Hydrolysis of Oligodeoxyribonucleotides on the Microarray Surface and in Solution by Catalytic Anti-DNA Antibodies in Systemic Lupus Erythematosus [PDF]
Current Issues in Molecular Biology, 2023 Anti-DNA antibodies are known to be classical serological hallmarks of systemic lupus erythematosus (SLE). In addition to high-affinity antibodies, the autoantibody pool also contains natural catalytic anti-DNA antibodies that recognize and hydrolyze DNA.
Tatiana S. Novikova +6 more
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Efficiency of genome editing using modified single-stranded oligodeoxyribonucleotides in human cells [PDF]
Scientific ReportsSingle-stranded oligodeoxyribonucleotide (ssODN) gene editing has emerged as a promising therapeutic strategy. However, further improvements in efficiency are desired for practical application.
Seryoung Kim +3 more
doaj +2 more sources
Application of the weighted histogram method for calculating the thermodynamic parameters of the formation of oligodeoxyribonucleotide duplexes [PDF]
Вавиловский журнал генетики и селекции, 2023 To date, many derivatives and analogs of nucleic acids (NAs) have been developed. Some of them have found uses in scientific research and biomedical applications. Their effective use is based on the data about their properties. Some of the most important
I. I. Yushin +3 more
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Experimental optimization of probe length to increase the sequence specificity of high-density oligonucleotide microarrays [PDF]
BMC Genomics, 2007 Background High-density oligonucleotide arrays are widely used for analysis of genome-wide expression and genetic variation. Affymetrix GeneChips – common high-density oligonucleotide arrays – contain perfect match (PM) and mismatch (MM) probes generated
Kashiwagi Akiko +4 more
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Frontiers and Approaches to Chemical Synthesis of Oligodeoxyribonucleotides
Molecules, 2013 The advantages and disadvantages of existing approaches to the synthesis of oligodeoxyribonucleotides (ODN) are discussed focusing on large-scale methods. The liquid phase and solid supported synthesis and the synthesis on soluble polymers are discussed.
Tatyana Abramova
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Molecules, 2023 Raman nanoparticle probes are a potent class of optical labels for the interrogation of pathological and physiological processes in cells, bioassays, and tissues.
Monica-Cornelia Sardaru +4 more
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Glutathione Mediates Control of Dual Differential Bio‐orthogonal Labelling of Biomolecules
Angewandte Chemie, Volume 135, Issue 50, December 11, 2023., 2023 The chemical modification at precise sites within biomolecules is essential to assist in understanding their function. The incorporation of bio‐orthogonal reactive groups provides a strategy for selective tagging, however cross‐reactivity is problematic when dual modification is required.
Frederik Peschke +4 more
wiley +2 more sources
Biomolecules, 2020 Human neutrophils are the first line of defense against bacterial and viral infections. They eliminate pathogens through phagocytosis, which activate the 5-lipoxygenase (5-LOX) pathway resulting in synthesis of leukotrienes.
Ekaterina A. Golenkina +6 more
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Synthesis and radioiodination of a stannyl oligodeoxyribonucleotide [PDF]
Nucleic Acids Research, 1997 Synthesis and radioiodination of a stannyl oligodeoxyribonucleotide were undertaken to evaluate a gamma ray emitting ODN ligand for thrombus imaging in vivo . Synthesis of the ODN was based on modified automatedbeta-cyanoethyl phosphoramidite chemistry with an organotin nucleoside (dU*) coupled to a thrombin binding aptamer sequence to give d(U ...
Hayes Dougan +3 more
openaire +2 more sources
Facile enzymatic synthesis of base J-containing oligodeoxyribonucleotides and an analysis of the impact of base J on DNA replication in cells. [PDF]
PLoS ONE, 2014 We reported here the use of T4 bacteriophage β-glucosyltransferase (T4 β-GT) for the facile synthesis of base J-containing oligodeoxyribonucleotides (ODNs). We found that the enzyme could catalyze the glucosylation of 5-hydroxymethyl-2-deoxyuridine (5hmU)
Debin Ji, Yinsheng Wang
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