Results 31 to 40 of about 11,991 (190)

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

Advanced Science, EarlyView.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li, Yuge Chen, Dongdong Tang, Yuying Sheng, Xu Han, Hao Geng, Na Zhang, Zongliu Duan, Guanxiong Wang, Yang Gao, Rui Guo, Rong Hua, Zhiming Ding, Chuan Xu, Qunshan Shen, Zhen Yu, Bing Song, Mingrong Lv, Yuping Xu, Huan Wu, Ji Wu, Yunxia Cao, Xiaojin He   +22 more
wiley   +1 more source

Cas9‐ and Cas12a‐mediated excision and replacement of the celiac disease‐related α‐gliadin immunogenic complex in hexaploid wheat

Plant Biotechnology Journal, Volume 23, Issue 9, Page 3798-3813, September 2025.
Summary Celiac disease (CD) is a chronic enteropathy affecting approximately 1% of the global population. Wheat α‐gliadins are a major contributor to the autoimmune response, as they contain one of the most immunogenic peptides, the 33‐mer, along with numerous variants.
Miriam Marín‐Sanz, Susana Sánchez‐León, María H. Guzmán‐López, Colby G. Starker, Daniel F. Voytas, Francisco Barro   +5 more
wiley   +1 more source

Inhibition of MicroRNA-124 Reduces Cardiomyocyte Apoptosis Following Myocardial Infarction via Targeting STAT3

Cellular Physiology and Biochemistry, 2018
Background/Aims: MicroRNAs play an important role in regulating myocardial infarction (MI)-induced cardiac injury. MicroRNA-124 (miR-124) plays a vital role in regulating cellular proliferation, differentiation and apoptosis.
Fang He, Huibin Liu, Jing Guo, Di Yang, Yang Yu, Jie Yu, Xiuqing Yan, Juan Hu, Zhimin Du   +8 more
doaj   +1 more source

The Comprehensive Roadmap Toward Malaria Elimination Using Graphene and its Promising 2D Analogs

Advanced NanoBiomed Research, Volume 5, Issue 8, August 2025.
Material based on a diversity of graphene with chemical properties of strong strength, high mobility, high transparency, good heat conductivity, biocompatibility, and chemical stability, advanced devices demonstrating antimalarial characteristics can be used for malaria treatment at different stages of malaria development from the injection of ...
Fangzhou He, George Junior, Rajashree Konar, Yuanding Huang, Ke Zhang, Lijing Ke, Meng Niu, Boon Tong Goh, Amine El Moutaouakil, Gilbert Daniel Nessim, Mohamed Belmoubarik, Weng Kung Peng   +11 more
wiley   +1 more source

An engineered redox‐switchable streptavidin mutein enables the high‐affinity capture and efficient elution of biotinylated ligands

Protein Science, Volume 34, Issue 8, August 2025.
Abstract Although the high affinity and specificity of the interaction between streptavidin and biotin are widely utilized to isolate biotinylated ligands, their elution over practical timescales requires the use of strongly denaturing conditions that are incompatible with many target biomolecules.
Jesse M. Marangoni, Adriana Zutic, Amrita Dhindsa, Emmanuella Uche‐Orji, Sui‐Lam Wong, Kenneth K. S. Ng   +5 more
wiley   +1 more source

Interfacing B‐DNA and DNA Mimic Foldamers

Angewandte Chemie International Edition, Volume 64, Issue 31, July 28, 2025.
Helical aromatic oligoamide DNA mimic foldamers that reproduce the shape and charge distribution of duplex B‐DNA have been interfaced with DNA duplexes by means of a new linker that serves both as a DNA hairpin and as an aromatic oligoamide unit. In the resulting chimeric molecules, the linker does not perturb the DNA duplex structure and converts the ...
Manuel Loos, Felix Xu, Pradeep K. Mandal, Tulika Chakrabortty, Céline Douat, David B. Konrad, Melis Cabbar, Johannes Singer, Valentina Corvaglia, Thomas Carell, Ivan Huc   +10 more
wiley   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, Volume 12, Issue 28, July 24, 2025.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Nanomaterials for acute myeloid leukemia therapy: Current progress and future perspectives

Interdisciplinary Medicine, Volume 3, Issue 3, May 2025.
Infographics of this review introducing the current treatment strategies, types of nanomaterials, and their advantages in AML treatment (Created with BioRender.com, a license purchased, accessed on March 26, 2024). Abstract Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy characterized by poor prognosis, high relapse rates ...
Jiarui Zhao, Jiaqi Cui, Lixuan Wang, Xinyi Shi, Jiayan Ding, Muhammad Farhan Sohail, Irshad Hussain, Qihui Liu, Fangfang Chen   +8 more
wiley   +1 more source

Exploring the importance of predicted camel NRAP exon 4 for environmental adaptation using a mouse model

Animal Genetics, Volume 56, Issue 1, February 2025.
Abstract Camels possess exceptional adaptability, allowing them to withstand extreme temperatures in desert environments. They conserve water by reducing their metabolic rate and regulating body temperature. The heart of the camel plays a crucial role in this adaptation, with specific genes expressed in cardiac tissue that are essential for mammalian ...
Sung‐Yeon Lee, Bo‐Young Lee, Byeonghwi Lim, Rasel Uzzaman, Goo Jang, Kwan‐Suk Kim   +5 more
wiley   +1 more source

Analysis of efficiency of purification of HEX-oligonucleotides obtained by modified deblocking

Тонкие химические технологии, 2012
A new way of deblocking of synthetic hexachlorofluorescein-oligodeoxyribonucleotides (HEX-ODN) prevents the modification of the label and the accumulation of difficult to separated by-product.
A. G. Mosina, A. N. Chuvilin, I. P. Smirnov, V. F. Travkin, G. E. Pozmogova   +4 more
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