Results 51 to 60 of about 15,454 (234)

Nucleic acid - protein fingerprints. Novel protein classification based on nucleic acid - protein recognition [PDF]

, 2012
Protein chemistry uses protein description and classification based on molecular mass and isoelectric point as general features. Enzymes are also compared by enzymatic reaction constants, namely Km and kcat values. Proteins are also studied by binding to
Alexander Krylov, Renad Zhdanov
core   +1 more source

The Comprehensive Roadmap Toward Malaria Elimination Using Graphene and its Promising 2D Analogs

Advanced NanoBiomed Research, EarlyView.
Material based on a diversity of graphene with chemical properties of strong strength, high mobility, high transparency, good heat conductivity, biocompatibility, and chemical stability, advanced devices demonstrating antimalarial characteristics can be used for malaria treatment at different stages of malaria development from the injection of ...
Fangzhou He, George Junior, Rajashree Konar, Yuanding Huang, Ke Zhang, Lijing Ke, Meng Niu, Boon Tong Goh, Amine El Moutaouakil, Gilbert Daniel Nessim, Mohamed Belmoubarik, Weng Kung Peng   +11 more
wiley   +1 more source

Iterative approach to computational enzyme design [PDF]

, 2012
A general approach for the computational design of enzymes to catalyze arbitrary reactions is a goal at the forefront of the field of protein design. Recently, computationally designed enzymes have been produced for three chemical reactions through the ...
Blomberg, Rebecca, Chica, Roberto A., Hilvert, Donald, Houk, Kendall N., Kiss, Gert, Lee, Toni M., Mayo, Stephen L., Privett, Heidi K., Thomas, Leonard M.   +8 more
core   +2 more sources

Interfacing B‐DNA and DNA Mimic Foldamers

Angewandte Chemie International Edition, Accepted Article.
A linker unit was designed and synthesized that can serve both as a hairpin turn in a DNA duplex and anchor point for an aromatic helical foldamer mimicking the shape and surface properties of B‐DNA. Methods were developed to synthesize natural/non‐natural chimeric molecules combining foldamer and DNA segments. The ability of the linker to position the
Manuel Loos, Felix Xu, Pradeep K. Mandal, Tulika Chakrabortty, Céline Douat, David B. Konrad, Melis Cabbar, Johannes Singer, Valentina Corvaglia, Thomas Carell, Ivan Huc   +10 more
wiley   +1 more source

A microfluidic oligonucleotide synthesizer [PDF]

, 2010
De novo gene and genome synthesis enables the design of any sequence without the requirement of a pre-existing template as in traditional genetic engineering methods.
Lee, Cheng-Chung, Quake, Stephen R., Snyder, Thomas M.   +2 more
core   +4 more sources

Improvements in the phosphoramidite procedure for the synthesis of oligodeoxyribonucleotides

Nucleic Acids Research, 1983
The paper describes an improved method for the synthesis of oligodeoxyribonucleotides using phosphoramidite chemistry. Our procedure relies on novel phosphoramidite intermediates, the deoxyribonucleoside-3'-morpholine-methoxyphosphins. These compounds are extremely stable and can be purified readily.
Emst-L Winnacker, Thomas Dorper
openaire   +4 more sources

Nanomaterials for acute myeloid leukemia therapy: Current progress and future perspectives

Interdisciplinary Medicine, Volume 3, Issue 3, May 2025.
Infographics of this review introducing the current treatment strategies, types of nanomaterials, and their advantages in AML treatment (Created with BioRender.com, a license purchased, accessed on March 26, 2024). Abstract Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy characterized by poor prognosis, high relapse rates ...
Jiarui Zhao, Jiaqi Cui, Lixuan Wang, Xinyi Shi, Jiayan Ding, Muhammad Farhan Sohail, Irshad Hussain, Qihui Liu, Fangfang Chen   +8 more
wiley   +1 more source

Inhibition of MicroRNA-124 Reduces Cardiomyocyte Apoptosis Following Myocardial Infarction via Targeting STAT3

Cellular Physiology and Biochemistry, 2018
Background/Aims: MicroRNAs play an important role in regulating myocardial infarction (MI)-induced cardiac injury. MicroRNA-124 (miR-124) plays a vital role in regulating cellular proliferation, differentiation and apoptosis.
Fang He, Huibin Liu, Jing Guo, Di Yang, Yang Yu, Jie Yu, Xiuqing Yan, Juan Hu, Zhimin Du   +8 more
doaj   +1 more source

Synthesis of oligodeoxyribonucleotides containing a tricyclic thio analogue of O6-methylguanine and their recognition by MGMT and Atl1 [PDF]

, 2020
Promutagenic O6-alkylguanine adducts in DNA are repaired in humans by O6-methylguanine-DNA-methyltransferase (MGMT) in an irreversible reaction. Here we describe the synthesis of a phosphoramidite that allows the preparation of oligodeoxyribonucleotides (
Abdu, K., Aiertza, M.K., Craggs, T.D., Margison, G.P., Povey, A.C., Senthong, P., Wilkinson, O.J., Williams, D.M.   +7 more
core   +1 more source

Exploring the importance of predicted camel NRAP exon 4 for environmental adaptation using a mouse model

Animal Genetics, Volume 56, Issue 1, February 2025.
Abstract Camels possess exceptional adaptability, allowing them to withstand extreme temperatures in desert environments. They conserve water by reducing their metabolic rate and regulating body temperature. The heart of the camel plays a crucial role in this adaptation, with specific genes expressed in cardiac tissue that are essential for mammalian ...
Sung‐Yeon Lee, Bo‐Young Lee, Byeonghwi Lim, Rasel Uzzaman, Goo Jang, Kwan‐Suk Kim   +5 more
wiley   +1 more source