Results 271 to 280 of about 56,078 (308)

Occludin: Structure, function and regulation

Advanced Drug Delivery Reviews, 2005
Epithelial and/or endothelial barriers play a critical role in animal, including human, life forms. The tight junction (TJ) is an essential component of these barriers. Occludin is a major component of the TJ. The structure of occludin, including its gene splice variants and protein essential components have been elucidated.
Gemma J, Feldman, James M, Mullin, Michael P, Ryan   +2 more
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Occludin is a functional component of the tight junction

Journal of Cell Science, 1996
ABSTRACT Occludin’s role in mammalian tight junction activity was examined by ‘labeling’ the occludin pool with immunologically detectable chick occludin. This was accomplished by first transfecting MDCK cells with the Lac repressor gene.
K M, McCarthy, I B, Skare, M C, Stankewich, M, Furuse, S, Tsukita, R A, Rogers, R D, Lynch, E E, Schneeberger   +7 more
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Phosphorylation of occludin correlates with occludin localization and function at the tight junction

American Journal of Physiology-Cell Physiology, 1997
Multiple forms of occludin were found in Madin-Darby canine kidney (MDCK) cells. In the absence of cell-to-cell contacts, achieved by incubating cells in low-calcium growth medium, a cluster of lower-molecular-weight (LMW) occludin bands (∼65,000–68,000) was present in both MDCK I and II cells. On formation of tight junctions, achieved by changing the
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Identification of an Occludin Cell Adhesion Recognition Sequence

Inflammation, 2002
The molecular mechanisms by which the tight junction integral membrane protein, occludin promotes cell adhesion and establishes an endothelial monolayer permeability barrier have not been elucidated. In particular, the amino acid sequences of the occludin cell adhesion recognition (CAR) sites have not been determined.
Orest W, Blaschuk, Tadayuki, Oshima, Barbara J, Gour, J Matthew, Symonds, Jae H, Park, Christopher G, Kevil, Steven D, Trocha, Stephanie, Michaud, Naotsuka, Okayama, John W, Elrod, J Steven, Alexander, Makoto, Sasaki   +11 more
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Caveolin binds independently to claudin‐2 and occludin

Annals of the New York Academy of Sciences, 2012
Treatment of epithelial and endothelial cells with proinflammatory cytokines can stimulate tight junction protein endocytosis, with associated loss of physiologic barrier function. In some instances, the endocytic scaffolding protein, caveolin‐1, has been implicated in the cytokine‐dependent retrieval of the tight junction proteins occludin and ...
Christina M Van, Itallie, James M, Anderson   +1 more
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Occludin confers adhesiveness when expressed in fibroblasts

Journal of Cell Science, 1997
ABSTRACT Occludin is an integral membrane protein specifically associated with tight junctions. Previous studies suggest it is likely to function in forming the intercellular seal. In the present study, we expressed occludin under an inducible promotor in occludin-null fibroblasts to determine whether this protein confers intercellular ...
C M, Van Itallie, J M, Anderson
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Expression of Occludin in Canine Testis and Epididymis

Reproduction in Domestic Animals, 2004
ContentsTight junctions (TJ) in inter‐Sertoli junctional areas and epididymal epithelia are important for the formation of blood–testis barrier (BTB) and blood–epididymal barrier (BEB). In this study, the expression of occludin, an integral member of the TJ, was verified in canine testis and epididymis.
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Occludin expression decreases with the progression of human endometrial carcinoma

Human Pathology, 2004
The tight junctions of the glandular epithelium are crucial for the maintenance of cell polarity, separating the plasma membrane into apical and basolateral domains. Thus abnormalities of the tight junctions may result in the structural disturbances of glandular epithelial neoplasia.
Hirotoshi Tobioka, Hiroshi Isomura, Yasuo Kokai   +2 more
exaly   +3 more sources

Differential Phosphorylation of Occludin and Tricellulin by CK2 and CK1

Annals of the New York Academy of Sciences, 2009
In epithelial and endothelial cell layers tight junctions form selective apicolateral paracellular barriers separating luminal and extracellular spaces from the underlying tissues. Within the tight junctions the tetraspan transmembrane proteins occludin, claudins, and tricellulin form anastomosing strands of protein complexes, which interconnect ...
Max J, Dörfel, Julie K, Westphal, Otmar, Huber   +2 more
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Occludin, a Constituent of Tight Junctions

2007
Occludin was the first tight junction (TJ) integral membrane protein identified. This ∼65 kDa protein specifically localizes at TJs of epithelial and endothelial cells and is incorporated into the network of TJ strands. Occludin has a predicted tetraspan membrane topology with two extracellular loops and a large COOH-terminal cytoplasmic domain.
Yan-Hua Chen, Daniel A. Goodenough, Qun Lu   +2 more
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