Results 121 to 130 of about 67,898 (346)

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

open access: yesAdvanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan   +16 more
wiley   +1 more source

Effects and underlying mechanisms of ginsenoside Rb1 in improving non-alcoholic steatohepatitis via modulation of the gut-liver axis

open access: yes陆军军医大学学报
Objective To investigate the therapeutic effects of ginsenoside Rb1 on non-alcoholic steatohepatitis (NASH) and its mechanisms through modulating gut microbiota and repairing intestinal barriers in liver inflammation and metabolic disorders. Methods
FU Hui, FU Hui, XU Benjin
doaj   +1 more source

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

open access: yesAdvanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao   +18 more
wiley   +1 more source

Determination of intercellular contacts in patients with irritable bowel syndrome

open access: yesGastroenterologìa, 2019
The article presents an analysis of literature data on the violation of intestinal permeability as one of the pathogenetic factors of irritable bowel syndrome. The structure of tight junctions is considered in detail as an important element of the normal
Yu.M. Stepanov   +2 more
doaj   +1 more source

Campylobacter concisus Impairs Sodium Absorption in Colonic Epithelium via ENaC Dysfunction and Claudin-8 Disruption [PDF]

open access: yes, 2020
The epithelial sodium channel (ENaC) can increase the colonic absorptive capacity for salt and water. Campylobacter concisus is a common pathogenic epsilonproteobacterium, causing enteritis and diarrhea. It can induce barrier dysfunction in the intestine,
Bereswill, Stefan   +15 more
core   +2 more sources

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

open access: yesAdvanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen   +11 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

open access: yesHepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández   +18 more
wiley   +1 more source

Lipid peroxidation induced by DHA enrichment modifies paracellular permeability in Caco-2 cells

open access: yesJournal of Lipid Research, 2004
Dietary enrichment with docosahexaenoic acid (DHA) has numerous beneficial effects on health. However, the intake of high doses of polyunsaturated fatty acids can promote lipid peroxidation and the subsequent propagation of oxygen radicals.
Sònia Roig-Pérez   +3 more
doaj   +1 more source

Occludin knockdown is not sufficient to induce transepithelial macromolecule passage

open access: yesTissue Barriers, 2019
Occludin, a tight junction protein, has been reported to regulate barrier function – particularly the leak pathway for larger solutes – in epithelia. Therefore, we aimed to precisely define its role in macromolecule passage at single cell–cell junctions.
J. Richter   +5 more
semanticscholar   +1 more source

Characterization of a continuous feline mammary epithelial cell line susceptible to feline epitheliotropic viruses. [PDF]

open access: yes, 2009
Mucosal epithelial cells are the primary targets for many common viral pathogens of cats. Viral infection of epithelia can damage or disrupt the epithelial barrier that protects underlying tissues.
Heymer, Anna   +8 more
core  

Home - About - Disclaimer - Privacy