Results 91 to 100 of about 156,001 (374)

Cell cycle-specified fluctuation of nucleosome occupancy at gene promoters.

PLoS Genetics, 2006
The packaging of DNA into nucleosomes influences the accessibility of underlying regulatory information. Nucleosome occupancy and positioning are best characterized in the budding yeast Saccharomyces cerevisiae, albeit in asynchronous cell populations or
Gregory J Hogan, Cheol-Koo Lee, Jason D Lieb   +2 more
doaj   +1 more source

The physics of epigenetics

, 2016
In higher organisms, all cells share the same genome, but every cell expresses only a limited and specific set of genes that defines the cell type. During cell division, not only the genome, but also the cell type is inherited by the daughter cells. This
Barbi, Maria, Caré, Bertrand R., Cortini, Ruggero, Lavelle, Christophe, Lesne, Annick, Mozziconacci, Julien, Victor, Jean-Marc   +6 more
core   +3 more sources

Theoretical analysis of the role of chromatin interactions in long-range action of enhancers and insulators [PDF]

, 2011
Long-distance regulatory interactions between enhancers and their target genes are commonplace in higher eukaryotes. Interposed boundaries or insulators are able to block these long distance regulatory interactions.
A. M. Sengupta, Arya, Banzhaf, Blackwood, Bondarenko, Bushey, Bustin, Capelson, Carter, Chodaparambil, Corces, Cremer, Cui, Dekker, Dorsett, Gerasimova, Geyer, Geyer, Hahnfeldt, Langowski, Luger, Moore, Nielsen, Nobrega, P. Schedl, Phair, Polikanov, Rochman, S. Mukhopadhyay, Savitskaya, Schermelleh, Simonis, Tolhuis, V. M. Studitsky, Valenzuela, van den Engh, Wallace, West, Zheng, Zhou   +39 more
core   +3 more sources

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure. [PDF]

PLoS Genetics, 2010
Eukaryotic DNA replication origins differ both in their efficiency and in the characteristic time during S phase when they become active. The biological basis for these differences remains unknown, but they could be a consequence of chromatin structure ...
Nicolas M Berbenetz, Corey Nislow, Grant W Brown   +2 more
doaj   +1 more source

DNA Spools under Tension

, 2003
DNA-spools, structures in which DNA is wrapped and helically coiled onto itself or onto a protein core are ubiquitous in nature. We develop a general theory describing the non-equilibrium behavior of DNA-spools under linear tension.
C. G. Baumann, E. Evans, E. Evans, H. Schiessel, H. Yin, I. M. Kulić, J. F. Marko, K. B. Thurmond, R. Bruinsma   +8 more
core   +1 more source

Nucleosomes in serum as a marker for cell death [PDF]

, 2001
The concentration of nucleosomes is elevated in blood of patients with diseases which are associated with enhanced cell death. In order to detect these circulating nucleosomes, we used the Cell Death Detection-ELISA(Plus) (CDDE) from Roche Diagnostics ...
Anker P, Arends MJ, Burlingame RW, Du Clos TW, Emlen W, Gauthier VJ, Holdenrieder S, Jahr S, Leist M, Leon SA, Maebo A, Majno G, Mannherz HG, Rumore P, Stroun M, Watson RW   +15 more
core   +1 more source

The DNA-encoded nucleosome organization of a eukaryotic genome

Nature, 2009
Nucleosome organization is critical for gene regulation. In living cells this organization is determined by multiple factors, including the action of chromatin remodellers, competition with site-specific DNA-binding proteins, and the DNA sequence ...
Noam Kaplan, Irene K. Moore, Yvonne N. Fondufe-Mittendorf, A. Gossett, Desiree Tillo, Yair Field, E. Leproust, T. Hughes, J. Lieb, J. Widom, E. Segal   +10 more
semanticscholar   +1 more source

Asymmetrically Modified Nucleosomes [PDF]

Cell, 2012
Mononucleosomes, the basic building blocks of chromatin, contain two copies of each core histone. The associated posttranslational modifications regulate essential chromatin-dependent processes, yet whether each histone copy is identically modified in vivo is unclear.
Voigt, Philipp, LeRoy, Gary, Drury, William J., Zee, Barry M., Son, Jinsook, Beck, David B., Young, Nicolas L., Garcia, Benjamin A., Reinberg, Danny   +8 more
openaire   +2 more sources

Foundation Model‐Enabled Multimodal Deep Learning for Prognostic Prediction in Colorectal Cancer with Incomplete Modalities: A Multi‐Institutional Retrospective Study

Advanced Science, EarlyView.
FLARE, a multimodal AI framework, combines pathology slides, radiology scans, and clinical reports to predict colorectal cancer outcomes, even when some tests are missing. Evaluated retrospectively in 1679 patients from four medical centers, it consistently achieved the best prognostic accuracy and clearly separated high‐ and low‐risk groups.
Linhao Qu, Chengsheng Zhang, Yingyong Hou, Feng Tang, Weiqi Sheng, Dan Huang, Zhijian Song   +6 more
wiley   +1 more source