Results 11 to 20 of about 64,059 (299)
Genome Biology, 2021 We develop a novel computational method, NucHMM, to identify functional nucleosome states associated with cell type-specific combinatorial histone marks and nucleosome organization features such as phasing, spacing and positioning. We test it on publicly
Kun Fang +3 more
doaj +1 more source
Nucleosome sliding can influence the spreading of histone modifications [PDF]
, 2021 Nucleosomes are the fundamental building blocks of chromatin that not only help in the folding of chromatin but also in carrying epigenetic information. It is known that nucleosome sliding is responsible for dynamically organizing chromatin structure and the resulting gene regulation.
arxiv +1 more source
A systematic analysis of nucleosome core particle and nucleosome-nucleosome stacking structure [PDF]
Scientific Reports, 2018 AbstractChromatin condensation is driven by the energetically favourable interaction between nucleosome core particles (NCPs). The close NCP-NCP contact, stacking, is a primary structural element of all condensed states of chromatin in vitro and in vivo.
Korolev, Nikolay +2 more
openaire +5 more sources
RNAlater facilitates remote sampling of aquaculture Atlantic salmon liver for proteomic analysis
Aquaculture, Fish and Fisheries, Volume 2, Issue 6, Page 578-586, December 2022., 2022 Graphical Abstract Proteomes of similar sizes were obtained in samples preserved by snap‐freezing or RNAlater. Proteins involved in transcriptional and translational machinery were affected in RNAlater stored samples. Abundance of published markers for heat and oxidative stress was not affected by snap‐freezing or RNAlater.
Anca G. Rusu +6 more
wiley +1 more source
Structural and biochemical analyses of monoubiquitinated human histones H2B and H4 [PDF]
Open Biology, 2016 Monoubiquitination is a major histone post-translational modification. In humans, the histone H2B K120 and histone H4 K31 residues are monoubiquitinated and may form transcriptionally active chromatin.
Shinichi Machida +4 more
doaj +1 more source
Circulating Nucleosomes and Nucleosome Modifications as Biomarkers in Cancer [PDF]
Cancers, 2017 Traditionally the stratification of many cancers involves combining tumour and clinicopathological features (e.g., patient age; tumour size, grade, receptor status and location) to inform treatment options and predict recurrence risk and survival. However, current biomarkers often require invasive excision of the tumour for profiling, do not allow ...
Peter McAnena +2 more
openaire +2 more sources
Contributions of histone H3 nucleosome core surface mutations to chromatin structures, silencing and DNA repair. [PDF]
PLoS ONE, 2011 Histone H3 mutations in residues that cluster in a discrete region on the nucleosome surface around lysine 79 of H3 affect H3-K79 methylation, impair transcriptional silencing in subtelomeric chromatin, and reveal distinct contributions of histone H3 to ...
Michel Fink +2 more
doaj +1 more source
Nucleosome Positioning, Nucleosome Spacing and the Nucleosome Code [PDF]
Journal of Biomolecular Structure and Dynamics, 2010 Nucleosome positioning has been the subject of intense study for many years. The properties of micrococcal nuclease, the enzyme central to these studies, are discussed. The various methods used to determine nucleosome positions in vitro and in vivo are reviewed critically.
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Nucleosome—nucleosome interaction in chromatin
FEBS Letters, 1979 The available data suggest that transcriptional activity of chromatin is connected with its structural changes [ 1,2]. According to the electron microscope evidence, the elementary 100 A chromatin thread can exist in two main states, i.e., in a compact state, which is characterized by tight packing of nucleosomes and in an extended state when the ...
S. B. Svetlikova +2 more
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Science Advances, 2015 Reestablishment of the nucleosome landscape behind the replication fork is fundamental for epigenetic memory during development.
Ramachandran, Srinivas, Henikoff, Steven
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