Results 31 to 40 of about 92,957 (356)
Nature Communications, 2019 Oligodendrocyte precursor cells (OPCs) are abundant in the adult central nervous system, and have the capacity to regenerate oligodendrocytes and myelin. However, in inflammatory diseases such as multiple sclerosis (MS) remyelination is often incomplete.
L. Kirby +14 more
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Demyelination and oligodendrocytes
Rinsho Shinkeigaku, 2011 Although neurological sequelae are attributable to poor regeneration of the central nervous system, oligodendrocytes demonstrate robust regenerative response even in adults. Accumulating evidence indicates that the glial cells identified by surface expression of the proteoglycan NG2 are the cellular source of newly-developed oligodendrocytes following ...
Aki Itoh +4 more
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Oligodendrocytes in intracerebral hemorrhage [PDF]
CNS Neuroscience & Therapeutics, 2019 AbstractIntracerebral hemorrhage (ICH) is a cerebrovascular disorder with high mortality and disability rates. Although a lot of effort has been put in ICH, there is still no effective treatment for this devastating disease. Recent studies suggest that oligodendrocytes play an important role in brain repair after ICH and thus may be targeted for the ...
Minkyung Kang, Yao Yao
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In vivo conversion of astrocytes into oligodendrocyte lineage cells with transcription factor Sox10; Promise for myelin repair in multiple sclerosis. [PDF]
PLoS ONE, 2018 Recent studies demonstrate that astroglial cells can be directly converted into functional neurons or oligodendrocytes. Here, we report that a single transcription factor Sox10 could reprogram astrocytes into oligodendrocyte-like cells, in vivo.
Akram Mokhtarzadeh Khanghahi +4 more
doaj +1 more source
pH Microdomains in Oligodendrocytes [PDF]
Journal of Biological Chemistry, 2004 Oligodendrocytes (OLs) are cells that produce myelin in the central nervous system. Here we use ratiometric pH indicator dye to analyze intracellular pH in OLs in culture. The results reveal alkaline microdomains, which predominate in the perikaryon and proximal dendrites, and acidic microdomains, which predominate in distal dendrites.
Hyun-ah Ro, John H. Carson
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Stalled oligodendrocyte differentiation in IDH-mutant gliomas
Genome Medicine, 2023 Background Roughly 50% of adult gliomas harbor isocitrate dehydrogenase (IDH) mutations. According to the 2021 WHO classification guideline, these gliomas are diagnosed as astrocytomas, harboring no 1p19q co-deletion, or oligodendrogliomas, harboring ...
Yanfei Wei +17 more
doaj +1 more source
bioRxiv, 2019 Recent reports have revealed that oligodendrocyte precursor cells (OPCs) are heterogeneous. It remains unclear whether such heterogeneity reflects different subtypes of cells with distinct functions or instead reflects transiently acquired states of ...
Tobias Hoche +7 more
semanticscholar +1 more source
Hyper-viscoelastic 3D response of axons subjected to repeated tensile loads in brain white matter [PDF]
arXiv, 2022 A novel finite element method (FEM) is developed to study mechanical response of axons embedded in extra cellular matrix (ECM) when subjected to harmonic uniaxial stretch under purely non-affine kinematic boundary conditions. The proposed modeling approach combines hyper-elastic (such as Ogden model) and time/frequency domain viscoelastic constitutive ...
arxiv
Oligodendrocyte generation dynamics in multiple sclerosis
Nature, 2018 Oligodendrocytes wrap nerve fibres in the central nervous system with layers of specialized cell membrane to form myelin sheaths1. Myelin is destroyed by the immune system in multiple sclerosis, but myelin is thought to regenerate and neurological ...
Maggie S. Y. Yeung +7 more
semanticscholar +1 more source
GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration [PDF]
Cell Reports, 2021 Oligodendrocyte precursor cells (OPCs) are essential for developmental myelination and oligodendrocyte regeneration after CNS injury. These progenitors express calcium-permeable AMPA receptors (AMPARs) and form direct synapses with neurons throughout the CNS, but the roles of this signaling are unclear.
Rabia R. Khawaja +8 more
openaire +4 more sources