Results 141 to 150 of about 2,759,679 (292)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Conflicts of Interests Among Shareholders: The Case of Corporate Acquisitions [PDF]
We identify important conflicts of interests among shareholders and examine their effects on corporate decisions. When a firm is considering an action that affects other firms in its shareholders' portfolios, shareholders with heterogeneous portfolios ...
Dirk Jenter, Jarrad Harford, Kai Li
core
Dual-gRNA approach with limited off-target effect corrects C9ORF72 repeat expansion in vivo. [PDF]
Sci Rep, 2022 Piao X +5 more
europepmc +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Low-speed wind tunnel performance of high-speed counterrotation propellers at angle-of-attack [PDF]
The low-speed aerodynamic performance characteristics of two advanced counterrotation pusher-propeller configurations with cruise design Mach numbers of 0.72 were investigated in the NASA Lewis 9- by 15-Foot Low-Speed Wind Tunnel.
Gazzaniga, John A. +1 more
core +1 more source
Mechanistic mathematical modeling of abscopal effect reveals mechanisms of off-target tumor response
Frontiers in ImmunologyIntroductionLocal radiotherapy rarely triggers regression of distant, non-irradiated tumors (the “abscopal” effect), but this outcome is unpredictable because it depends on interacting processes, such as antigen release, antigen presentation, T-cell ...
Andreas G. Hadjigeorgiou +5 more
doaj +1 more source
The siRNA Off-Target Effect Is Determined by Base-Pairing Stabilities of Two Different Regions with Opposite Effects. [PDF]
Genes (Basel), 2022 Kobayashi Y, Tian S, Ui-Tei K.
europepmc +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source