Results 11 to 20 of about 69,757 (296)

Penetration enhancers in ocular drug delivery [PDF]

Pharmaceutics, 2019
There are more than 100 recognized disorders of the eye. This makes the development of advanced ocular formulations an important topic in pharmaceutical science.
Abdulrazik, Afouna, Afouna, Agarwal, Albert, Bowling, Caretti, Chordiya, Chung, Denniston, Geerling, González de Llano, Grass, Hodges, Jackson, Jampilek, Kaur, Kefalov, Khutoryanskiy, , Lang, Lisch, Moiseev, , Montenegro, Morrison, Morrison, , Murphy, Nag, Pedersen, Quigley, Schachat, Schlote, Sebag, Smith, Steele, , Stefánsson, Sundaram, Tsai, Washington, Yanoff   +38 more
core   +6 more sources

Polysaccharides in Ocular Drug Delivery [PDF]

Pharmaceutics, 2019
Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies.
Natallia Dubashynskaya, Daria Poshina, Sergei Raik, Arto Urtti, Yury A. Skorik   +4 more
doaj   +4 more sources

Ocular drug delivery systems based on nanotechnology: a comprehensive review for the treatment of eye diseases [PDF]

Discover Nano
Ocular drug delivery is a significant challenge due to the intricate anatomy of the eye and the various physiological barriers. Conventional therapeutic approaches, while effective to some extent, often fall short in effectively targeting ocular diseases,
Rahul Dev Bairagi, Raiyan Rahman Reon, Md Mahbub Hasan, Sumit Sarker, Dipa Debnath, Md. Tawhidur Rahman, Sinthia Rahman, Md. Amirul Islam, Md. Abu Talha Siddique, Bishwajit Bokshi, Md. Mustafizur Rahman, Amit Kumar Acharzo   +11 more
doaj   +2 more sources

Overview of processed excipients in ocular drug delivery: Opportunities so far and bottlenecks [PDF]

Heliyon
Ocular drug delivery presents a unique set of challenges owing to the complex anatomy and physiology of the eye. Processed excipients have emerged as crucial components in overcoming these challenges and improving the efficacy and safety of ocular drug ...
Sumel Ashique, Neeraj Mishra, Sourav Mohanto, B.H. Jaswanth Gowda, Shubneesh Kumar, Amisha S. Raikar, Priya Masand, Ashish Garg, Priyanka Goswami, Ivan Kahwa   +9 more
doaj   +2 more sources

A novel approach to achieve semi-sustained drug delivery to the eye through asymmetric loading of soft contact lenses

Heliyon, 2023
Soft contact lenses are increasingly being explored as a vehicle for controlled delivery of ophthalmic drugs. However, traditional methods of drug-loading by soaking have limitations such as burst delivery and the release of drugs at the front side of ...
Malake Sarmout, Yutang Xiao, Xiao Hu, Aiym Rakhmetova, Leo H. Koole   +4 more
doaj   +1 more source

Polymeric Microspheres Designed to Carry Crystalline Drugs at Their Surface or Inside Cavities and Dimples

Pharmaceutics, 2023
Injectable polymer microparticles with the ability to carry and release pharmacologically active agents are attracting more and more interest. This study is focused on the chemical synthesis, characterization, and preliminary exploration of the utility ...
Meitong Shen, Ling Zheng, Leo H. Koole
doaj   +1 more source

Positive-charge tuned gelatin hydrogel-siSPARC injectable for siRNA anti-scarring therapy in post glaucoma filtration surgery

Scientific Reports, 2021
Small interfering RNA (siRNA) therapy is a promising epigenetic silencing strategy. However, its widespread adoption has been severely impeded by its ineffective delivery into the cellular environment.
Yong Yao Chun, Zhu Li Yap, Li Fong Seet, Hiok Hong Chan, Li Zhen Toh, Stephanie W. L. Chu, Ying Shi Lee, Tina T. Wong, Timothy T. Y. Tan   +8 more
doaj   +1 more source

A Review on Conventional and Novel Topical Ocular Drug Delivery System

Journal of Pharmacy, 2021
Ocular drug delivery is a very challenging area for ophthalmologists and drug delivery scientists due to the structural and barrier complexity of the eye.
Mohamad Faeznudin Rozi, Awis Sukarni Mohmad Sabere   +1 more
doaj   +1 more source

Ocular Drug Delivery [PDF]

The AAPS Journal, 2010
Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood-retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution ...
Ripal, Gaudana, Hari Krishna, Ananthula, Ashwin, Parenky, Ashim K, Mitra   +3 more
openaire   +2 more sources

Nanoparticles in Ocular Drug Delivery Systems. [PDF]

Pharmaceutics, 2023
Conventional ophthalmic formulations lack a prolonged drug release effect and mucoadhesive properties, decreasing their residence time in the precorneal area and, therefore, in drug penetration across ocular tissues, presenting low bioavailability with a consequent reduction in therapeutic efficacy [...]
Almeida H, Silva AC.
europepmc   +4 more sources