Results 61 to 70 of about 2,433 (185)

TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India

BMC Gastroenterology, 2021
Background Polymorphisms in thiopurine methyltransferase (TPMT) and Nudix hydrolase-15 (NUDT15) have been implicated as the predominant cause of thiopurine induced leukopenia in the Western countries and East Asia respectively.
Narinder Grover, Prateek Bhatia, Antriksh Kumar, Minu Singh, Deepesh Lad, Harshal S. Mandavdhare, Jayanta Samanta, Kaushal K. Prasad, Usha Dutta, Vishal Sharma   +9 more
doaj   +1 more source

Predicted efficacy of a pharmacogenetic passport for inflammatory bowel disease [PDF]

, 2020
BACKGROUND: High inter-individual variability in therapeutic response to drugs used in the management of Inflammatory Bowel Disease (IBD) leads to high morbidity and high costs.
Auton, Chaparro, Coenen, Feuerstein, Flamant, Gallagher, Gearry, Gisbert, Gomollon, Graaff, Heap, Ledder, Lennard, Loh, McKenna, Mogilevski, Moon, Moriyama, Mowat, Price, Relling, Relling, Sazonovs, Schouwenburg, Tonk, Torres, Ungaro, Valk, Vande Casteele, Vermeire, Wadhwa, Walker, Whirl-Carrillo, Wilson, Wolbink   +34 more
core   +1 more source

Comparison of variants in TPMT and NUDT15 between sequencing and genotyping methods in a multistate pediatric institution

Clinical and Translational Science, 2023
The risk of severe adverse events related to thiopurine therapy can be reduced by personalizing dosing based on TPMT and NUDT15 genetic polymorphisms. However, the optimal genetic testing platform has not yet been established. In this study, we report on
Kelsey J. Cook, Victoria Grusauskas, Lucy Gloe, Benjamin Q. Duong, Renee C. Gresh, E. Anders Kolb, Manisha Bansal, Allison S. Bechtel, Ramamoorthy Nagasubramanian, Susan M. Kirwin, Kathryn V. Blake, Nathan D. Seligson   +11 more
doaj   +1 more source

Decoding genetic divergence: TPMT and NUDT15 polymorphisms in north India mirror Caucasian ancestry. [PDF]

Intest Res
Singh A, Pandita RM, Goyal MK, Dhillon BK, Midha V, Sood A.   +5 more
europepmc   +3 more sources

Association of NUDT15*3 and FPGS 2572C>

Genes, 2020
Genetic variants influencing the pharmacokinetics and/or pharmacodynamics of the chemotherapeutic drugs used in Acute Lymphoblastic Leukemia (ALL) therapy often contribute to the occurrence of treatment related toxicity (TRT). In this study, we explored the association of candidate genetic variants with early hematological TRT (grade 3 ...
Kodidela, Sunitha, Dorababu, Patchava, Thakkar, Dimpal N, Dubashi, Biswajit, Sundaram, Rajan, Muralidharan, Niveditha, Nidanapu, Ravi Prasad, Aribandi, Anil, Pradhan, Suresh Chandra, Uppugunduri, Chakradhara Rao Satyanarayana   +9 more
openaire   +1 more source

NUDT15, FTO, and RUNX1 genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases

Intestinal Research, 2017
Background/Aims: Recent genome-wide analyses have provided strong evidence concerning adverse events caused by thiopurine drugs such as azathioprine (AZA) and 6-mercaptopurine.
Toshiyuki Sato, Tetsuya Takagawa, Yoichi Kakuta, Akihiro Nishio, Mikio Kawai, Koji Kamikozuru, Yoko Yokoyama, Yuko Kita, Takako Miyazaki, Masaki Iimuro, Nobuyuki Hida, Kazutoshi Hori, Hiroki Ikeuchi, Shiro Nakamura   +13 more
doaj   +1 more source

Impact of mercaptopurine metabolites on disease outcome in the AIEOP-BFM 2009 protocol for acute lymphoblastic leukemia [PDF]

, 2023
: In the maintenance phase of AIEOP-BFM acute lymphoblastic leukemia (ALL) 2009 protocol, mercaptopurine (MP) is given at the planned dose of 50 mg/m2/day; however, dose adjustments are routinely performed to target patients' white blood cells to the ...
Bertorello, Nicoletta, Bettini, Laura Rachele, Colombini, Antonella, Decorti, Giuliana, Fagioli, Franca, Franca, Raffaella, Girardi, Katia, Kiren, Valentina, Locatelli, Franco, Quarello, Paola, Rabusin, Marco, Rizzari, Carmelo, Silvestri, Daniela, Stocco, Gabriele, Tessitore, Antimo, Valsecchi, Maria Grazia, Vinti, Luciana   +16 more
core   +1 more source

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

The frequency of NUDT15 rs116855232 and its impact on mercaptopurine-induced toxicity in Syrian children with acute lymphoblastic leukemia

Frontiers in Oncology
IntroductionPolymorphisms in NUDT15 may result in differences in mercaptopurine-induced toxicity. This study aimed to identify the frequency of the NUDT15 (c.415C>T; rs116855232) polymorphism and investigate the effect of this polymorphism on ...
Muhammad Muhammad, Muhammad Muhammad, Maher Saifo, Maher Saifo, Majd Aljamali, Majd Aljamali, Mousa Alali, Khaled M. Ghanem   +7 more
doaj   +1 more source

Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?

BMC Cancer, 2018
Background 6-mercaptopurine (6-MP) contributes substantially to remarkable improvement in the survival of childhood acute lymphoblastic leukemia (ALL) patients.
Hong Zhou, Lei Li, Peng Yang, Lin Yang, Jin E. Zheng, Ying Zhou, Yong Han   +6 more
doaj   +1 more source