Results 11 to 20 of about 156,001 (374)
Proceedings of the National Academy of Sciences, 1997 Archaeacontain histones that have primary sequences in common with eukaryal nucleosome core histones and a three-dimensional structure that is essentially only the histone fold. Here we report the results of experiments that document that archaeal histones compact DNAin vivointo structures similar to the structure formed by the histone (H3+H4)2tetramer
S L, Pereira +3 more
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Nucleosome Organization in Human Embryonic Stem Cells. [PDF]
PLoS ONE, 2015 The fundamental repeating unit of eukaryotic chromatin is the nucleosome. Besides being involved in packaging DNA, nucleosome organization plays an important role in transcriptional regulation and cellular identity.
Puya G Yazdi +7 more
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NucleoMap: A computational tool for identifying nucleosomes in ultra-high resolution contact maps.
PLoS Computational Biology, 2022 Although poorly positioned nucleosomes are ubiquitous in the eukaryotic genome, they are difficult to identify with existing nucleosome identification methods.
Yuanhao Huang, Bingjiang Wang, Jie Liu
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Physical Review Letters, 2008 We present a statistical-mechanical model for the positioning of nucleosomes along genomic DNA molecules as a function of the strength of the binding potential and the chemical potential of the nucleosomes. We show that a significant section of the DNA is composed of two-level nucleosome switching regions where the nucleosome distribution undergoes a ...
David J, Schwab +3 more
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The effect of micrococcal nuclease digestion on nucleosome positioning data. [PDF]
PLoS ONE, 2010 Eukaryotic genomes are packed into chromatin, whose basic repeating unit is the nucleosome. Nucleosome positioning is a widely researched area. A common experimental procedure to determine nucleosome positions involves the use of micrococcal nuclease ...
Ho-Ryun Chung +7 more
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The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes. [PDF]
, 2009 Evenly spaced nucleosomes directly correlate with condensed chromatin and gene silencing. The ATP-dependent chromatin assembly factor (ACF) forms such structures in vitro and is required for silencing in vivo.
Acevedo, Ashley +8 more
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Genome Biology, 2021 We develop a novel computational method, NucHMM, to identify functional nucleosome states associated with cell type-specific combinatorial histone marks and nucleosome organization features such as phasing, spacing and positioning. We test it on publicly
Kun Fang +3 more
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Science Advances, 2015 Reestablishment of the nucleosome landscape behind the replication fork is fundamental for epigenetic memory during development.
Ramachandran, Srinivas, Henikoff, Steven
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Inter-nucleosomal potentials from nucleosomal positioning data
The European Physical Journal E, 2022 AbstractNo systematic method exists to derive inter-nucleosomal potentials between nucleosomes along a chromosome consistently across a given genome. Such potentials can yield information on nucleosomal ordering, thermal as well as mechanical properties of chromosomes.
Kunhe Li +3 more
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Biochemical characterization of the placeholder nucleosome for DNA hypomethylation maintenance
Biochemistry and Biophysics Reports, 2019 DNA methylation functions as a prominent epigenetic mark, and its patterns are transmitted to the genomes of offspring. The nucleosome containing the histone H2A.Z variant and histone H3K4 mono-methylation acts as a “placeholder” nucleosome for DNA ...
Rina Hirano +3 more
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