Results 101 to 110 of about 2,433 (185)

Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT

Journal of Translational Medicine, 2020
Background NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity that results in therapeutic failure in pediatric acute lymphoblastic leukemia (ALL).
Yoomi Park, Hyery Kim, Heewon Seo, Jung Yoon Choi, Youngeun Ma, Sunmin Yun, Byung-Joo Min, Myung-Eui Seo, Keon Hee Yoo, Hyoung Jin Kang, Ho Joon Im, Ju Han Kim   +11 more
doaj   +1 more source

Screening of Novel Pharmacogenetic Candidates for Mercaptopurine-Induced Toxicity in Patients With Acute Lymphoblastic Leukemia

Frontiers in Pharmacology, 2020
A small proportion of patients with acute lymphoblastic leukemia (ALL) may experience severe leukopenia after treating with 6-mercaptopurine (6MP), which can be largely explained by germline variants in TPMT and NUDT15.
Minyuan Cao, Minyuan Cao, Dandan Yin, Yun Qin, Fei Liao, Yali Su, Xuyang Xia, Ju Gao, Yiping Zhu, Wei Zhang, Yang Shu, Xiaoxi Lu   +11 more
doaj   +1 more source

Precision Medicine in Inflammatory Bowel Disease [PDF]

, 2019
Background: Individual patient variability may explain why despite a growing number of therapeutic options in the treatment of inflammatory bowel disease (IBD) many patients still suffer from disabling disease.
Walker, G
core  

Pharmacotherapy Risks in Rare Genetic Diseases: Cross‐Referencing ACMG Secondary Findings v3.2 List With Clinical Databases

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT Clinical genomics and pharmacogenomics have largely remained separate fields, though some genetic variants have overlapping disease risk and drug implications. However, the extent of this overlap is not well studied. To explore this gap, we cross‐referenced genes from the American College of Medical Genetics Secondary Findings v3.2 list with ...
Josiah D. Allen, Benjamin Q. Duong, Jordan Brady, Pamela Arn   +3 more
wiley   +1 more source

Personalization of thiopurine therapy: Current recommendations and future perspectives

Acta Pharmaceutica
Despite great therapeutic advances in the field of biologics, small synthetic molecules such as thiopurines, including azathioprine, mercaptopurine, and thioguanine, remain an important therapeutic pillar in the treatment of inflammatory bowel disease ...
Urbančič Dunja, Pasha Flaka, Šmid Alenka, Mlinarič-Raščan Irena   +3 more
doaj   +1 more source

French‐Speaking Network of Pharmacogenetics (RNPGx) Recommendations for Gene Panel Analysis Through Genotyping or Sequencing in Pharmacogenetics

Fundamental &Clinical Pharmacology, Volume 40, Issue 1, January 2026.
ABSTRACT Background The implementation of pharmacogenetics in clinical practice increasingly relies on multigene panels. Objectives The objective of this study is to develop harmonized recommendations for the design and analytical implementation of multigene pharmacogenetic panels, defining clinically relevant genes and associated regions of interest ...
Nicolas Picard, Estelle Ayme‐Dietrich, Sylvie Quaranta, Tiphaine Adam‐De‐Beaumais, Abd El Kader Ait Tayeb, Hugo Alarcan, Dorra Amor, David Barthelemy, Mouna Ben Sassi, Séverine Cunat, Mouna Daldoul, Hervé Delacour, Marie‐Christine Etienne‐Grimaldi, Xavier Fonrose, Benjamin Hennart, Louis Lebreton, Stephanie Malard, Céline Narjoz, Asma Omezzine, Nicolas Pallet, Léa Payen, Jeanne Petit, Fabienne Thomas, Sameh Trabelsi, Camille Tron, Céline Verstuyft, Paul Vilquin, Jean‐Christophe Boyer, Vincent Haufroid, French‐Speaking Network of Pharmacogenetics (RNPGx)   +29 more
wiley   +1 more source

Combining thiopurine with partial enteral nutrition promotes complete mucosal healing in pediatric Crohn's disease

Pediatrics International, Volume 68, Issue 1, January/December 2026.
Abstract Background The combination of thiopurines and partial enteral nutrition (TP/PEN) is a common maintenance therapy for mild‐to‐moderate Crohn's disease (CD) in pediatric patients. However, no studies have investigated the efficacy of TP/PEN. This study aimed to evaluate the non‐relapse and complete mucosal healing rates in pediatric CD patients ...
Emiri Kaji, Atsushi Yoden, Takahiro Namba, Satomi Nishimoto, Masano Otani, Takeru Okuhira, Keisuke Inoue, Tomoki Aomatsu, Daisuke Nishioka, Akira Ashida   +9 more
wiley   +1 more source

Best practices on immunomodulators and biologic agents for ulcerative colitis and Crohn’s disease in Asia [PDF]

, 2019
The Asia-Pacific Working Group on inflammatory bowel disease (IBD) was established in Cebu, Philippines, under the auspices of the Asian Pacific Association of Gastroenterology with the goal of improving IBD care in Asia. This consensus is carried out in
Abdullah, M, Ahuja, V, Ali, RAR, Banerjee, R, Chen, MH, Chuah, SW, De Silva, JH, Geary, R, Goh, KL, Hilmi, I, Hisamatsu, T, Leong, RWL, Leung, WK, Lim, WC, Limsrivilai, J, Ling, KL, Makharia, GK, Mustaffa, N, Ng, SC, Ong, D, Ong, E, Ooi, CJ, Ouyang, Q, Park, DI, Pisespongsa, P, Ren, ZH, Rerknimitr, R, Simadibrata, M, Sollano, J, Wei, SC, Wu, DC, Yang, SK, Ye, BD   +32 more
core   +1 more source

NUDT15 Polymorphism Confer Increased Susceptibility to Thiopurine-Induced Leukopenia in Patients With Autoimmune Hepatitis and Related Cirrhosis

Frontiers in Pharmacology, 2019
The aim of this study was to investigate the influence of NUDT15 R139C and thiopurine S-methyltransferase (TPMT) on azathioprine (AZA) induced leukopenia in patients with autoimmune hepatitis (AIH) and related cirrhosis.
Xiaoli Fan, Dandan Yin, Ruoting Men, Heng Xu, Li Yang   +4 more
doaj   +1 more source

PHARMACOGENOMICS IN THE EMIRATI POPULATION: APPLICATIONS IN CARDIOVASCULAR DISEASES AND ONCOLOGY [PDF]

, 2020
Pharmacogenetic variations contribute to interindividual differences in drug response. Advances in molecular techniques provided insights into interpopulation pharmacogenomic variations.
Al Mahairi, Zeina Nizar
core   +1 more source