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Occludin Phosphorylation in Regulation of Epithelial Tight Junctions [PDF]
Annals of the New York Academy of Sciences, 2009 Occludin is the first transmembrane protein of the tight junction to be discovered. While numerous studies emphasized the important role of occludin in assembly and maintenance of tight junctions, occludin knockout studies indicated that it was not required for tight junction assembly in different epithelia.
Radhakrishna Rao
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Casein kinase Iε associates with and phosphorylates the tight junction protein occludin [PDF]
FEBS Letters, 2006 Occludin is an integral-membrane protein that contributes to tight junction function. We have identified casein kinase Iε (CKIε) as a binding partner for the C-terminal cytoplasmic domain of occludin by yeast two-hybrid screening.
Anne J Ridley
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Occludin Regulates Actin Cytoskeleton in Endothelial Cells.
Cell Structure and Function, 2001 Occludin is a major membrane component of tight junctions of endothelial cells, though the role of this molecule is not fully understood. RLE cells, derived from rat lung endothelial cells, express a negligible level of occludin with clear expression of E-cadherin and ZO-1 at cell junctions.
Yasuo Kokai +2 more
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Occludin: Structure, function and regulation
Advanced Drug Delivery Reviews, 2005Epithelial and/or endothelial barriers play a critical role in animal, including human, life forms. The tight junction (TJ) is an essential component of these barriers. Occludin is a major component of the TJ. The structure of occludin, including its gene splice variants and protein essential components have been elucidated.
Gemma J, Feldman +2 more
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Occludin is a functional component of the tight junction
Journal of Cell Science, 1996ABSTRACT Occludin’s role in mammalian tight junction activity was examined by ‘labeling’ the occludin pool with immunologically detectable chick occludin. This was accomplished by first transfecting MDCK cells with the Lac repressor gene.
K M, McCarthy +7 more
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Subcellular Distribution of Tight Junction-Associated Proteins (Occludin, ZO-1, ZO-2) in Rodent Skin [PDF]
Journal of Investigative Dermatology, 1998 Occludin is an integral membrane protein that is concentrated at tight junctions (zonulae occludentes) in simple epithelial cells. ZO-1 and ZO-2 are peripheral membrane proteins that are localized at tight junctions in simple epithelial cells and at ...
Kazumasa Morita +2 more
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Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier [PDF]
American Journal of Physiology - Renal Physiology, 2011 Defective intestinal epithelial tight junction (TJ) barrier has been shown to be an important pathogenic factor contributing to the development of intestinal inflammation.
Rana Al-Sadi, Shuhong Guo, Dongmei Ye
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Identification of an Occludin Cell Adhesion Recognition Sequence
Inflammation, 2002The molecular mechanisms by which the tight junction integral membrane protein, occludin promotes cell adhesion and establishes an endothelial monolayer permeability barrier have not been elucidated. In particular, the amino acid sequences of the occludin cell adhesion recognition (CAR) sites have not been determined.
Orest W, Blaschuk +11 more
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Caveolin binds independently to claudin‐2 and occludin
Annals of the New York Academy of Sciences, 2012Treatment of epithelial and endothelial cells with proinflammatory cytokines can stimulate tight junction protein endocytosis, with associated loss of physiologic barrier function. In some instances, the endocytic scaffolding protein, caveolin‐1, has been implicated in the cytokine‐dependent retrieval of the tight junction proteins occludin and ...
Christina M Van, Itallie +1 more
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