Results 91 to 100 of about 141,257 (371)

Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes [PDF]

, 2006
ISWI proteins form the catalytic core of a subset of ATP-dependent chromatin remodelling activities in eukaryotes from yeast to man. Many of these complexes have been found to reposition nucleosomes, but with different directionalities.
Alen, Beard, Becker, Brehm, Bruno, Bruno, Davey, Dillingham, Drew, Eberharter, Elfring, Fazzio, Flaus, Flaus, Flaus, Hamiche, Kagalwala, Kang, Kassabov, Langst, Lorch, Lowary, Luger, Lusser, Meersseman, Mizuguchi, Morillon, Rigaut, Schnitzler, Tran, Tsukiyama, Tsukiyama, Vary, Zofall   +33 more
core   +3 more sources

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

Advanced Science, EarlyView.
This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz, Anupam Banerjee, Xin Cui, Lidan Zeng, Amad Uddin, Christopher Li, Yueming Zhu, Mengyuan Zhang, Xiaodong Lu, Nagendra S. Yarla, Lu Wang, Jindan Yu, Jonathan C. Zhao, Ivet Bahar, Yong Wan   +14 more
wiley   +1 more source

Structure of SWI/SNF chromatin remodeler RSC bound to a nucleosome

Nature, 2019
Chromatin-remodelling complexes of the SWI/SNF family function in the formation of nucleosome-depleted, transcriptionally active promoter regions (NDRs)1,2.
F. R. Wagner, C. Dienemann, Haibo Wang, A. Stuetzer, D. Tegunov, H. Urlaub, P. Cramer   +6 more
semanticscholar   +1 more source

Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms [PDF]

, 2007
Alteration of chromatin structure by chromatin modifying and remodelling activities is a key stage in the regulation of many nuclear processes. These activities are frequently interlinked, and many chromatin remodelling enzymes contain motifs that ...
Ferreira, Helder, Flaus, Andrew, Owen-Hughes, Tom   +2 more
core   +3 more sources

Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets

Advanced Science, EarlyView.
This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu, Peng Peng, Yi‐Ning Wang, Mao‐Yang He, Shuang He, Chen‐Tao Jin, Liu Yang, Xi Wang, Jia‐Xi Zheng, Jie Gao, Cheng‐Ran Xu   +10 more
wiley   +1 more source

Structural basis of the nucleosome transition during RNA polymerase II passage

Science, 2018
Nucleosomal DNA transcription In eukaryotes, the basic chromatin unit nucleosome stalls RNA polymerase II (RNAPII) when it transcribes genetic information on DNA. Using cryo–electron microscopy, Kujirai et al.
T. Kujirai, H. Ehara, Y. Fujino, M. Shirouzu, S. Sekine, H. Kurumizaka   +5 more
semanticscholar   +1 more source

Quantitative Analysis of Single-Molecule Force Spectroscopy on Folded Chromatin Fibers

, 2015
Single-molecule techniques allow for picoNewton manipulation and nanometer accuracy measurements of single chromatin fibers. However, the complexity of the data, the heterogeneity of the composition of individual fibers and the relatively large ...
Andresen, Kurt, Meng, He, Van Noort, John   +2 more
core   +2 more sources

DNA folding: structural and mechanical properties of the two-angle model for chromatin [PDF]

, 2001
We present a theoretical analysis of the structural and mechanical properties of the 30-nm chromatin fiber. Our study is based on the two-angle model introduced by Woodcock et al. (Woodcock, C. L., S. A. Grigoryev, R. A. Horowitz, and N. Whitaker.
Bednar, Bednar, Butler, Cluzel, Crothers, Cui, de Gennes, Doi, Finch, Fraden, Hagerman, Helmut Schiessel, Horowitz, Katritch, Khrapunov, Klenin, Leuba, Livolant, Luger, Marko, Marko, Nyrkova, Plewa, Raspaud, Robijn Bruinsma, Schlick, Smith, Stryer, Thoma, van Holde, van Holde, van Holde, Widom, Widom, Widom, Widom, Widom, William M. Gelbart, Woodcock, Yao   +39 more
core   +3 more sources

Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa

Advanced Science, EarlyView.
Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang, Xiaofei Wang, Chengli Liu, Kaixuan He, Xiu‐Li Hou, Haofei Luo, Shuaibin Zhang, Changqing You, Yajun Jia, Fuqiang Wang, Xianwei Song, Guodao Liu, Xian Deng, Xiaofeng Cao   +13 more
wiley   +1 more source

NUCOME: A comprehensive database of nucleosome organization referenced landscapes in mammalian genomes

BMC Bioinformatics, 2021
Background Nucleosome organization is involved in many regulatory activities in various organisms. However, studies integrating nucleosome organization in mammalian genomes are very limited mainly due to the lack of comprehensive data quality control (QC)
Xiaolan Chen, Hui Yang, Guifen Liu, Yong Zhang   +3 more
doaj   +1 more source