Bile acids at the cross-roads of gut microbiome–host cardiometabolic interactions [PDF]
, 2017 This work is supported in part by the APC Microbiome Institute (under Science Foundation Ireland [SFI] Grant Number: SFI/12/RC/2273) and by Enterprise Ireland Commercialization Fund (Contract Reference: CF/2013/3030A/B).peer-reviewedWhile basic and ...
Caplice, Noel M +2 more
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Can Pharmacologic Therapy Induce Histologic Improvement in Non-alcoholic Steatohepatitis?
The Korean Journal of Gastroenterology, 2016 Articles: Farnesoid X Nuclear Receptor Ligand Obeticholic Acid for Non-cirrhotic, Non-alcoholic Steatohepatitis (FLINT): a Multicentre, Randomised, Placebo-controlled Trial (Lancet 2015;385:956-965) Liraglutide Safety and Efficacy in Patients with Non ...
Nae-Yun Heo
doaj +1 more source
Farnesoid X receptor (FXR): Structures and ligands
Computational and Structural Biotechnology Journal, 2021 Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly expressed in the liver and intestine. Upon ligand binding, FXR regulates key genes involved in the metabolic process of bile acid synthesis, transport and ...
Longying Jiang +4 more
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The relationship between gut microbiota and spontaneous bacterial peritonitis in patients with liver cirrhosis - a literature review [PDF]
, 2019 Gut microbiota is an essential component in the pathogenesis of liver cirrhosis and its complications. There is a direct relationship between the gut and the liver called the gutliver axis through which bacteria can reach the liver through the portal ...
Fierbinteanu Braticevici, Carmen +9 more
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miR-22 inhibition reduces hepatic steatosis via FGF21 and FGFR1 induction
JHEP Reports, 2020 Background & Aims: Metabolism supports cell proliferation and growth. Surprisingly, the tumor suppressor miR-22 is induced by metabolic stimulators like bile acids. Thus, this study examines whether miR-22 could be a metabolic silencer.
Ying Hu +5 more
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Impact of Primary and Secondary Bile Acids on Clostridioides difficile Infection
Polish Journal of Microbiology, 2022 Primary bile acids (BAs), synthesized from cholesterol in the liver, after their secretion with bile into the intestinal lumen, are transformed by gut microbiota to secondary BAs. As natural detergents, BAs play a key role in the digestion and absorption
Łukawska Agata, Mulak Agata
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Pharmacotherapy for Nonalcoholic Fatty Liver Disease [PDF]
, 2015 Lifestyle modifications and optimization of the management of cardiometabolic comorbidities are currently the mainstay of treatment for patients with nonalcoholic fatty liver disease.
Chalasani, Naga, Gawrieh, Samer
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Nem alkoholos zsírmáj és hepatocellularis carcinoma – 2016 [PDF]
, 2016 Absztrakt Az utolsó évtizedben a fejlett országokban a nem alkoholos zsírmáj lett a leggyakrabban diagnosztizált krónikus májbetegség.
Pár, Alajos, Pár, Gabriella
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Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis
Acta Pharmaceutica Sinica B, 2019 Obeticholic acid (OCA), the first FXR-targeting drug, has been claimed effective in the therapy of liver fibrosis. However, recent clinical trials indicated that OCA might not be effective against liver fibrosis, possibly due to the lower dosage to ...
Jiyu Zhou +9 more
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Farnesoid X Receptor as Target for Therapies to Treat Cholestasis-Induced Liver Injury
Cells, 2021 Recent studies on liver disease burden worldwide estimated that cirrhosis is the 11th most common cause of death globally, and there is a great need for new therapies to limit the progression of liver injuries in the early stages.
Anca D. Petrescu, Sharon DeMorrow
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