Results 41 to 50 of about 11,991 (190)

Antiviral activity of modified oligonucleotides in human lymphoid cells infected with a strain of HIV‐1

Юг России: экология, развитие
Aim. To investigate the cell entry and antiretroviral properties of modified oligodeoxyribonucleotides targeting highly conserved regions of the HIV‐1 genome: the study was conducted using modified oligonucleotides containing phosphorothioate ...
L. G. Gotfrid, A. S. Pavlova, M. S. Kupryushkin, I. A. Pyshnaya, N. M. Gashnikova   +4 more
doaj   +1 more source

Synthesis of oligodeoxyribonucleotide N3′→P5′ phosphoramidates

Nucleic Acids Research, 1995
An efficient synthesis of the novel nucleic acid analogs oligodeoxyribonucleotide N3'-->P5' phosphoramidates, where the 3'-oxygen is substituted by a 3'-nitrogen, is described. Synthesis of the title compounds was accomplished by the following synthetic steps. First, 5'-O-DMT base-protected-3'-amino-2',3'-dideoxynucleosides were prepared.
J K, Chen, R G, Schultz, D H, Lloyd, S M, Gryaznov   +3 more
openaire   +3 more sources

Spheroid culture to select theoretical therapeutic drugs in intravascular large B‐cell lymphoma

Cancer Science, Volume 116, Issue 1, Page 214-225, January 2025.
Abstract Intravascular large B‐cell lymphoma (IVLBCL) is a rare type of extranodal large B‐cell lymphoma that is characterized by the proliferation of lymphoma cells in the lumina of small vessels. Recent progress uncovering the genetic characteristics associated with MYD88/CD79B mutations has stimulated interest in the use of drugs targeting B‐cell ...
Mika Takai, Kazuyuki Shimada, Katsuya Furukawa, Yusuke Yamaga, Soichi Yoshiyama, Yusuke Kagaya, Takashi Suzuki, Kazuhiko Hayashi, Satoko Shimada, Kennosuke Karube, Hitoshi Kiyoi   +10 more
wiley   +1 more source

Nanostructural Modulation of G‐Quadruplex DNA in Neurodegeneration: Orotate Interaction Revealed Through Experimental and Computational Approaches

Journal of Neurochemistry, Volume 169, Issue 1, January 2025.
Aim of this study is to investigate drugs that modulate GGGGCC repeat aggregation, a key feature in neurodegenerative diseases such as ALS and FTD. The research emphasizes the role of the C9orf72 gene, which is implicated in these disorders, and focuses on G‐quadruplex (G4) DNA structures formed by these repeats.
Andrea Patrizia Falanga, Ilaria Piccialli, Francesca Greco, Stefano D'Errico, Maria Grazia Nolli, Nicola Borbone, Giorgia Oliviero, Giovanni N. Roviello   +7 more
wiley   +1 more source

Oligonucleotide‐Based Photoaffinity Probes: Chemical Tools and Applications for Protein Labeling

ChemBioChem, Volume 25, Issue 19, October 1, 2024.
Photoactivatable oligonucleotides in combination with recent developments in mass spectrometry are powerful tools for studying nucleic acid‐protein interactions involved in numerous biological processes. In this review, we provide a comprehensive overview of the different strategies for incorporating the most used photoreactive reagents into ...
Carole Saintomé, Océane Monfret, Gilles Doisneau, Dominique Guianvarc'h   +3 more
wiley   +1 more source

Chemical Syntheses of Oligodeoxyribonucleotides Containing Spore Photoproduct [PDF]

The Journal of Organic Chemistry, 2013
5-(α-Thyminyl)-5,6-dihydrothymine, also called spore photoproduct or SP, is commonly found in the genomic DNA of UV-irradiated bacterial endospores. Despite the fact that SP was discovered nearly 50 years ago, its biochemical impact is still largely unclear due to the difficulty of preparing SP-containing oligonucleotide in high purity. Here, we report
Yajun, Jian, Lei, Li
openaire   +2 more sources

CRKL but not CRKII contributes to hemin‐induced erythroid differentiation of CML

Journal of Cellular and Molecular Medicine, Volume 28, Issue 9, May 2024.
Abstract Destruction of erythropoiesis process leads to various diseases, including thrombocytopenia, anaemia, and leukaemia. miR‐429‐CT10 regulation of kinase‐like (CRKL) axis involved in development, progression and metastasis of cancers. However, the exact role of miR‐429‐CRKL axis in leukaemic cell differentiation are still unknown.
Chunmei Guo, Xinxin Lv, Qiuling Zhang, Lina Yi, Yingying Ren, Zhaopeng Li, Jinsong Yan, Shanliang Zheng, Ming‐Zhong Sun, Shuqing Liu   +9 more
wiley   +1 more source

Reactive oxygen species are signaling molecules that modulate plant reproduction

Plant, Cell &Environment, Volume 47, Issue 5, Page 1592-1605, May 2024.
Abstract Reactive oxygen species (ROS) can serve as signaling molecules that are essential for plant growth and development but abiotic stress can lead to ROS increases to supraoptimal levels resulting in cellular damage. To ensure efficient ROS signaling, cells have machinery to locally synthesize ROS to initiate cellular responses and to scavenge ROS
Mohammad Foteh Ali, Gloria K. Muday
wiley   +1 more source

Study on Growth Inhibition of Implanted Tumor in Nude Mice by Antisense Oligodeoxynucleotide Targeting Telomerase RNA

Chinese Journal of Lung Cancer, 2008
Background and Objective Many studies have proven that telomerase plays an important role during the occurrence and development of lung cancer, which has been an important target in gene therapy.
Hongtao YU, Hongjun WANG, Qiong CHEN
doaj  

Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy

Advanced Science, Volume 11, Issue 1, January 5, 2024.
Deregulated Inflammation is one of the most common diseases in human health, and its management remains a significant challenge. Notably, stimulus‐responsive hydrogels have great potential to break through the predicament faced by severe inflammations treatment.
Haoyu Yu, Rongyao Gao, Yuxin Liu, Limin Fu, Jing Zhou, Luoyuan Li   +5 more
wiley   +1 more source