Results 241 to 250 of about 55,164 (304)

Integrated Multi‐Omic Analysis Identifies Altered Colonic Brush Border Profile as a Key Feature of Microscopic Colitis

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background Microscopic colitis (MC), comprising lymphocytic colitis (LC) and collagenous colitis (CC), is an inflammatory bowel disease with increasing incidence. MC etiopathogenesis remains unknown; however, altered colonic epithelial integrity may underlie uncontrolled luminal antigen passage, triggering immuno‐inflammatory responses ...
Danila Guagnozzi, Ana Maria Gonzalez‐Castro, Yamile Zabana, Fernando Fernández‐Bañares, Andreas Münch, Eva Tristan, Juan‐José Lozano, Julia Sidorova, Beatriz Lobo, Carmen Alonso‐Cotoner, Elba Exposito, Alfredo J. Lucendo, Stefania Landolfi, Ana Benages, Ronald Llerena‐Castro, Maria Dolores Castillo Cejas, Joan Dot, Javier Santos, Maria Vicario   +18 more
wiley   +1 more source

Aspartic protease 2 from Trichinella spiralis excretion/secretion products hydrolyzes tight junctions of intestinal epithelial cells. [PDF]

PLoS Negl Trop Dis
Long SR, Zhang HR, Wang JJ, Liao ZX, Fan QX, Liang YQ, Gan CY, Liu RD, Cui J, Zhang X, Wang ZQ, Qi X.   +11 more
europepmc   +1 more source

Resveratrol attenuates areca nut extract‐induced chronic colitis by suppressing pyroptosis of intestinal epithelial cells via modulating cGAS/STING signaling

VIEW, Volume 7, Issue 1, February 2026.
Areca nut extract (ANE), commonly consumed in some cultures, can damage gut cells by triggering inflammation and cell death through a pathway called cGAS‐STING. This leads to the release of harmful inflammatory substances and weakens the gut barrier. Our study shows that resveratrol, a natural compound found in foods like grapes, can block this harmful
Jing Zhang, Muhammad Tufail, Yu‐Qi Huang, Can‐Hua Jiang, Ning Li   +4 more
wiley   +1 more source

Chronic alcohol consumption disrupts the integrity of the blood-brain barrier through the gut-brain axis. [PDF]

Commun Biol
Li C, Wang H, Lin X, Zeng G, Li X, Chen W, Lu H, Pan J, Zhang X, Rong X, He L, Peng Y.   +11 more
europepmc   +1 more source

Obesity Impairs Skin Barrier Function and Facilitates Allergic Sensitization in Mice

Allergy, Volume 81, Issue 2, Page 498-512, February 2026.
Diet‐induced obesity increases transepidermal water loss and compromises barrier function through downregulation of tight junctions and desmosomes. During obesity, MC903 elicits a mixed Th1/2/17 immune response in the skin leading to aggravated ear swelling.
Alicia Martinek, Andrea Deinzer, Roman G. Gerlach, Jana Petzold, Lea Semmler, Christof Vorsatz, Padraic G. Fallon, Christian Schwartz   +7 more
wiley   +1 more source

Berberine Alleviates Shigella-Induced Dysentery by Regulating Intestinal Barrier and Inflammatory Responses. [PDF]

Int J Mol Sci
Ding J, Zhang Y, Fan X, Han Y, Lin Y.
europepmc   +1 more source

Luteolin Inhibits NLRP3 Inflammasome Activation to Ameliorate DSS‐Induced Colitis by Regulating AMPK Signalling

Cell Proliferation, Volume 59, Issue 2, February 2026.
Luteolin alleviates DSS‐induced ulcerative colitis in mice by targeting the NLRP3 inflammasome, as it shows no effect in NLRP3‐/‐ mice. It inhibits NLRP3 activation and IL‐1β secretion in macrophages by reducing ROS, mtROS and calcium levels via AMPK binding and signalling. Metabolomic changes suggest lipid metabolism involvement. Luteolin represents a
Lianxiang Luo, Fangfang Huang, Guixuan Fang, Yiming Sun, Liyan Deng, Yinglin Liao, Xinming Chen, Zhuosi Chen, Xinxun Lin   +8 more
wiley   +1 more source

Tissue Regression-Related Alterations in the Expression of Adherens and Tight Junction Proteins in the Hen Oviduct. [PDF]

Int J Mol Sci
Frydrych K, Hrabia A.
europepmc   +1 more source

Ethanol Alters DNMT1/3a/3b Expression Profile, Promotes Persistent DNA Hypomethylation in Human Brain Endothelial Cells and Impairs Late Cortical Angiogenesis

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Ethanol exposure alters brain endothelial cell function and blood–brain barrier integrity. In human brain microcapillary endothelial cells (HBMEC) and mouse brain endothelial cells (MBEC) from a prenatal alcohol exposure (PAE) model, ethanol increased DNA methyltransferas‐1 (DNMT1) activity and reduced DNA methylation, affecting DNMT3a/3b, methyl‐CpG ...
Michele Siqueira, Matheus Barros, Paula Lacerda Almeida, Luiza dos Santos Heringer, Henrique Rocha Mendonça, Flávia Carvalho Alcantara Gomes, Joice Stipursky   +6 more
wiley   +1 more source