Results 121 to 130 of about 4,448 (184)

Rescuable sleep and synaptogenesis phenotypes in a Drosophila model of O-GlcNAc transferase intellectual disability

eLife
O-GlcNAcylation is an essential intracellular protein modification mediated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Recently, missense mutations in OGT have been linked to intellectual disability, indicating that this modification is ...
Ignacy Czajewski, Bijayalaxmi Swain, Jiawei Xu, Laurin McDowall, Andrew T Ferenbach, Daan MF van Aalten   +5 more
doaj   +1 more source

Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma

Biomolecules
Post-translational modifications (PTMs) influence protein functionality by modulating protein stability, localization, and interactions with other molecules, thereby controlling various cellular processes. Common PTMs include phosphorylation, acetylation,
Xinyu Zhou, Sirui Hang, Qingqing Wang, Liu Xu, Peter Wang   +4 more
doaj   +1 more source

O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies. [PDF]

ACS Chem Neurosci, 2022
Permanne B, Sand A, Ousson S, Nény M, Hantson J, Schubert R, Wiessner C, Quattropani A, Beher D.   +8 more
europepmc   +1 more source

Benzo[d]thiazol-5-yl Compounds as O-GlcNAcase Inhibitors for Treating Alzheimer's Disease. [PDF]

ACS Med Chem Lett, 2021
Sabnis RW.
europepmc   +1 more source

Epidermal growth factor receptors: function modulation by phosphorylation and glycosylation interplay [PDF]

, 2018
Post-translational modifications (PTMs) of proteins induce structural and functional changes that are most often transitory and difficult to follow and investigate invivo.
Ahmad, Ishtiaq, Hoessli, Daniel, Kaleem, Afshan, Nasir-ud-Din,,, Saleem, Muhammad, Shakoori, Abdul, Walker-Nasir, Evelyne   +6 more
core  

Protocol for quantification of UDP-GlcNAc using an enzymatic microplate assay

STAR Protocols
Summary: Uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) is the end product of the hexosamine biosynthetic pathway and the substrate for protein O-linked N-acetylglucosaminylation (O-GlcNAcylation). Here, we present a protocol for the quantification
Divya Upadhyay, Rishi Banerjee, Jukka Kallijärvi, Janne Purhonen   +3 more
doaj   +1 more source

Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase. [PDF]

Nat Chem Biol, 2021
Ge Y, Ramirez DH, Yang B, D'Souza AK, Aonbangkhen C, Wong S, Woo CM.   +6 more
europepmc   +1 more source

La click-chemistry en el descubrimiento de fármacos [PDF]

, 2016
La revisión bibliográfica que se presenta a continuación trata sobre la llamada clickchemistry y su aplicación en el descubrimiento de fármacos. Para ello se parte de la definición de click-chemistry y sus principales características que la hacen ...
González Vázquez, María
core  

Biological Functions and Potential Therapeutic Significance of O-GlcNAcylation in Hepatic Cellular Stress and Liver Diseases

Cells
O-linked-β-D-N-acetylglucosamine (O-GlcNAc) glycosylation (O-GlcNAcylation), which is dynamically regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), is a post-translational modification involved in multiple cellular processes. O-GlcNAcylation
Zun Mao, Junpeng Mu, Zhixiang Gao, Shile Huang, Long Chen   +4 more
doaj   +1 more source

Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice. [PDF]

Gut, 2021
He X, Gao J, Peng L, Hu T, Wan Y, Zhou M, Zhen P, Cao H.   +7 more
europepmc   +1 more source