Results 81 to 90 of about 6,789 (241)
Diagnosis and Treatment of Primary Biliary Cholangitis
The Korean Journal of Gastroenterology, 2023 Primary biliary cholangitis (PBC) is an autoimmune disease prevalent in middle-aged women and characterized by chronic cholestasis. PBC is diagnosed when at least two of the following three criteria are met: elevated alkaline phosphatase, presence of PBC-
Kyung-Ah Kim
doaj +1 more source
European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a major global cause of liver disease, driven by obesity and insulin resistance (IR). IR promotes hepatic lipid accumulation, inflammation and mitochondrial dysfunction, accelerating MASLD progression to fibrosis, cirrhosis and hepatocellular carcinoma (HCC).
Alfredo Caturano +15 more
wiley +1 more source
Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease. [PDF]
, 2019 The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract, encodes several orders of magnitude more functional genes than the human genome. It also plays a pivotal role in human health, in part due to metabolism
Lynch, Susan V +3 more
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Reduction and stabilization of bilirubin with obeticholic acid treatment in patients with primary biliary cholangitis [PDF]
, 2020 Total bilirubin is a predictor of survival in primary biliary cholangitis, with the main elevated component being direct bilirubin. The purpose of this post hoc analysis was to assess the efficacy and safety of obeticholic acid across quartiles of ...
Hirschfield, Gideon +7 more
core +2 more sources
Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases
Advanced Science, Volume 12, Issue 48, December 29, 2025.Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu +9 more
wiley +1 more source
New developments in the treatment of primary biliary cholangitis – role of obeticholic acid
Therapeutics and Clinical Risk Management, 2017 Manan A Jhaveri, Kris V Kowdley Liver Care Network, Swedish Medical Center, Seattle, WA, USA Abstract: Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease that predominantly affects women in early to middle age.
Jhaveri MA, Kowdley KV
doaj
In Silico Analysis Identifies Intestinal Transit as a Key Determinant of Systemic Bile Acid Metabolism [PDF]
, 2018 Bile acids fulfill a variety of metabolic functions including regulation of glucose and lipid metabolism. Since changes of bile acid metabolism accompany obesity, Type 2 Diabetes Mellitus and bariatric surgery, there is great interest in their role in ...
Eggink, Hannah M +5 more
core +3 more sources
Clinical Case Reports, Volume 13, Issue 12, December 2025.ABSTRACT Multiple autoimmune syndrome involves the concurrent presentation of at least three separate autoimmune conditions in one individual. When patients present with both autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) simultaneously, it is referred to as AIH‐PBC overlap syndrome.
Tahmina Haque +5 more
wiley +1 more source
Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease. [PDF]
, 2019 Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous and complex disease that is imprecisely diagnosed by liver biopsy. NAFLD covers a spectrum that ranges from simple steatosis, nonalcoholic steatohepatitis (NASH) with varying degrees of fibrosis,
Alonso, Cristina +3 more
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