A moonlighting metabolic protein influences repair at DNA double-stranded breaks. [PDF]
, 2015 Catalytically active proteins with divergent dual functions are often described as 'moonlighting'. In this work we characterize a new, chromatin-based function of Lys20, a moonlighting protein that is well known for its role in metabolism.
Aris, John P +2 more
core +1 more source
Robust effect of metabolic syndrome on major metabolic pathways in the myocardium.
PLoS ONE, 2019 Although the high-fat-diet-induced metabolic syndrome (MetS) is a precursor of human cardiac pathology, the myocardial metabolic state in MetS is far from clear.
Maryam Karimi +12 more
doaj +1 more source
Glycosylation in the thyroid gland : vital aspects of glycoprotein function in thyrocyte physiology and thyroid disorders [PDF]
, 2018 The key proteins responsible for hormone synthesis in the thyroid are glycosylated. Oligosaccharides strongly affect the function of glycosylated proteins.
Ewa Pocheć +2 more
core +1 more source
Dual functionality of O-GlcNAc transferase is required for Drosophila development [PDF]
, 2015 Post-translational modification of intracellular proteins with O-linked N-acetylglucosamine (O-GlcNAc) catalysed by O-GlcNAc transferase (OGT) has been linked to regulation of diverse cellular functions.
Ferenbach, Andrew T. +6 more
core +2 more sources
Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin. [PDF]
, 2018 The extracellular matrix is a master regulator of tissue homeostasis in health and disease. Here we examined how the small, leucine-rich, extracellular matrix proteoglycan decorin regulates cardiomyocyte metabolism during fasting in vivo.
Gubbiotti, Maria A. +4 more
core +1 more source
Diaminocyclopentane – L-Lysine Adducts: Potent and Selective Inhibitors of Human O-Glcnacase
Bioorganic ChemistryA new class of compounds, namely highly substituted diaminocyclopentane-l-lysine adducts, have been discovered as potent inhibitors of O-GlcNAcase, an enzyme crucial for protein de-O-glycosylation. These inhibitors exhibit exceptional selectivity and reversibility and are the first example of human O-GlcNAcase inhibitors that are structurally related ...
Weber, P. +7 more
openaire +3 more sources
O-GlcNAc Modification During Pregnancy: Focus on Placental Environment
Frontiers in Physiology, 2018 Successful placentation is a key event for fetal development, which commences following embryo implantation into the uterine wall, eliciting decidualization, placentation, and remodeling of blood vessels to provide physiological exchange between embryo ...
Victor Vitorino Lima +7 more
doaj +1 more source
Generation and Characterization of a Stable Inducible O‐GlcNAcase Cell Line
The FASEB Journal, 2015 O‐linked‐β‐N‐acetylglucosamine (O‐GlcNAc) is a dynamic post‐translational modification that is added and removed from nuclear, cytoplasmic, and mitochondrial proteins by the O‐GlcNAc transferase (OGT) and the O‐GlcNAcase (OGA), respectively.
Austin Maduka +2 more
openaire +1 more source
Structural and functional insight into human O-GlcNAcase [PDF]
Acta Crystallographica Section A Foundations and Advances, 2018 Christian Roth +7 more
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Synthesis, -GlcNAc Modification, and Potential Applications of -Acetylglucosamine Derivatives
Natural Product CommunicationsN-acetylglucosamine (GlcNAc) is a versatile monosaccharide with broad applications in medicine, food, and cosmetics due to its antimicrobial, antioxidant, and anti-tumor properties. Efficient synthesis methods for GlcNAc remain a prominent research focus.
Boyuan Wang +8 more
doaj +1 more source