Results 11 to 20 of about 113,519 (282)
Gliopathy of Demyelinating And Non-Demyelinating Strains Of Mouse Hepatitis Virus.
Frontiers in Cellular Neuroscience, 2015 Demyelination in the central nervous system induced by neurovirulent strains of Mouse Hepatitis Virus (MHV) is mediated by the viral spike glycoprotein, but it is not clear whether the mechanism of this disease pathology involves direct viral infection ...
Lawrence Charles Kenyon +7 more
doaj +1 more source
Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]
, 2016 Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai +3 more
core +2 more sources
Oligodendrocyte-specific ATF4 inactivation does not influence the development of EAE
Journal of Neuroinflammation, 2019 Background Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory demyelinating and neurodegenerative diseases of the CNS.
Yuan Yue +4 more
doaj +1 more source
Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. [PDF]
, 2013 Oligodendrocytes associate with axons to establish myelin and provide metabolic support to neurons. In the spinal cord of amyotrophic lateral sclerosis (ALS) mice, oligodendrocytes downregulate transporters that transfer glycolytic substrates to neurons ...
Bergles, Dwight E +7 more
core +2 more sources
Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. [PDF]
, 2013 NG2 (nerve/glial antigen2)-expressing cells represent the largest population of postnatal progenitors in the central nervous system and have been classified as oligodendroglial progenitor cells, but the fate and function of these cells remain ...
Chung, S-H +4 more
core +2 more sources
PLoS ONE, 2017 Within the microenvironment of multiple sclerosis lesions, oligodendrocytes are subject to metabolic stress reflecting effects of focal ischemia and inflammation.
Vijayaraghava T S Rao +9 more
doaj +1 more source
Disease-Associated Oligodendrocyte: New Player in Alzheimer's Disease and CNS Pathologies
Journal of Integrative Neuroscience, 2023 Considerable evidence has shown that the breakdown of myelin has been linked to Alzheimer’s disease (AD). Considering the vulnerability of oligodendrocytes to Alzheimer’s disease, the myelin sheath breakdown and degeneration are easily induced ...
Peng Chen, ZhiLei Guo, Benhong Zhou
doaj +1 more source
The immunomodulatory oligodendrocyte [PDF]
Brain Research, 2016 Oligodendrocytes, the myelinating glial cells of the central nervous system (CNS), are due to their high specialization and metabolic needs highly vulnerable to various insults. This led to a general view that oligodendrocytes are defenseless victims during brain damage such as occurs in acute and chronic CNS inflammation.
Zeis, Thomas +2 more
openaire +3 more sources
TASK-1 channels in oligodendrocytes: A role in ischemia mediated disruption
Neurobiology of Disease, 2013 Oligodendrocytes are the myelinating cells of the CNS and, like neurons, are highly sensitive to ischemic damage. However, the mechanisms underlying cytotoxicity in oligodendrocytes during hypoxic/ischemic episodes are not fully understood. TASK-1 is a K+
Virginia Hawkins, Arthur Butt
doaj +1 more source
Fluids and Barriers of the CNS, 2023 Background Oligodendrocyte lineage cells interact with the vasculature in the gray matter. Physical and functional interactions between blood vessels and oligodendrocyte precursor cells play an essential role in both the developing and adult brain ...
Justine S. C. Palhol +5 more
doaj +1 more source