Results 21 to 30 of about 15,454 (234)
Design of an N^7-Glycosylated Purine Nucleoside for Recognition of GC Base Pairs by Triple Helix Formation [PDF]
, 1995 Pyrimidine oligodeoxyribonucleotides bind in the major groove of DNA parallel to the purine Watson-Crick strand by formation of specific hydrogen bonds between thymine and adenine (T•AT triplet) and protonated cytosine and guanine (C+GC triplet) on the ...
Brunar, Helmut +3 more
core +2 more sources
Clinical and Translational Medicine, Volume 13, Issue 1, January 2023., 2023 Non‐union and delayed fracture healing are major problems for patient treatment; biomarkers such as miRNA can help predicting complications. A systematic review approach identified key miRNA involved in non‐union or delayed fracture healing. Identification of the 6 most investigated miRNA in fracture healing with role in key pathways.
Franziska Lioba Breulmann +6 more
wiley +1 more source
Reduction of Metal Ions by Boranephosphonate DNA [PDF]
, 2012 Oligodeoxyribonucleotides bearing boranephosphonate linkages (bpDNA) were shown to reduce a number of metal ions and form nanoparticles through a novel reaction pathway that leads to phosphate diesters or phosphate triesters in water or alcohols ...
Caruthers, Marvin H. +4 more
core +3 more sources
The Chemical Record, Volume 22, Issue 11, November 2022., 2022 Mechanisms of chemical cleavage and isomerization of RNA phosphodiester bonds discussed as a contribution to conception of a plausible unified picture of bio‐catalytic RNA cleavage Abstract The cleavage of RNA phosphodiester bonds by RNase A and hammerhead ribozyme at neutral pH fundamentally differs from the spontaneous reactions of these bonds under ...
Harri Lönnberg
wiley +1 more source
Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]
, 1991 We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Kaluzab, Brigitte +4 more
core +1 more source
Core‐Shell DNA‐Cholesterol Nanoparticles Exert Lysosomolytic Activity in African Trypanosomes**
ChemBioChem, Volume 23, Issue 20, October 19, 2022., 2022 The bioengineering of synthetic nanoparticles with therapeutic potential for the treatment of African sleeping sickness is reported. The molecules are DNA‐cholesterol amphiphiles, which self‐assemble into micelle‐type nanoparticles with an exterior DNA shell and a lipid core. The particles are constructed to attack two parasite‐specific targets thereby
Robert Knieß +4 more
wiley +1 more source
BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair [PDF]
, 2011 Repair of dsDNA breaks requires processing to produce 3′-terminated ssDNA. We biochemically reconstituted DNA end resection using purified human proteins: Bloom helicase (BLM); DNA2 helicase/nuclease; Exonuclease 1 (EXO1); the complex comprising MRE11 ...
Campbell, Judith L. +7 more
core +3 more sources
Вавиловский журнал генетики и селекции, 2022 The GRIN1, ASCL3, and NOS1 genes are associated with various phenotypes of neuropsychiatric disorders. For instance, these genes contribute to the development of schizophrenia, Alzheimer’s and Parkinson’s diseases, and epilepsy.
E. B. Sharypova +4 more
doaj +1 more source
Effects of an abasic site on triple helix formation characterized by affinity cleaving [PDF]
, 1991 The stability of triple helical complexes of pyrimidine oligodeoxyribonucleotides containing one abasic 1,2- dideoxy-D-ribose (ø) residue was examined by affinity cleaving.
Dervan, Peter B., Horne, David A.
core +2 more sources
Convenient synthesis of arabinonucleoside containing oligodeoxyribonucleotides [PDF]
Nucleic Acids Symposium Series, 2000 C2 substituted arabinofuranosyluracil derivatives were synthesized and its incorporations into DNA were easily carried out by using post-synthetic modification.
Kiyohiro Nakajima +3 more
openaire +3 more sources