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Nucleosome—nucleosome interaction in chromatin
FEBS Letters, 1979 The available data suggest that transcriptional activity of chromatin is connected with its structural changes [ 1,2]. According to the electron microscope evidence, the elementary 100 A chromatin thread can exist in two main states, i.e., in a compact state, which is characterized by tight packing of nucleosomes and in an extended state when the ...
S. B. Svetlikova +2 more
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Circulating Nucleosomes and Nucleosome Modifications as Biomarkers in Cancer [PDF]
Cancers, 2017 Traditionally the stratification of many cancers involves combining tumour and clinicopathological features (e.g., patient age; tumour size, grade, receptor status and location) to inform treatment options and predict recurrence risk and survival. However, current biomarkers often require invasive excision of the tumour for profiling, do not allow ...
Peter McAnena +2 more
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BMC Genomics, 2009 Background The nucleosome is the fundamental unit of eukaryotic genomes. Its positioning plays a central role in diverse cellular processes that rely on access to genomic DNA.
Wang Jiang +6 more
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Nature Communications, 2020 Liquid–liquid phase separation (LLPS) is an important mechanism that helps explain the membraneless compartmentalization of the nucleus. Because chromatin compaction and LLPS are collective phenomena, linking their modulation to the physicochemical ...
Stephen E. Farr +4 more
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Science Advances, 2015 Reestablishment of the nucleosome landscape behind the replication fork is fundamental for epigenetic memory during development.
Ramachandran, Srinivas, Henikoff, Steven
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High nucleosome occupancy is encoded at human regulatory sequences. [PDF]
PLoS ONE, 2010 Active eukaryotic regulatory sites are characterized by open chromatin, and yeast promoters and transcription factor binding sites (TFBSs) typically have low intrinsic nucleosome occupancy. Here, we show that in contrast to yeast, DNA at human promoters,
Desiree Tillo +9 more
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Crystal structures of heterotypic nucleosomes containing histones H2A.Z and H2A [PDF]
Open Biology, 2016 H2A.Z is incorporated into nucleosomes located around transcription start sites and functions as an epigenetic regulator for the transcription of certain genes.
Naoki Horikoshi +3 more
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HP1 reshapes the nucleosome core to promote phase separation of heterochromatin
Nature, 2019 Heterochromatin affects genome function at many levels. It enables heritable gene repression, maintains chromosome integrity and provides mechanical rigidity to the nucleus1,2.
S. Sanulli +8 more
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Chromatin—a global buffer for eukaryotic gene control
AIMS Biophysics, 2015 Most of eukaryotic DNA is embedded into nucleosome arrays formed by DNA wrapped around a core histone octamer. Nucleosome is a fundamental repeating unit of chromatin guarding access to the genetic information.
Yuri M. Moshkin
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Manipulating chromatin architecture in C. elegans
Epigenetics & Chromatin, 2022 Background Nucleosome-mediated chromatin compaction has a direct effect on the accessibility of trans-acting activators and repressors to DNA targets and serves as a primary regulatory agent of genetic expression. Understanding the nature and dynamics of
John L. Carter +3 more
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