Results 31 to 40 of about 2,433 (185)
Frontiers in Pharmacology, 2021 The aim of this study was to investigate the correlation between genetic polymorphisms of azathioprine-metabolizing enzymes and adverse reactions of myelosuppression. To this end, a retrospective analysis was performed on 1,419 Chinese patients involving
Zhao-Yang Chen +16 more
doaj +1 more source
Clinical and Economic Impact of Expanded TPMT Testing to Prevent Thiopurine-Induced Myelosuppression in Australia: A Budget Impact Analysis. [PDF]
Clin Transl SciABSTRACT Testing thiopurine methyltransferase (TPMT) enzyme activity or genotype prior to thiopurine prescribing is recommended to reduce the risk of moderate to severe—and potentially fatal—myelosuppression in poor or intermediate TPMT metabolizers. Despite this, only about one‐third of individuals prescribed thiopurines in Australia currently receive
Ianni BD +4 more
europepmc +2 more sources
Massively parallel variant characterization identifiesNUDT15alleles associated with thiopurine toxicity [PDF]
Proceedings of the National Academy of Sciences, 2020 SignificancePharmacogenetics is a prototype of genomics-guided precision medicine. While there is a rapid expansion of novel pharmacogenetic variants discovered by genome sequencing, the lack of variant interpretation in a scalable fashion is a formidable barrier in this field.NUDT15polymorphism is a major genetic cause for hematopoietic toxicity ...
Chase C. Suiter +31 more
openaire +5 more sources
Journal of Genetic Engineering and Biotechnology, 2023 Background Human nucleotide triphosphate diphosphatase (NUDT15) is one of the essential proteins involved in the hydrolysis of anti-cancer drugs against leukemia.
Janakiraman V. +5 more
doaj +1 more source
NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity [PDF]
Nature Genetics, 2016 Widely used as anticancer and immunosuppressive agents, thiopurines have narrow therapeutic indices owing to frequent toxicities, partly explained by TPMT genetic polymorphisms. Recent studies identified germline NUDT15 variation as another critical determinant of thiopurine intolerance, but the underlying molecular mechanisms and the clinical ...
Takaya Moriyama +33 more
openaire +3 more sources
Long-term efficacy and tolerability of dose-adjusted thiopurine treatment in maintaining remission in inflammatory bowel disease patients with NUDT15 heterozygosity [PDF]
, 2021 弘前大学博士（医学）掲載誌：Intestinal research, 2020.00133, 2021doctoral ...
前田, 高人
core +1 more source
Mammalian Nudt15 hydrolytic and binding activity on methylated guanosine mononucleotides
European Biophysics Journal, 2023 AbstractThe Nudt15 enzyme of the NUDIX protein family is the subject of extensive study due to its action on thiopurine drugs used in the treatment of cancer and inflammatory diseases. In addition to thiopurines, Nudt15 is enzymatically active in vitro on several nucleotide substrates.
Maciej Lukaszewicz +6 more
openaire +2 more sources
Pharmacogenomic tests in Oncology - finding the right dose
Brazilian Journal of Oncology, 2021 A pharmacogenetics/genomics (PGx) anticancer drug testing program is being developed by Kurtz and his group at the Brazilian National Cancer Institute (INCA).
Jeziel Basso, Gilberto Schwartsmann
doaj +1 more source
Frontiers in Pediatrics, 2021 Background: 6-Mercaptopurine (6-MP) is the cornerstone of current antileukemia regimen and contributes greatly to improve the survival of pediatric acute lymphoblastic leukemia (ALL) patients.
Xiaoyan Mao +11 more
doaj +1 more source
Supervised learning of protein variant effects across large-scale mutagenesis datasets. [PDF]
Protein SciAbstract The increasing availability of data from multiplexed assays of variant effects (MAVEs) enables supervised model training against large quantities of experimental data to learn sequence‐function relationships. Variant effect scores from MAVEs can, however, be influenced by the experimental method and library composition, resulting in experiment‐
Schulze TK +3 more
europepmc +2 more sources