Results 51 to 60 of about 2,433 (185)
Second Korean guidelines for the management of ulcerative colitis [PDF]
, 2017 Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by a relapsing and remitting course. The direct and indirect costs of the treatment of UC are high, and the quality of life of patients is reduced, especially during ...
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Use of thiopurines in inflammatory bowel disease : an update [PDF]
, 2021 Inflammatory bowel disease (IBD), once considered a disease of the Western hemisphere, has emerged as a global disease. As the disease prevalence is on a steady rise, management of IBD has come under the spotlight.
Ahuja, Vineet +25 more
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A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia [PDF]
Nature Genetics, 2014 Thiopurine therapy, commonly used in autoimmune conditions, can be complicated by life-threatening leukopenia. This leukopenia is associated with genetic variation in TPMT (encoding thiopurine S-methyltransferase). Despite a lower frequency of TPMT mutations in Asians, the incidence of thiopurine-induced leukopenia is higher in Asians than in ...
Suk-Kyun, Yang +16 more
openaire +2 more sources
Children, 2021 Mercaptopurine (MP) is a commonly used maintenance regimen for childhood acute lymphoblastic leukemia (ALL). However, 6-MP has a narrow therapeutic index, which causes dose-limiting toxicities in hematopoietic tissues.
Jae Min Lee +4 more
doaj +1 more source
NUDT15 변이 유전자형을 가진 급성림프모구백혈병 환자에서 치료 표지자로서 DNA-치오구아닌 뉴클레오티드의 이용 [PDF]
, 2021 학위논문 (박사) -- 서울대학교 대학원 : 의과대학 의학과, 2021. 2. 신희영.Background Large inter-individual variations in drug metabolism pose a challenge in determining 6-mercaptopurine (6MP) doses.
주희영
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Etiology and risk factors of febrile neutropenia in children during cancer treatment [PDF]
, 2020 Side effects due to chemotherapy is still a major issue during cancer treatment. Febrile neutropenia and associated microbiological defined infections (MDIs) are dreaded complications, and still a cause of death during pediatric cancer treatment.
Wahlund, Martina
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Implementation of CYP2D6 copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder [PDF]
, 2022 We demonstrate that CYP2D6 copy-number variation (CNV) can be imputed using existing imputation algorithms. Additionally, we report frequencies of key pharmacogenetic variants in individuals with a psychotic disorder from the genetically bottle-necked ...
Ahola-Olli, Ari V. +26 more
core +6 more sources
PLoS ONE, 2021 BackgroundLarge inter-individual variations in drug metabolism pose a challenge in determining 6-mercaptopurine (6MP) doses. As the last product of 6MP metabolism, DNA-thioguanine nucleotide (DNA-TGN) could reflect the efficacy of 6MP, especially in ...
Hee Young Ju +10 more
doaj +1 more source
Pharmacogenomic tests of oncology drugs at Instituto Nacional de Câncer (INCA)
Brazilian Journal of Oncology, 2021 The implementation, current status and future perspectives of the pharmacogenetics/genomics (PGx) testing program developed at Instituto Nacional de Cancer (INCA) are presented. Initial selection of drug-gene pairs for PGx testing was based on clinically-
Guilherme Suarez-Kurtz
doaj +1 more source
Mercaptopurine induced myelosuppression in a child with a NUDT15 rs116855232 homozygous variant
Journal of Oncology Pharmacy Practice, 2022 Introduction Mercaptopurine (6-MP) is the backbone of the consolidation and maintenance therapy for paediatric acute lymphoblastic leukaemia (ALL). Nevertheless, it can cause critical myelosuppression. Predicting adverse reactions to 6-MP often involves the investigation of pharmacogenetic variants; in particular thiopurine S-methyltransferase ( TPMT ...
Navya Gupta +5 more
openaire +5 more sources