Results 51 to 60 of about 141,257 (371)
Linking stochastic fluctuations in chromatin structure and gene expression. [PDF]
PLoS Biology, 2013 The number of mRNA and protein molecules expressed from a single gene molecule fluctuates over time. These fluctuations have been attributed, in part, to the random transitioning of promoters between transcriptionally active and inactive states, causing ...
Christopher R Brown +4 more
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Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding
Nucleic Acids Research, 2020 Nuclear proteins bind chromatin to execute and regulate genome-templated processes. While studies of individual nucleosome interactions have suggested that an acidic patch on the nucleosome disk may be a common site for recruitment to chromatin, the ...
Aleksandra Skrajna +12 more
semanticscholar +1 more source
FACT, the Bur kinase pathway, and the histone co-repressor HirC have overlapping nucleosome-related roles in yeast transcription elongation. [PDF]
PLoS ONE, 2011 Gene transcription is constrained by the nucleosomal nature of chromosomal DNA. This nucleosomal barrier is modulated by FACT, a conserved histone-binding heterodimer.
Jennifer R Stevens +6 more
doaj +1 more source
ISRN Molecular Biology, 2012 Nucleosome positioning is not only related to genomic DNA compaction but also to other biological functions. After the chromatin is digested by micrococcal nuclease, nucleosomal (nucleosome-bound) DNA fragments can be sequenced and mapped on the genomic DNA sequence.
openaire +2 more sources
Mediator–Nucleosome Interaction [PDF]
Molecular Cell, 2000 Mediator, a multiprotein complex involved in the regulation of RNA polymerase II transcription, binds to nucleosomes and acetylates histones. Three lines of evidence identify the Nut1 subunit of Mediator as responsible for the histone acetyltransferase (HAT) activity. An "in-gel" HAT assay reveals a single band of the appropriate size.
Lawrence C. Myers +4 more
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Nucleosome repositioning via loop formation [PDF]
, 2002 Active (catalysed) and passive (intrinsic) nucleosome repositioning is known to be a crucial event during the transcriptional activation of certain eucaryotic genes.
Abramowitz +42 more
core +3 more sources
BMC Genomics, 2010 Background Recently, a number of high-resolution genome-wide maps of nucleosome locations in S. cerevisiae have been derived experimentally. However, nucleosome positions are determined in vivo by the combined effects of numerous factors.
Deng Yangyang +6 more
doaj +1 more source
Nucleosome packaging and nucleosome positioning of genomic DNA [PDF]
Proceedings of the National Academy of Sciences, 1997 The goals of this study were to assess the extent to which bulk genomic DNA sequences contribute to their own packaging in nucleosomes and to reveal the relationship between nucleosome packaging and positioning. Using a competitive nucleosome reconstitution assay, we found that at least 95% of bulk DNA sequences have an affinity for ...
J. Widom, P. T. Lowary
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Conserved substitution patterns around nucleosome footprints in eukaryotes and Archaea derive from frequent nucleosome repositioning through evolution. [PDF]
, 2013 Nucleosomes, the basic repeat units of eukaryotic chromatin, have been suggested to influence the evolution of eukaryotic genomes, both by altering the propensity of DNA to mutate and by selection acting to maintain or exclude nucleosomes in particular ...
Becker, Erin +4 more
core +2 more sources
Control of nucleosome movement: To space or not to space nucleosomes? [PDF]
Epigenetics, 2010 A key feature of ATP-dependent chromatin remodeling complexes is how they control the ability of the complex to translocate along DNA within the context of a nucleosome. Although these complexes generally initiate DNA translocation near the dyad axis of the nucleosome, the progression and eventual termination is regulated in quite distinct ways.
Blaine Bartholomew, Punit Prasad
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