Results 61 to 70 of about 4,448 (184)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

O-GlcNAcylation: A Sweet Hub in the Regulation of Glucose Metabolism in Health and Disease

Frontiers in Endocrinology, 2022
O-GlcNAcylation is a posttranslational modification ruled by the activity of a single pair of enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA).
Maria J. Gonzalez-Rellan, Marcos F. Fondevila, Marcos F. Fondevila, Carlos Dieguez, Carlos Dieguez, Ruben Nogueiras, Ruben Nogueiras   +6 more
doaj   +1 more source

Production of Glycopeptide Derivatives for Exploring Substrate Specificity of Human OGA Toward Sugar Moiety. [PDF]

, 2018
O-GlcNAcase (OGA) is the only enzyme responsible for removing N-acetyl glucosamine (GlcNAc) attached to serine and threonine residues on proteins. This enzyme plays a key role in O-GlcNAc metabolism.
Chen, Xi, Chen, Yi, Guo, Jianshuang, Li, Jing, Li, Shanshan, Li, Yanhong, Wang, Jiajia, Wang, Peng George, Wen, Liuqing, Zang, Lanlan, Zhang, Jiabin, Zhu, Hailiang   +11 more
core  

The effect of peri-conception hyperglycaemia and the involvement of the hexosamine biosynthesis pathway in mediating oocyte and embryo developmental competence [PDF]

, 2014
The environment that the oocyte is exposed to during the peri-conception period can have a significant impact on oocyte developmental competence (the ability of the oocyte to support fertilisation and subsequent embryo development) and the long-term ...
Akimoto, Akimoto, Ali, Alvino, Anderson, Arias, Arias, Arnot, Assidi, Baccetti, Badet, Banfalvi, Becerra, Bell, Bergh, Biggers, Boney, Brownlee, Buse, Butkinaree, Caixeta, Carrette, Casson, Cetica, Chalepakis, Chang, Chatot, Chatot, Chen, Cheng, Cheng, Chou, Chou, Chou, Colton, Colton, Comer, Comer, Copeland, Cornblath, Dalton, Datta, DeHaven, Diamond, Dokras, Dong, Downs, Downs, Downs, Downs, Du, Dunne, Dunning, El Shourbagy, El-Sayed, Eppig, Eppig, Farrell, Fleming, Frank, Frank, Frolova, Funahashi, Fuster, Gao, Gardner, Greene, Grondahl, Guerin, Gupta, Gutnisky, Haltiwanger, Haltiwanger, Haltiwanger, Harris, Hart, Hashimoto, Hedderson, Hendryx, Holing, Holt, Horal, Jimenez, Johnson, Julenius, Jungheim, Jungheim, Kang, Kanji, Kelly, Kim, Kreppel, Kreppel, Kreppel, Kumar, Lapolla, Lapolla, Lazarus, Lea, Leese, Leese, Lefebvre, Lubas, Lubas, Luciano, Marquard, Marshall, Marshall, Marshall, McClain, Medina, Merriman, Metwally, Middleton, Mikkelsen, Milewski, Miller, Mills, Mills, Moley, Moley, Moley, Moley, Monauni, Nandi, Nataprawira, Nelkin, Nelson, Nishimoto, Norman, O'Brien, Oh, Oki, Pantaleon, Pantaleon, Park, Parker, Patti, Pearson, Petersen, Purcell, Ratchford, Ray, Reece, Rich-Edwards, Roberts, Robker, Robker, Rolo, Roquemore, Roquemore, Runft, Russell, Sadler, Salustri, Santos, Sayeski, Sayeski, Schaefer, Schelbach, Schelbach, Seshiah, Shafi, Silverman, Slawson, Slawson, Slawson, Steeves, Stothard, Sturmey, Suhonen, Sutton, Sutton-McDowall, Sutton-McDowall, Sutton-McDowall, Sutton-McDowall, Sutton-McDowall, Tamassia, Tanghe, The Jackson Laboratory, Thompson, Thomson, Torres, Tsai, Uldry, Unwin, Van Blerkom, Van den Steen, Virkamaki, Vosseller, Vosseller, Wang, Wang, Wang, Wang, Webb, Wells, Wells, Wells, Whelan, Wilkinson, Williams, Wittmaack, Wongsrikeao, Woolford, Wyman, Xu, Yang, Yang, Yang, Zachara, Zachara, Zachara, Zhang, Zhang, Zhou   +215 more
core   +1 more source

OGA Inhibition By GlcNAc-Selenazoline [PDF]

, 2010
The title compound, which differs from the powerful O-GlcNAcase (OGA) inhibitor GlcNAc-thiazoline only at the chalcogen atom (Se for S), is a much weaker inhibitor in a direct OGA assay.
Abdo, M., Darout, E., Hanover, J. A., Kim, E. J., Knapp, S., Love, D. C., Rablen, Paul R., Rempel, B., Withers, S. G.   +8 more
core   +2 more sources

Hyperglycaemia‐induced reactive oxygen species production in cardiac ventricular myocytes differs among mammals

The Journal of Physiology, EarlyView.
Abstract figure legend In rat and human adult ventricular myocytes, acute hyperglyceaemia (Glucose) causes increased glucose uptake (via GLUT) leading to O‐GlcNAcylation of CaMKII at Ser280, such that CaMKII activates NADPH oxidase 2 (NOX2) to increase cytosolic reactive oxygen species (ROS). That perturbs the ROS to Antioxidant (AntiOx) balance.
Shan Lu, Maria J. Baier, Risto‐Pekka Polonen, Zhandi Liao, Jody L. Martin, Kenneth S. Ginsburg, Julian Mustroph, Donald M. Bers   +7 more
wiley   +1 more source

Modulation of synaptic transmission through O-GlcNAcylation

Molecular Brain
O-GlcNAcylation is a posttranslational modification where N-acetylglucosamine (O-GlcNAc) is attached and detached from a serine/threonine position by two enzymes: O-GlcNAc transferase and O-GlcNAcase.
Seunghyo Han, Jun-Nyeong Kim, Chan Ho Park, Jin-Seok Byun, Do-Yeon Kim, Hyoung-Gon Ko   +5 more
doaj   +1 more source

O-GlycNacylation Remission Retards the Progression of Non-Alcoholic Fatty Liver Disease

Cells, 2022
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease spectrum associated with insulin resistance (IR), from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC).
Yicheng Zhou, Zhangwang Li, Minxuan Xu, Deju Zhang, Jitao Ling, Peng Yu, Yunfeng Shen   +6 more
doaj   +1 more source

Thio-linked UDP-peptide conjugates as O-GlcNAc transferase inhibitors [PDF]

, 2018
O-GlcNAc transferase (OGT) is an essential glycosyltransferase that installs the O-GlcNAc post-translational modification on the nucleocytoplasmic proteome. We report the development of S-linked UDP–peptide conjugates as potent bisubstrate OGT inhibitors.
Andrii Gorelik, Bogachev V. S., Daan M. F. van Aalten, Derossi D., Dong D. L., Karim Rafie, Riccardo Trapannone, Torres C. R., Vladimir S. Borodkin   +8 more
core   +3 more sources

Post‐translational Modifications in Proteins: Prediction Methods, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Posttranslational modifications (PTMs) serve as rapid and reversible molecular switches that reshape protein activity, stability, and interactomes, thereby governing virtually all physiological cues ranging from signal transduction to epigenetic memory. Mass spectrometry‐based proteomics has substantially expanded our understanding of PTM emergence and
Shuning Zhang, Jingmin Li, Meihuan Chen, Hailong Huang   +3 more
wiley   +1 more source