology, 1985
Autoantibodies against deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) proteins are commonly detected in patients with lupus erythematosus (LE). Antibodies against native DNA are frequently detected in a subset of LE patients with a high prevalence of renal disease.
Provost, Thomas T., Herrera-Esparza, Rafael, Diaz, Luis A.   +2 more
openaire   +2 more sources

Dual Host–Pathogen Screening of the Lung During Severe Influenza Using Spatial Transcriptomics

Immunology &Cell Biology, EarlyView.
We performed genome‐wide spatial transcriptomics at 10 μm resolution on the lungs of mice infected with influenza A virus. We utilised publicly available scRNAseq reference datasets to identify cell types present. We found viral transcripts across all detected cell types, suggesting localised indiscriminate infection.
Marcus Z. W. Tong, Oliver P. Skinner, Chen Zhu, Brooke J. Wanrooy, Ashlyn S. Kerr, Zheng Ruan, Cameron G. Williams, Heran Zhang, Linda M. Wakim, Ashraful Haque   +9 more
wiley   +1 more source

CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication

mBio, 2017
Influenza A virus (IAV) RNA segments are individually packaged with viral nucleoprotein (NP) and RNA polymerases to form a viral ribonucleoprotein (vRNP) complex.
Yu-Chen Lin, King-Song Jeng, Michael M. C. Lai   +2 more
doaj   +1 more source

Pro283 disrupts nucleoprotein α-helical content and is destabilizing relative to other variants at site 283.

, 2018
(A) Nucleoprotein crystal structure reveals site 283 is in the center of an α-helix (PDB ID: 2IQH [36]). (B) Molecular dynamics simulations show that Pro283 disrupts nucleoprotein α-helical content compared to Ser283.
Jesse D. Bloom (347889), Orr Ashenberg (236602), Vincent L. Butty (449351), Angela M. Phillips (5753726), Christopher L. Moore (4919812), Yu-Shan Lin (519689), Anna I. Ponomarenko (5753729), Matthew D. Shoulders (1323849), Jiayuan Miao (5753732), Sean M. McHugh (2607055), Charles A. Whittaker (451896), Kenny Chen (3524972)   +11 more
core   +1 more source

Metagenomic detection and characterization of RNA viruses associated with Rhipicephalus linnaei (Audouin, 1826) ticks from the Amazon, Pará, Brazil

Medical and Veterinary Entomology, EarlyView.
Metagenomic analysis of Rhipicephalus linnaei from the Brazilian Amazon revealed the presence of RNA viruses belonging to the families Chuviridae, Phenuiviridae, Orthomyxoviridae and Rhabdoviridae. This study reports the first detection of Brown dog tick mivirus 1 and Brown dog tick phlebovirus 2 in Brazil, based on genomic characterization and ...
Lucas Henrique da Silva e Silva, Sandro Patroca da Silva, Fábio Silva da Silva, Leonardo Henrique Almeida Hernández, Daniel Damous Dias, Sâmia Luzia Sena da Silva, Lúcia Aline Moura Reis, Hanna Carolina Farias Reis, Bruna Laís Sena do Nascimento, Roberto Carlos Feitosa Brandão, Durval Bertram Rodrigues Vieira, Bruno Tardelli Diniz Nunes, Ana Cecília Ribeiro Cruz, Joaquim Pinto Nunes Neto   +13 more
wiley   +1 more source

Rice Orange Leaf Phytoplasma Imp Protein Blocks G–M Interaction by Binding Glycoprotein G to Suppress Rice Stripe Mosaic Virus Infection

Plant, Cell &Environment, EarlyView.
ABSTRACT Plants frequently encounter multiple pathogens concurrently, yet the molecular bases of pathogen–pathogen interactions during mixed infections remain largely unresolved. Here we show that co‐infection of rice by Rice orange leaf phytoplasma (ROLP) and Rice stripe mosaic virus (RSMV) markedly suppresses RSMV proliferation in both host plants ...
Jiaxin Qiu, Yujiao Zheng, Yanmei Yi, Yuxin Zhang, Tianbao Zeng, Hongyan Chen, Taiyun Wei, Xiao‐Feng Zhang   +7 more
wiley   +1 more source

On a nucleoprotein isolated from human and animal tissue with collagen-precipitating properties. II. The collagen-precipitating properties of the nucleoprotein

, 1966
Das in der I. Mitteilung beschriebene Nucleoprotein führt bei Zugabe zu Tropokollagen-Lösungen zur Bildung von kollagenen Fibrillen. Die Fibrillen-bildende Potenz des Nucleoproteins ist sehr groß.
Wilhelm, G.
core   +1 more source

Cardiometabolic Complications in Pregnancy and Biological Ageing in the Offspring: A Systematic Review and Meta‐Analysis

Paediatric and Perinatal Epidemiology, EarlyView.
ABSTRACT Background Cardiometabolic complications in pregnancy may alter the intrauterine environment, influence offspring biological ageing and potentially increase the risk of chronic diseases later in life. Objectives This systematic review and meta‐analysis aimed to examine associations between diabetes in pregnancy, hypertensive disorders of ...
Eskedar Getie Mekonnen, Tina Bianco‐Miotto, Kai Liu, Jessica A. Grieger   +3 more
wiley   +1 more source

Reactogenicity and Immunogenicity of RSV Vaccines in Immunocompromised Individuals With Hematological Malignancies

Transplant Infectious Disease, EarlyView.
In adults with hematologic malignancies, RSV vaccination was safe and induced antibody and T‐cell responses. However, antibody levels were lower and declined more rapidly than in healthy controls. While early immune responses were evident, reduced magnitude and durability of protection suggest the need for optimized vaccination strategies in this high ...
Alisse Hannaford, Zoe Swank, Simon D. van Haren, Natalie Izaguirre, Caitlin Syphurs, Zhou Lan, Bridget Yates, Urwah Kanwal, Grace Valentine, Ella Woehl, David Regan, Hannah Levine, Alexandra Tong, Maria Shehata, Fathia Oladipupo, Colleen Sedney, Kevin Ryff, Sanya Thomas, Joann Diray‐Arce, Xiaofang Li, Kimberly A. Dufresne, Lindsey A. Parisi, Aidan Eustace, Louise Hansen, David R. Walt, Ofer Levy, Amar Kelkar, Robert J. Soiffer, Vincent T. Ho, Lindsey R. Baden, Nicolas C. Issa, Ann E. Woolley, Amy C. Sherman   +32 more
wiley   +1 more source