Premyelinating Oligodendrocytes: Mechanisms Underlying Cell Survival and Integration
Frontiers in Cell and Developmental Biology, 2021 In the central nervous system, oligodendrocytes produce myelin sheaths that enwrap neuronal axons to provide trophic support and increase conduction velocity.
Ethan G. Hughes, Michael E. Stockton
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Nature Reviews Neuroscience, 2006 Oligodendrocyte precursors first arise in a restricted ventral part of the embryonic spinal cord and migrate laterally and dorsally from there. Later, secondary sources develop in the dorsal cord. Normally, the ventrally-derived precursors compete with and suppress their dorsal counterparts.
William D, Richardson +2 more
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SHP-2 promotes the maturation of oligodendrocyte precursor cells through Akt and ERK1/2 signaling in vitro. [PDF]
PLoS ONE, 2011 BACKGROUND: Oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes (OLs), which are responsible for myelination. Myelin is essential for saltatory nerve conduction in the vertebrate nervous system. However, the molecular mechanisms of
Xiujie Liu +8 more
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Nogo-A aggravates oxidative damage in oligodendrocytes
Neural Regeneration Research, 2021 Nogo-A is considered one of the most important inhibitors of myelin-associated axonal regeneration in the central nervous system. It is mainly expressed by oligodendrocytes.
Yang-Yang Wang +3 more
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GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration [PDF]
Cell Reports, 2021 Oligodendrocyte precursor cells (OPCs) are essential for developmental myelination and oligodendrocyte regeneration after CNS injury. These progenitors express calcium-permeable AMPA receptors (AMPARs) and form direct synapses with neurons throughout the CNS, but the roles of this signaling are unclear.
Rabia R. Khawaja +8 more
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Neuron-Oligodendrocyte Interactions in the Structure and Integrity of Axons
Frontiers in Cell and Developmental Biology, 2021 The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction. Oligodendrocytes and axons have a reciprocal signaling relationship in which oligodendrocytes receive cues from axons that direct their myelination, and ...
Greg J. Duncan +4 more
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Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells. [PDF]
PLoS ONE, 2017 Oligodendrocytes myelinate axons and form myelin sheaths in the central nervous system. The development of therapies for demyelinating diseases, including multiple sclerosis and leukodystrophies, is a challenge because the pathogenic mechanisms of ...
Tomoko Yamashita +12 more
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REDOX Balance in Oligodendrocytes Is Important for Zebrafish Visual System Regeneration
Antioxidants, 2023 Zebrafish (Danio rerio) present continuous growth and regenerate many parts of their body after an injury. Fish oligodendrocytes, microglia and astrocytes support the formation of new connections producing effective regeneration of the central nervous ...
Cristina Pérez-Montes +5 more
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The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina
Cell Reports, 2023 Summary: Oligodendrocytes are specialized cells that insulate and support axons with their myelin membrane, allowing proper brain function. Here, we identify lamin A/C (LMNA/C) as essential for transcriptional and functional stability of myelinating ...
Mathilde Pruvost +17 more
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Cyclooxygenase-2 expression in oligodendrocytes increases sensitivity to excitotoxic death
Journal of Neuroinflammation, 2010 Background We previously found that cyclooxygenase 2 (COX-2) was expressed in dying oligodendrocytes at the onset of demyelination in the Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) model of multiple sclerosis (MS ...
Rojas Monica A +6 more
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