Results 31 to 40 of about 63,056 (297)
Sleep and Oligodendrocyte Functions [PDF]
Current Sleep Medicine Reports, 2015 Transcriptomic studies have revealed that the brains of sleeping and awake animals differ significantly at the molecular level, with hundreds of brain transcripts changing their expression across behavioral states. However, it was unclear how sleep affects specific cells types, such as oligodendrocytes, which make myelin in the healthy brain and in ...
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Embracing oligodendrocyte diversity in the context of perinatal injury
Neural Regeneration Research, 2017 Emerging evidence is fueling a new appreciation of oligodendrocyte diversity that is overturning the traditional view that oligodendrocytes are a homogenous cell population.
Jessie Newville +2 more
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The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2022 Background Our case explored the spectrum of autoimmune and infectious neurological complications of Coronavirus Disease 2019. In addition, we also reviewed and discussed clinical features, neuroimaging, CSF findings, and outcomes in patients with COVID ...
Mark A. Colantonio +7 more
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Glial Purinergic Signaling in Neurodegeneration
Frontiers in Neurology, 2021 Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-
Marie J. Pietrowski +9 more
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Neural Regeneration ResearchDifferentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to remyelination. Failure of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve damage.
Jian Yang +9 more
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FEBS Open Bio, EarlyView.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
wiley +1 more source
Mutation of pescadillo disrupts oligodendrocyte formation in zebrafish.
PLoS ONE, 2012 BackgroundIn vertebrates, the myelin sheath is essential for efficient propagation of action potentials along the axon shaft. Oligodendrocytes are the cells of the central nervous system that create myelin sheaths.
Timothy Simmons, Bruce Appel
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Evolutionary Origins of the Oligodendrocyte Cell Type and Adaptive Myelination
Frontiers in Neuroscience, 2021 Oligodendrocytes are multifunctional central nervous system (CNS) glia that are essential for neural function in gnathostomes. The evolutionary origins and specializations of the oligodendrocyte cell type are among the many remaining mysteries in glial ...
Jacob H. Hines
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CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu +12 more
wiley +1 more source
Oligodendrocyte Development and Plasticity [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Oligodendrocyte precursor cells (OPCs) originate in the ventricular zones (VZs) of the brain and spinal cord and migrate throughout the developing central nervous system (CNS) before differentiating into myelinating oligodendrocytes (OLs). It is not known whether OPCs or OLs from different parts of the VZ are functionally distinct.
William D. Richardson, Dwight E. Bergles
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