Results 271 to 280 of about 55,164 (304)

Phosphorylation of occludin correlates with occludin localization and function at the tight junction

American Journal of Physiology-Cell Physiology, 1997
Multiple forms of occludin were found in Madin-Darby canine kidney (MDCK) cells. In the absence of cell-to-cell contacts, achieved by incubating cells in low-calcium growth medium, a cluster of lower-molecular-weight (LMW) occludin bands (∼65,000–68,000) was present in both MDCK I and II cells. On formation of tight junctions, achieved by changing the
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Identification of an Occludin Cell Adhesion Recognition Sequence

Inflammation, 2002
The molecular mechanisms by which the tight junction integral membrane protein, occludin promotes cell adhesion and establishes an endothelial monolayer permeability barrier have not been elucidated. In particular, the amino acid sequences of the occludin cell adhesion recognition (CAR) sites have not been determined.
Orest W, Blaschuk, Tadayuki, Oshima, Barbara J, Gour, J Matthew, Symonds, Jae H, Park, Christopher G, Kevil, Steven D, Trocha, Stephanie, Michaud, Naotsuka, Okayama, John W, Elrod, J Steven, Alexander, Makoto, Sasaki   +11 more
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Caveolin binds independently to claudin‐2 and occludin

Annals of the New York Academy of Sciences, 2012
Treatment of epithelial and endothelial cells with proinflammatory cytokines can stimulate tight junction protein endocytosis, with associated loss of physiologic barrier function. In some instances, the endocytic scaffolding protein, caveolin‐1, has been implicated in the cytokine‐dependent retrieval of the tight junction proteins occludin and ...
Christina M Van, Itallie, James M, Anderson   +1 more
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Occludin dephosphorylation in early development of Xenopus laevis

Journal of Cell Science, 1997
ABSTRACT Using immunobot and immunofluorescence analysis with a cross-reacting antiserum, we identified Xenopus laevis occludin as a 57-61 kDa antigen colocalized with cingulin in epithelial junctions of embryos. Occludin was completely extracted from unfertilized eggs and embryos with a solution containing 0.1% Triton X-100 and 1% NP40.
CORDENONSI, MICHELANGELO, MAZZON M., DE RIGO L., BARALDO, SIMONETTA, MEGGIO, FLAVIO, CITI, SANDRA   +5 more
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Dietary nitrite induces occludin nitration in the stomach

Free Radical Research, 2016
The clinical implications of the nitrate-nitrite-nitric oxide pathway have been extensively studied in recent years. However, the physiological impact of bioactive nitrogen oxides produced from dietary nitrate has remained largely elusive. Here, we report a hitherto unrecognized nitrite-dependent nitrating pathway that targets tight junction proteins ...
Bárbara S, Rocha, Mariana G, Correia, Rita C, Fernandes, João S, Gonçalves, João, Laranjinha   +4 more
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Expression of Occludin in Canine Testis and Epididymis

Reproduction in Domestic Animals, 2004
ContentsTight junctions (TJ) in inter‐Sertoli junctional areas and epididymal epithelia are important for the formation of blood–testis barrier (BTB) and blood–epididymal barrier (BEB). In this study, the expression of occludin, an integral member of the TJ, was verified in canine testis and epididymis.
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A phosphorylation hotspot within the occludin C‐terminal domain

Annals of the New York Academy of Sciences, 2012
Tight junctions (TJs) form paracellular barriers defining the permeability characteristics of epithelial and endothelial cell layers in our body. Tetraspanin integral membrane proteins, including occludin, tricellulin, MarvelD3, and a set of claudins, form a network of anastomosing strands bringing the membranes of neighboring cells into close contact.
Max J, Dörfel, Otmar, Huber
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Occludin expression in goldfish held in ion-poor water

Journal of Comparative Physiology B, 2008
With an emphasis on the tight junction protein occludin, the response of goldfish following abrupt exposure (0-120 h) as well as long-term acclimation (14 and 28 days) to ion-poor water (IPW) was examined. Both abrupt and long-term exposure to IPW lowered serum osmolality, [Na(+)] and [Cl(-)], and elevated serum glucose.
Helen, Chasiotis, Jennifer C, Effendi, Scott P, Kelly   +2 more
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Estrogen Enhances Esophageal Barrier Function by Potentiating Occludin Expression

Digestive Diseases and Sciences, 2015
We recently demonstrated that a female sex hormone, estrogen, suppressed esophageal epithelial injury in a reflux esophagitis model of rat, suggesting that estrogen may play an important role in controlling the progress of the gastro-esophageal reflux disease spectrum. However, the precise mechanism of the action is unclear.To investigate the potential
Junya, Honda, Katsunori, Iijima, Kiyotaka, Asanuma, Nobuyuki, Ara, Takeharu, Shiroki, Yutaka, Kondo, Waku, Hatta, Kaname, Uno, Naoki, Asano, Tomoyuki, Koike, Tooru, Shimosegawa   +10 more
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Occludin, a Constituent of Tight Junctions

2007
Occludin was the first tight junction (TJ) integral membrane protein identified. This ∼65 kDa protein specifically localizes at TJs of epithelial and endothelial cells and is incorporated into the network of TJ strands. Occludin has a predicted tetraspan membrane topology with two extracellular loops and a large COOH-terminal cytoplasmic domain.
Yan-Hua Chen, Daniel A. Goodenough, Qun Lu   +2 more
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