Results 161 to 170 of about 2,433 (185)

Landscape of TPMT and NUDT15 Pharmacogenetic Variation in a Cohort of Canadian Pediatric Inflammatory Bowel Disease Patients. [PDF]

Inflamm Bowel Dis
Kennedy AM, Griffiths AM, Muise AM, Walters TD, Ricciuto A, Huynh HQ, Wine E, Jacobson K, Lawrence S, Carman N, Mack DR, deBruyn JC, Otley AR, Deslandres C, El-Matary W, Zachos M, Benchimol EI, Critch J, Schneider R, Crowley E, Li M, Warner N, McGovern DPB, Li D, Haritunians T, Rudin S, Cohn I.   +26 more
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Clinical Pharmacogenetics: Results After Implementation of Preemptive Tests in Daily Routine. [PDF]

J Pers Med
Díaz-Villamarín X, Martínez-Pérez M, Nieto-Sánchez MT, Fernández-Varón E, Torres-García A, Blancas I, Cabeza-Barrera J, Morón R.   +7 more
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Implementing Pre-Emptive Pharmacogenetics: Impact of Early Pharmacogenetic Screening in a Pediatric Oncology Cohort of 1,151 Subjects. [PDF]

Clin Pharmacol Ther
Bernsen EC, Verwiel ETP, van der Lee M, Swen JJ, Santoso M, Brigitha LJ, Admiraal R, Tops BBJ, Huitema ADR, Kemmeren P, Hehir-Kwa JY, Hanff LM, Diekstra MHM.   +12 more
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Therapeutic Agents and Patient Characteristics Affecting Metabolism of Thiopurines in Patients with Inflammatory Bowel Disease. [PDF]

Fukushima J Med Sci
Aizawa M, Suzuki K, Nakajima Y, Utano K, Tamazawa K, Ueda K, Wada J, Sato K, Shibukawa G, Tanaka N, Togashi K.   +10 more
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Targeted Protein Degradation of NUDT5 Reveals an Unexpected Non-Enzymatic Role in 6-Thioguanine-Mediated Toxicity

Marques AMC, Bauer LG, Nguyen T, Orta AG, Venne J, Cheng L, Balikci E, Tivon B, London N, Kubicek S, Huber KVM.   +10 more
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Low NUDT15 expression levels due to biallelic NUDT15 variants and 6‐mercaptopurine intolerance

British Journal of Haematology, 2022
Summary6‐Mercaptopurine (6‐MP) is widely used for the treatment of paediatric leukaemia and lymphoma. Recently, germline variants in the NUDT15 gene have been identified as one of the major genetic causes for 6‐MP–associated adverse effects such as myelosuppression.
Masanori Yoshida, Scott A. Brown, Takaya Moriyama, Rina Nishii, Shin‐ichi Tsujimoto, Yuji Yamada, Kaoru Yoshida, Ryota Shirai, Tomoo Osumi, Tomoyuki Utano, Reiji Fukano, Ko Kudo, Kimiyoshi Sakaguchi, Yuki Arakawa, Katsuyoshi Koh, Masahiro Sekiguchi, Masahiro Sekimizu, Takako Miyamura, Hisashi Ishida, Takeshi Inukai, Daisuke Tomizawa, Nobutaka Kiyokawa, Motohiro Kato, Jun J. Yang   +23 more
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NUDT15: A bench to bedside success story

Clinical Biochemistry, 2021
Recently, the enzyme nudix hydrolase 15 (NUDT15) has been identified as an additional component of the thiopurine metabolism pathway. NUDT15 (also known as MTH2) catalyzes the dephosphorylation of 6-thioguanosine triphosphate (6-TGTP) and 6-thio-deoxyguanosine triphosphate (6-TdGTP), which is the active metabolite of thiopurine medications.
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NUDT15 genotype distributions in the Korean population

Pharmacogenetics and Genomics, 2017
Thiopurines have a narrow therapeutic range because of frequent toxicity (i.e. marrow suppression), which is only partly explained by TPMT genetic polymorphisms, especially within Asian populations. Recent studies have identified NUDT15 variation as another important factor affecting thiopurine metabolism.
Hyoung-Tae, Kim, Rihwa, Choi, Hong-Hee, Won, Yon Ho, Choe, Ben, Kang, Kiwuk, Lee, Hong Hoe, Koo, Keon Hee, Yoo, Young-Ho, Kim, Soo-Youn, Lee   +9 more
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Cost-effectiveness analysis of pretreatment screening for NUDT15 defective alleles

Pharmacogenetics and Genomics, 2020
Background Nucleotide triphosphate diphosphatase (NUDT15) genetic testing in addition to thiopurine methyl transferase (TPMT) is recommended to reduce the incidence of adverse severe myelotoxicity episodes induced by thiopurines. Objective We assessed the cost-effectiveness ratio of
Kevin, Zarca, Albain, Chansavang, Marie-Anne, Loriot, Isabelle, Durand-Zaleski, Nicolas, Pallet   +4 more
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Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15 variants

Pediatric Research, 2020
Mercaptopurine-induced neutropenia can interrupt chemotherapy and expose patients to infection during childhood acute lymphoblastic leukemia (ALL) treatment. Previously, six candidate gene variants associated with mercaptopurine intolerance were reported.
Der-Shiun, Wang, Chih-Hsiang, Yu, Chien-Yu, Lin, Ya-Hsuan, Chang, Kai-Hsin, Lin, Dong-Tsamn, Lin, Shiann-Tarng, Jou, Meng-Yao, Lu, Hsiu-Hao, Chang, Shu-Wha, Lin, Hsuan-Yu, Chen, Yung-Li, Yang   +11 more
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