Results 81 to 90 of about 4,448 (184)

Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation [PDF]

, 2017
O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O ...
AL Mammen, AT Huddleston, BD Lazarus, BQ Liu, C Betzen, C Kim, CS Arnold, DJ Whitcomb, E Benito, EW Taylor, F Liu, GA Ngoh, GW Hart, HJ Goldberg, HK Lee, J Boehm, J Jo, J Lisman, JE Rexach, JF Alfaro, JH Morrison, JR Erickson, K Liu, K Vosseller, KW Roche, L Gong, LS Griffith, LS Griffith, LT Knapp, M Ogawa, M Robles-Flores, M Tiedge, MK Tallent, MP Housley, NP Marotta, R Okuyama, RJ Konrad, RL Huganir, RN Cole, RN Cole, SA Yuzwa, SN Burke, T Hosokawa, T Kanno, WB Dias, Y Akimoto, Y Skorobogatko, YR Yang, YR Yang, YR Yang, YR Yang, Z Wang   +51 more
core   +1 more source

An OGT Missense Variant With Impaired Enzyme Activity in a Child With Severe Developmental Delay and Hepatoblastoma

American Journal of Medical Genetics Part A, Volume 200, Issue 2, Page 502-510, February 2026.
ABSTRACT O‐GlcNAc transferase (OGT) and its antagonist O‐GlcNAcase (OGA) regulate protein O‐GlcNAcylation, a highly conserved post‐translational modification involved in metabolic sensing. Pathogenic variants in the OGT gene cause an X‐linked congenital disorder of glycosylation (OGT‐CDG) presenting developmental delay, hypotonia, intellectual ...
Alfonso Manuel D'Alessio, Huijie Yuan, Leandro Raul Soria, Sara Basse Hansen, Iolanda Boffa, Paola Arena, Benedetta Attianese, Maureen. O'Sullivan, Noelle Cullinan, Lewis Pang, Daan Marinus Ferdinand van Aalten, Nicola Brunetti‐Pierri, Sally Ann Lynch   +12 more
wiley   +1 more source

‘O-GlcNAc Code’ Mediated Biological Functions of Downstream Proteins

Molecules, 2018
As one of the post-translational modifications, O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) often occurs on serine (Ser) and threonine (Thr) residues of specific substrate cellular proteins via the addition of O-GlcNAc ...
Linhong Zhao, Junaid Ali Shah, Yong Cai, Jingji Jin   +3 more
doaj   +1 more source

Acid-catalysed carboxymethylation, methylation and dehydration of alcohols and phenols with dimethyl carbonate under mild conditions [PDF]

, 2016
Dimethyl carbonate (DMC) chemistry has been extended to include acid-catalysed reactions of different aliphatic alcohols and phenols. For the first time, p-toluenesulfonic acid (PTSA), H2SO4, AlCl3 and FeCl3 have been shown to aid carboxymethylation for ...
Clark, James H., Hunt, Andrew J., Jin, Saimeng, McElroy, Con Robert   +3 more
core   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Transcript‐Level Modulation of O‐GlcNAc Transferase for Aging‐Related Neurodegenerative Diseases

ChemBioChem, Volume 27, Issue 2, January 2026.
O‐GlcNAc Transferase (OGT) and O‐GlcNAcase (OGA) maintain O‐GlcNAc homeostasis, but OGT expression and activity decline in the aging brain, promoting protein aggregation and neurodegeneration. Current approaches raise O‐GlcNAc levels via OGA inhibition. New insights into OGT splicing enable direct OGT upregulation using ASO‐ or PROTAC‐based strategies,
Florian Malard
wiley   +1 more source

Solving the mystery of human sleep schedules one mutation at a time. [PDF]

, 2013
Sleep behavior remains one of the most enigmatic areas of life. The unanswered questions range from "why do we sleep?" to "how we can improve sleep in today's society?" Identification of mutations responsible for altered circadian regulation of human ...
Fu, Ying-Hui, Hallows, William C, Ptáček, Louis J   +2 more
core   +1 more source

Regulatory mechanism of O‐linked N‐acetylglucosamine protein modification on autophagy in cancer

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
O‐GlcNAcylation serves as a nutrient and stress sensor that dynamically regulates autophagy at multiple stages in cancer cells. It fine‐tunes autophagy initiation, maturation and fusion by modifying key proteins such as ULK1, ATG4B and SNAP‐29. Context‐dependent O‐GlcNAcylation promotes tumour adaptation and therapy resistance via autophagy remodelling.
Yizhan Li, Ling Gao, Shaoming Li, Jingjing Zheng, Keqian Zhi, Wenhao Ren   +5 more
wiley   +1 more source

Cardiac transcription factor Nkx2.5 is downregulated under excessive O-GlcNAcylation condition. [PDF]

PLoS ONE, 2012
Post-translational modification of proteins with O-linked N-acetylglucosamine (O-GlcNAc) is linked the development of diabetic cardiomyopathy. We investigated whether Nkx2.5 protein, a cardiac transcription factor, is regulated by O-GlcNAc.
Hoe Suk Kim, Ji Soo Woo, Hyun Jung Joo, Woo Kyung Moon   +3 more
doaj   +1 more source

T Cell O‐GlcNAcylation Increases in Patients With Allergic Rhinitis After the Natural Pollen Season

Clinical &Experimental Allergy, EarlyView.
Eduardo I. Cardenas, Maryam Jafari, Emma Nilsson, Agnetha Karlsson, Marianne Petro, Monika Ezerskyte, Ola Winqvist, Lars Olaf Cardell   +7 more
wiley   +1 more source