Results 61 to 70 of about 2,759,679 (292)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Neuroblastoma is the most common extracranial solid tumor in early childhood. Its clinical behavior is highly variable, ranging from spontaneous regression to fatal outcome despite intensive treatment. The International Society of Pediatric Oncology Europe Neuroblastoma Group (SIOPEN) Radiology and Nuclear Medicine Specialty Committees ...
Annemieke Littooij +11 more
wiley +1 more source
Frontiers in Genetics, 2019 Therapeutic applications of CRISPR-Cas9 gene editing have spurred innovation in Cas9 enzyme engineering and single guide RNA (sgRNA) design algorithms to minimize potential off-target events. While recent work in rodents outlines favorable conditions for
Marie R. Mooney +6 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Chemotherapy‐induced peripheral neuropathy remains a major complication in pediatric cancer, with disrupted somatosensory and nociceptive processing being a key aspect. This review synthesizes empirical studies on alterations in somatosensory and nociceptive processing in children and adolescents with cancer.
Julia Schweiger +4 more
wiley +1 more source
Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity
Nature Communications, 2022 The sequence determinants governing CRISPR/Cas9 specificity are not fully understood. Here, the authors devise a high-throughput dual-target synthetic system to explore the sequence features associated with CRISPR/Cas9 off-target effect, reveal a set of ...
Rongjie Fu +13 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele +19 more
wiley +1 more source
Handling Systematic Uncertainties and Combined Source Analyses for Atmospheric Cherenkov Telescopes
, 2012 In response to an increasing availability of statistically rich observational data sets, the performance and applicability of traditional Atmospheric Cherenkov Telescope analyses in the regime of systematically dominated measurement uncertainties is ...
Conrad, Jan, Dickinson, Hugh
core +1 more source
Comparative analysis of antibody-mediated loss-of-function versus gene knock-out and knock-down
SLAS DiscoveryIn this study we compare three methods for manipulating cell function: RNA interference (RNAi), CRISPR-Cas9 gene knock-out, and antibody-mediated loss-of-function.
Marie Buck-Wiese +3 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Adolescent siblings of children with cancer are at elevated risk for psychosocial problems. Unfortunately, various barriers such as limited family time and resources, conflicting schedules, and psychosocial staffing constraints at cancer centers hinder sibling access to support.
Christina M. Amaro +10 more
wiley +1 more source
, 2016 Transmission matrices (TMs) have become a powerful and widely used tool to describe and control wave propagation in complex media. In certain scenarios the TM is partially uncontrollable, complicating its identification and use.
Daudet, Laurent +3 more
core +1 more source
Whole-genome thermodynamic analysis reduces siRNA off-target effects. [PDF]
PLoS ONE, 2013 Small interfering RNAs (siRNAs) are important tools for knocking down targeted genes, and have been widely applied to biological and biomedical research.
Xi Chen, Peng Liu, Hui-Hsien Chou
doaj +1 more source