Results 91 to 100 of about 4,448 (184)

Hypoxia‐Induced circPRELID2 Promotes Gastric Cancer Metastasis by Facilitating ZEB2 Translation via PCBP1 O‐GlcNAcylation

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Under hypoxia, HIF1A is directly bound to the PRELID2 promoter to increase PRELID2 pre‐mRNA expression, followed by the DYRK1A–SFPQ–SAM68 complex binding to Alu‐containing introns in PRELID2 pre‐mRNA, leading to circPRELID2 circularization. CircPRELID2 interacts with PCBP1 and promotes its cytoplasmic retention.
Pengshan Zhang, Zai Luo, Yitian Xu, Yuan Zhang, Renchao Zhang, Nadina Paerhati, Shaopeng Zhang, Qianqian Cai, Zhengjun Qiu, Chen Huang   +9 more
wiley   +1 more source

Role of N-glycosylation in renal betaine transport [PDF]

, 2015
The osmolyte and folding chaperone betaine is transported by the renal Na+-coupled GABA (γ-aminobutyric acid) symporter BGT-1 (betaine/GABA transporter 1), a member of the SLC6 (solute carrier 6) family.
Burckhardt, Birgitta C., Fenollar-Ferrer, Cristina, Forrest, Lucy R., Joos, Friedericke, Kempson, Stephen A., Schweikhard, Eva S., Ziegler, Christine   +6 more
core   +1 more source

Recent Advances of In Situ Anticancer Nanomedicine from Enzyme‐Instructed Self‐Assembly

ChemNanoMat, Volume 11, Issue 12, December 2025.
This review summarizes advances in enzymatic self‐assemblies for generating in situ anticancer nanomedicine over the past five years. It highlights the unique features of enzyme substrates for in situ anticancer nanomedicine by discussing the representative examples.
Linrui Zou, Meihui Yi, Bing Xu
wiley   +1 more source

Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability [PDF]

, 2019
O-GlcNAc transferase (OGT) is an X-linked gene product that is essential for normal development of the vertebrate embryo. It catalyses the O-GlcNAc posttranslational modification of nucleocytoplasmic proteins and proteolytic maturation of the ...
Allen, Andrew T. Ferenbach, Ariane C. Wilmes, Daan M. F. van Aalten, Dai, Das, Fourneau, Gundogdu, Han, Hwang, Koufaris, Marios P. Stavridis, Mehmet Gundogdu, Miura, Neri, Peng, Poonam S. Kakade, Shelagh Joss, Stevenson, Sui, Vasudha Vandadi, Veronica M. Pravata, Villo Muha, Vladimir S. Borodkin   +23 more
core   +2 more sources

Protein O‐GlcNAcylation in Health and Diseases

MedComm, Volume 6, Issue 12, December 2025.
We first introduced the beneficial effects of normal protein O‐GlcNAcylation on health, impacting biological processes such as gene expression, cell cycle progression, metabolism, and signal transduction. Next, we described the role of abnormal protein O‐GlcNAcylation in the development and progression of diseases, including neurodegenerative diseases,
Zhihong Ran, Chuanbao Chen, Jingfeng Ou, Guanyi Wu, Chao Yang, Xiaoyou Liu   +5 more
wiley   +1 more source

Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human : O-GlcNAcase [PDF]

, 2016
The modification of nucleocytoplasmic proteins with O-linked N-Acetylglucosamine (O-GlcNAc) plays diverse roles in multicellular organisms. Inhibitors of O-GlcNAc hydrolase (OGA), the enzyme that removes O-GlcNAc from proteins, lead to increased O-GlcNAc
Avalos Gonzalez, Bartlett, Beer, Borghgraef, Cetinbas, Copeland, Dennis, Dorfmueller, Dorfmueller, Dorfmueller, Ferrer, Gao, Graham, Greig, Haltiwanger, Hart, Khidekel, Kim, Kim, Kreppel, Kuntz, Kuzmic, Liu, Liu, Lombard, Lubas, Ma, Macauley, Macauley, Macauley, Macauley, Macauley, Mader, Mark, Mehdy, Morrison, Mosi, Murphy, Ortiz-Meoz, Ozcan, Perrin, Ranuncolo, Rao, Roeser, Ruan, Stubbs, Torres, Trinidad, Wang, Whelan, Whitworth, Yi, Yuzwa, Yuzwa, Yuzwa, Yuzwa, Zhu   +56 more
core   +1 more source

O‐GlcNAc Transferase Promotes Metabolic Dysfunction‐Associated Steatotic Liver Disease‐Related Hepatocellular Carcinoma by Facilitating the Degradation of PTEN

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Lipid‐rich and hypoxia tumor microenvironment elevates O‐GlcNAc transferase (OGT) expression, catalyzing O‐GlcNAcylation of phosphatase and tensin homolog deleted on chromosome ten (PTEN) which in turn negatively regulates PTEN to promotes the growth of hepatocellular carcinoma (HCC).
Haoran Liu, Suming Pu, Wenxin Zhu, Jing Huang, Jianming Li   +4 more
wiley   +1 more source

The glycosyltransferase EOGT regulates adropin expression in decidualizing human endometrium [PDF]

, 2017
In pregnancy, resistance of endometrial decidual cells to stress signals is critical for the integrity of the feto-maternal interface and, by extension, survival of the conceptus. O-GlcNAcylation is an essential post-translational modification that links
Alam, Mohammad T., Aplin, John D., Barros, Flavio S. V., Brosens, Jan J., Ewington, Lauren J., Muter, Joanne, Ruane, Peter T., Vrljicak, Pavle, Westwood, Melissa   +8 more
core   +2 more sources

Astragalus Polysaccharide Enhances O‐GlcNAcylation Through OGT to Improve Intervertebral Disc Degeneration in Rats

Journal of Cellular and Molecular Medicine, Volume 29, Issue 23, December 2025.
ABSTRACT Astragalus polysaccharides (APS) are a crucial bioactive component known for their various pharmacological properties. Abnormal O‐linked β‐N‐acetylglucosamine modification (O‐GlcNAcylation) is noted in cases of intervertebral disc degeneration (IVDD).
Hao Tan, Cao Fang, Yiyun Tan, Zhi Wang, Yun Zhou, Xing Li   +5 more
wiley   +1 more source

Deciphering the functions of O-GlcNAc glycosylation in the brain: The role of site-specific quantitative O-GlcNAcomics [PDF]

, 2018
The dynamic posttranslational modification O-linked β-N-acetylglucosamine glycosylation (O-GlcNAcylation) is present on thousands of intracellular proteins in the brain.
Hsieh-Wilson, Linda C., Sorum, Alexander W., Thompson, John W.   +2 more
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