Results 71 to 80 of about 4,448 (184)

Design and synthesis of naphthalimide group-bearing thioglycosides as novel β-N-acetylhexosaminidases inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
GH20 human β-N-acetylhexosaminidases (hsHex) and GH84 human O-GlcNAcase (hOGA) are involved in numerous pathological processes and emerged as promising targets for drug discovery. Based on the catalytic mechanism and structure of the catalytic domains of
Shengqiang Shen, Wei Chen, Lili Dong, Qing Yang, Huizhe Lu, Jianjun Zhang   +5 more
doaj   +1 more source

The Role of O-GlcNAcylation in Immune Cell Activation

Frontiers in Endocrinology, 2021
O-GlcNAcylation is a dynamic post-translational modification where the sugar, O-linked β-N-acetylglucosamine (O-GlcNAc) is added to or removed from various cytoplasmic, nuclear, and mitochondrial proteins.
Amy Qiang, Chad Slawson, Patrick E. Fields   +2 more
doaj   +1 more source

Glycosylation with O-linked β-N-acetylglucosamine (O-GlcNAc) induces vascular dysfunction via production of superoxide anion/reactive oxygen species [PDF]

, 2018
Overproduction of superoxide anion (•O2-) and O-linked β-N-acetylglucosamine (O-GlcNAc)-modification in the vascular system are contributors to endothelial dysfunction.
Alves-Lopes, Rhéure, Dela Justina, Vanessa, Giachini, Fernanda Regina, Lima, Victor V., Mestriner, Fabíola Leslie, Neves, Karla Bianca, Silva Miguez, Jéssica, Souza-Silva, Leonardo, Tostes, Rita C.   +8 more
core   +2 more sources

N‐Acetylglucosamine Selectively Attenuates Neuroinflammation in a Mouse Model of Mitochondrial Dysfunction

Acta Physiologica, Volume 242, Issue 3, March 2026.
ABSTRACT Aim Mitochondrial dysfunction plays a central role in multiple neurodegenerative diseases, yet the temporal sequence of cellular events underlying neurodegeneration remains poorly defined. This study aimed to characterize the progression of neurodegeneration in a mouse model of fatal mitochondrial encephalopathy and to evaluate the therapeutic
Laura Jiménez‐Sánchez, Paula Ruiz‐López, Pilar González‐García, Janne Purhonen, Juan Manuel Martínez‐Gálvez, Sergio López‐Herrador, Julia Corral‐Sarasa, María Elena Díaz‐Casado, Carmen Venegas, Isaac Santos‐Pérez, Enrica Olivieri, Adriana L. Rojas, Luis Carlos López   +12 more
wiley   +1 more source

Characterization of tools to detect and enrich human and mouse O-GlcNAcase. [PDF]

Glycobiology, 2017
O-linked β-N-acetylglucosamine (O-GlcNAc) is an essential regulatory post-translational modification of thousands of nuclear, cytoplasmic, and mitochondrial proteins. O-GlcNAc is dynamically added and removed from proteins by the O-GlcNAc transferase and the O-GlcNAcase (OGA), respectively.
Groves JA, Zachara NE.
europepmc   +4 more sources

Three Decades of Research on O-GlcNAcylation – A Major Nutrient Sensor That Regulates Signaling, Transcription and Cellular Metabolism [PDF]

, 2014
Even though the dynamic modification of polypeptides by the monosaccharide, O-linked N-acetylglucosamine (O-GlcNAcylation) was discovered over thirty-years ago, its physiological significance as a major nutrient sensor that regulates myriad cellular ...
Gerald W. Hart
core   +2 more sources

Maternal O‐GlcNAc Transferase Is Required for the Asymmetry of Epigenetic Modifications in Mouse Zygotes

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
OGT inhibition during in vitro oocyte maturation disrupts epigenetic asymmetry in the zygote. It reduces male pronuclear size and eliminates DNA methylation asymmetry by decreasing H3K9me2‐mediated 5mC protection in the female pronucleus and suppressing TET3‐dependent DNA demethylation in the male pronucleus.
Haoxue Wang, Dan Liu, Shinnosuke Honda, Shuntaro Ikeda   +3 more
wiley   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

Results of the first-in-human, randomized, double-blind, placebo-controlled, single- and multiple-ascending dose study of BIIB113 in healthy volunteers

The Journal of Prevention of Alzheimer's Disease
Background: Preclinical studies have demonstrated that inhibition of the O-linked β-N-acetylglucosaminidase enzyme increases tau O-linked β-N-acetylglucosaminylation and may attenuate tau pathology in Alzheimer’s disease.
Flavia C. Nery, Maciej Kaliszczak, Ben Suttle, Lori Jones, Shuang Wu, Jing Xie, Gioacchino Curiale, Esin Yesilalan, Beth Hirschhorn, Denisa Wilkes, Dave Singh, Martin Bolin, Sangram Nag, Andrea Varrone, Per Stenkrona, Anton Forsberg Morén, Christer Halldin, Jeffrey Yachnin, H. Moore Arnold, Szofia Bullain, Jaren Landen, Diana Gallagher, Heike Hering   +22 more
doaj   +1 more source

Functional Analysis of O-GlcNAcylation in Cancer Metastasis

Frontiers in Oncology, 2020
One common and reversible type of post-translational modification (PTM) is the addition of O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation), and its dynamic balance is controlled by O-GlcNAc transferase (OGT) and glycoside ...
Donglu Wu, Donglu Wu, Jingji Jin, Zhidong Qiu, Zhidong Qiu, Da Liu, Da Liu, Haoming Luo, Haoming Luo   +8 more
doaj   +1 more source